Vdr<sup>em1Thka</sup> (vitamin D receptor; CRISPR/Cas9 induced mutant 1, Thka) - Rat Genome Database

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Gene: Vdrem1Thka (vitamin D receptor; CRISPR/Cas9 induced mutant 1, Thka) Rattus norvegicus
Symbol: Vdrem1Thka
Name: vitamin D receptor; CRISPR/Cas9 induced mutant 1, Thka
RGD ID: 124713547
Description: This mutation was created by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to disrupt the array near the arginine codon (CGC) at position 270 of the Vdr gene. This resulted in changing arginine codon to Leu at p.270 of the Vdr gene.
ASSOCIATED WITH abnormal cartilage morphology; abnormal femur morphology; abnormal trabecular bone morphology; ASSOCIATED WITH vitamin D-dependent rickets type 2A
Type: allele  of Vdr  
Previously known as: Vdr^[em1Thka]
Is Marker For: Strains:   W-Vdrem1Thka  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions. Nishikawa M, etal., Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1.


Related Rat Strains
The following Strains have been annotated to Vdrem1Thka



Nucleotide Sequences

Additional Information