Nsun4 (NOP2/Sun RNA methyltransferase 4) - Rat Genome Database

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Gene: Nsun4 (NOP2/Sun RNA methyltransferase 4) Ictidomys tridecemlineatus
Analyze
Symbol: Nsun4
Name: NOP2/Sun RNA methyltransferase 4
RGD ID: 12461859
Description: ENCODES a protein that exhibits rRNA (cytosine-C5-)-methyltransferase activity (ortholog); small ribosomal subunit rRNA binding (ortholog); INVOLVED IN cytosolic ribosome assembly (ortholog); positive regulation of mitochondrial translation (ortholog); FOUND IN mitochondrial large ribosomal subunit (inferred); mitochondrial matrix (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5-methylcytosine rRNA methyltransferase NSUN4; NOP2/Sun RNA methyltransferase family member 4; NOP2/Sun RNA methyltransferase family member 4, transcript variant X1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,531,932 - 61,561,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,356,134 - 27,387,098 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,356,133 - 27,385,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nsun4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,531,932 - 61,561,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,356,134 - 27,387,098 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,356,133 - 27,385,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSUN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,340,807 - 46,385,199 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,340,789 - 46,369,218 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,806,479 - 46,850,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,578,977 - 46,603,277 (+)NCBINCBI36Build 36hg18NCBI36
Build 34146,518,409 - 46,542,710NCBI
Celera145,093,753 - 45,118,052 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef144,921,478 - 44,946,447 (+)NCBIHuRef
CHM1_1146,922,865 - 46,947,850 (+)NCBICHM1_1
T2T-CHM13v2.0146,218,025 - 46,262,412 (+)NCBIT2T-CHM13v2.0
Nsun4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,890,202 - 115,911,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,890,039 - 115,911,073 (-)EnsemblGRCm39 Ensembl
GRCm384116,033,002 - 116,053,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,032,842 - 116,053,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv374115,704,375 - 115,726,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,530,774 - 115,551,808 (-)NCBIMGSCv36mm8
Celera4114,770,482 - 114,792,136 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.1NCBI
Nsun4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,749,024 - 134,773,630 (-)NCBIGRCr8
mRatBN7.25129,511,224 - 129,532,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,512,826 - 129,532,228 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl5129,512,307 - 129,532,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,128,516 - 132,148,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,883,402 - 133,903,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,905,539 - 133,925,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,885,377 - 134,905,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,886,497 - 134,905,588 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,362,680 - 134,382,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,669,115 - 138,689,234 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05138,152,068 - 138,174,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,277,224 - 136,297,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5128,042,563 - 128,062,561 (-)NCBICelera
Cytogenetic Map5q35NCBI
Nsun4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,932,429 - 11,967,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,934,146 - 11,962,513 (-)NCBIChiLan1.0ChiLan1.0
NSUN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,407,967 - 180,469,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,549,575 - 179,611,046 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,642,980 - 45,696,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,999,724 - 47,024,152 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,999,749 - 47,024,152 (+)Ensemblpanpan1.1panPan2
NSUN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,054,061 - 14,069,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,056,004 - 14,068,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,174,443 - 14,193,244 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,204,565 - 14,223,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,204,565 - 14,223,007 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,005,796 - 14,024,334 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,074,309 - 14,092,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,143,770 - 14,162,312 (-)NCBIUU_Cfam_GSD_1.0
NSUN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,091,797 - 165,118,861 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,093,511 - 165,119,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,572,652 - 152,598,585 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSUN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12086,432,047 - 86,453,481 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2086,432,414 - 86,453,157 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603330,537,494 - 30,565,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsun4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,230,429 - 2,251,296 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249062,231,040 - 2,254,083 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000009791   ⟹   ENSSTOP00000008780
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647427,356,134 - 27,387,098 (+)Ensembl
RefSeq Acc Id: XM_005317989   ⟹   XP_005318046
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505861,531,932 - 61,561,749 (+)NCBI
SpeTri2.0NW_00493647427,356,137 - 27,385,710 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040288604   ⟹   XP_040144538
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505861,535,015 - 61,561,758 (+)NCBI
RefSeq Acc Id: XM_040288605   ⟹   XP_040144539
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505861,531,932 - 61,552,933 (+)NCBI
RefSeq Acc Id: XM_040288606   ⟹   XP_040144540
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505861,531,932 - 61,552,770 (+)NCBI
RefSeq Acc Id: XR_001230175
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505861,531,932 - 61,560,355 (+)NCBI
SpeTri2.0NW_00493647427,356,133 - 27,385,710 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005735167
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505861,532,070 - 61,536,138 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005318046 (Get FASTA)   NCBI Sequence Viewer  
  XP_040144538 (Get FASTA)   NCBI Sequence Viewer  
  XP_040144539 (Get FASTA)   NCBI Sequence Viewer  
  XP_040144540 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000008780.3
GenBank Protein KAG3283068 (Get FASTA)   NCBI Sequence Viewer  
  KAG3283069 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005318046   ⟸   XM_005317989
- Peptide Label: isoform X1
- UniProtKB: I3ME83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040144539   ⟸   XM_040288605
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040144540   ⟸   XM_040288606
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040144538   ⟸   XM_040288604
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000008780   ⟸   ENSSTOT00000009791
Protein Domains
SAM-dependent MTase RsmB/NOP-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009794 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009791.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  6.20.240.40 UniProtKB/TrEMBL
InterPro MeTrfase_RsmB-F_NOP2_cat UniProtKB/TrEMBL
  MeTrfase_RsmB/NOP2 UniProtKB/TrEMBL
  RCMT UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
NCBI Gene Nsun4 ENTREZGENE
PANTHER 5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4 UniProtKB/TrEMBL
  NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam Methyltr_RsmB-F UniProtKB/TrEMBL
PRINTS RCMTFAMILY UniProtKB/TrEMBL
PROSITE SAM_MT_RSMB_NOP UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt I3ME83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-05 Nsun4  NOP2/Sun RNA methyltransferase 4    NOP2/Sun RNA methyltransferase family member 4  Symbol and/or name change 5135510 APPROVED