Srd5a2 (steroid 5 alpha-reductase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Srd5a2 (steroid 5 alpha-reductase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Srd5a2
Name: steroid 5 alpha-reductase 2
RGD ID: 12450140
Description: ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); biphenyl metabolic process (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATED WITH alopecia (ortholog); autism spectrum disorder (ortholog); Autoinflammation with Infantile Enterocolitis (ortholog); FOUND IN cell body fiber (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,130,023 - 69,175,570 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,663,911 - 1,708,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,663,999 - 1,708,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Srd5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,130,023 - 69,175,570 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,663,911 - 1,708,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,663,999 - 1,708,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38231,522,480 - 31,663,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl231,522,480 - 31,580,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37231,747,550 - 31,806,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,603,160 - 31,659,544 (-)NCBINCBI36Build 36hg18NCBI36
Build 34231,661,306 - 31,717,691NCBI
Celera231,590,884 - 31,647,296 (-)NCBICelera
Cytogenetic Map2p23.1NCBI
HuRef231,485,637 - 31,542,001 (-)NCBIHuRef
CHM1_1231,678,089 - 31,734,473 (-)NCBICHM1_1
T2T-CHM13v2.0231,567,195 - 31,707,768 (-)NCBIT2T-CHM13v2.0
Srd5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,321,886 - 74,354,855 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,323,950 - 74,354,911 (-)EnsemblGRCm39 Ensembl
GRCm381774,014,891 - 74,047,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1774,016,955 - 74,047,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,367,046 - 74,397,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361773,922,606 - 73,952,814 (-)NCBIMGSCv36mm8
Celera1778,309,438 - 78,339,442 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.39NCBI
Srd5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8627,178,089 - 27,217,588 (+)NCBIGRCr8
mRatBN7.2621,426,225 - 21,465,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,755,011 - 21,794,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0622,070,851 - 22,110,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,551,287 - 21,590,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q13NCBI
Srd5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,443 - 95,743 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544112,149 - 95,733 (-)NCBIChiLan1.0ChiLan1.0
SRD5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21294,913,580 - 94,967,170 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A94,917,555 - 94,971,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A31,542,646 - 31,597,394 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A31,610,487 - 31,665,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A31,610,487 - 31,665,718 (-)Ensemblpanpan1.1panPan2
SRD5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11725,017,113 - 25,056,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1725,017,113 - 25,056,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,811,155 - 24,850,233 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01725,580,015 - 25,620,097 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,580,843 - 25,620,171 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11724,887,475 - 24,926,628 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01724,946,476 - 24,985,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01725,049,043 - 25,087,911 (-)NCBIUU_Cfam_GSD_1.0
SRD5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,840,200 - 107,918,350 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,840,200 - 107,918,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,644,279 - 114,657,350 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11475,915,495 - 75,971,280 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1475,917,260 - 75,970,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604536,088,943 - 36,288,753 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473813,253,729 - 13,321,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473813,254,998 - 13,321,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005322474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000028918   ⟹   ENSSTOP00000022311
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364931,663,911 - 1,708,502 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000042949   ⟹   ENSSTOP00000025634
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364931,663,911 - 1,703,097 (+)Ensembl
RefSeq Acc Id: XM_005322474   ⟹   XP_005322531
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629269,130,023 - 69,175,570 (-)NCBI
SpeTri2.0NW_0049364931,663,999 - 1,708,530 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005322531 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022311.2
  ENSSTOP00000025634.1
RefSeq Acc Id: XP_005322531   ⟸   XM_005322474
- UniProtKB: I3ND64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000022311   ⟸   ENSSTOT00000028918
Ensembl Acc Id: ENSSTOP00000025634   ⟸   ENSSTOT00000042949
Protein Domains
3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028843 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028918.2 UniProtKB/TrEMBL
  ENSSTOT00000042949.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1630 UniProtKB/TrEMBL
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/TrEMBL
  3-oxo-5_a-steroid_4-DH_C UniProtKB/TrEMBL
  SRD5A/TECR UniProtKB/TrEMBL
NCBI Gene Srd5a2 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 2 UniProtKB/TrEMBL
  PTHR10556 UniProtKB/TrEMBL
Pfam Steroid_dh UniProtKB/TrEMBL
PIRSF 5_alpha-SR2 UniProtKB/TrEMBL
PROSITE S5A_REDUCTASE UniProtKB/TrEMBL
UniProt A0A287CWJ4_ICTTR UniProtKB/TrEMBL
  I3ND64 ENTREZGENE, UniProtKB/TrEMBL