ABCC3 (ATP binding cassette subfamily C member 3) - Rat Genome Database

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Gene: ABCC3 (ATP binding cassette subfamily C member 3) Canis lupus familiaris
Analyze
Symbol: ABCC3
Name: ATP binding cassette subfamily C member 3
RGD ID: 12429652
Description: ENCODES a protein that exhibits ABC-type bile acid transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); canalicular bile acid transport (ortholog); monoatomic anion transmembrane transport (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); autism spectrum disorder (ortholog); bilirubin metabolic disorder (ortholog); FOUND IN basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: canalicular multispecific organic anion transporter 2; multidrug resistance protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,551,953 - 26,596,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16446074   PMID:16971569   PMID:22301074   PMID:23373631   PMID:23773525   PMID:30032202  


Genomics

Comparative Map Data
ABCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,551,953 - 26,596,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBIUU_Cfam_GSD_1.0
ABCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,634,881 - 50,692,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,634,777 - 50,692,253 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,712,242 - 48,769,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,067,227 - 46,124,062 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,067,226 - 46,124,061NCBI
Celera1745,173,593 - 45,230,401 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,080,218 - 44,136,477 (+)NCBIHuRef
CHM1_11748,776,209 - 48,833,053 (+)NCBICHM1_1
T2T-CHM13v2.01751,502,046 - 51,559,449 (+)NCBIT2T-CHM13v2.0
Abcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,234,121 - 94,283,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,234,121 - 94,283,823 (-)EnsemblGRCm39 Ensembl
GRCm381194,343,295 - 94,393,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,343,295 - 94,392,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,204,609 - 94,254,290 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,159,385 - 94,209,066 (-)NCBIMGSCv36mm8
Celera11103,962,067 - 104,011,589 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.9NCBI
Abcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,793,571 - 79,839,528 (-)NCBIGRCr8
mRatBN7.21079,296,681 - 79,342,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,901,889 - 83,947,612 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,400,010 - 83,445,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,914,311 - 78,960,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
Abcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,087,570 - 11,130,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,087,246 - 11,130,108 (-)NCBIChiLan1.0ChiLan1.0
ABCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,826,417 - 66,883,666 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,633,385 - 71,690,669 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1749,603,268 - 49,659,318 (+)Ensemblpanpan1.1panPan2
Abcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,988,457 - 26,035,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,040,445 - 11,086,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,920,821 - 26,979,602 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,920,764 - 26,978,389 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,060,930 - 27,117,540 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,646,316 - 42,703,124 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,646,812 - 42,702,852 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,362,436 - 13,419,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,516,224 - 6,557,892 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,516,384 - 6,558,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABCC3
554 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005624674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022423112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ225112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000027259   ⟹   ENSCAFP00000025351
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000046338   ⟹   ENSCAFP00000038180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025981   ⟹   ENSCAFP00845020480
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845026050   ⟹   ENSCAFP00845020541
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)Ensembl
RefSeq Acc Id: XM_005624674   ⟹   XP_005624731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1926,551,953 - 26,596,330 (+)NCBI
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022423112   ⟹   XP_022278820
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1926,566,338 - 26,596,330 (+)NCBI
Dog10K_Boxer_Tasha925,958,948 - 25,988,893 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038485900   ⟹   XP_038341828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBI
RefSeq Acc Id: XM_038485901   ⟹   XP_038341829
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1926,128,112 - 26,158,047 (+)NCBI
RefSeq Acc Id: XM_038547687   ⟹   XP_038403615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBI
RefSeq Acc Id: XM_038547688   ⟹   XP_038403616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0926,517,154 - 26,547,109 (+)NCBI
RefSeq Acc Id: XM_038611659   ⟹   XP_038467587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBI
RefSeq Acc Id: XM_038611660   ⟹   XP_038467588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0926,386,808 - 26,416,803 (+)NCBI
RefSeq Acc Id: XM_038676884   ⟹   XP_038532812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBI
RefSeq Acc Id: XM_038676885   ⟹   XP_038532813
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0927,360,646 - 27,390,624 (+)NCBI
RefSeq Acc Id: XP_005624731   ⟸   XM_005624674
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NRM3 (UniProtKB/TrEMBL),   A0A8P0SLR2 (UniProtKB/TrEMBL),   A0A8C0TW46 (UniProtKB/TrEMBL),   A0A8P0SST7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278820   ⟸   XM_022423112
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TW46 (UniProtKB/TrEMBL),   A0A8P0SST7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000025351   ⟸   ENSCAFT00000027259
Ensembl Acc Id: ENSCAFP00000038180   ⟸   ENSCAFT00000046338
RefSeq Acc Id: XP_038341828   ⟸   XM_038485900
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038341829   ⟸   XM_038485901
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038467587   ⟸   XM_038611659
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038467588   ⟸   XM_038611660
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038532812   ⟸   XM_038676884
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S0X8 (UniProtKB/TrEMBL),   A0A8I3RY64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532813   ⟸   XM_038676885
- Peptide Label: isoform X2
- UniProtKB: A0A8I3RY64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403615   ⟸   XM_038547687
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NRM3 (UniProtKB/TrEMBL),   A0A8C0TW46 (UniProtKB/TrEMBL),   A0A8P0SLR2 (UniProtKB/TrEMBL),   A0A8P0SST7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403616   ⟸   XM_038547688
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TW46 (UniProtKB/TrEMBL),   A0A8P0SST7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845020480   ⟸   ENSCAFT00845025981
Ensembl Acc Id: ENSCAFP00845020541   ⟸   ENSCAFT00845026050
Promoters
RGD ID:13684596
Promoter ID:EPDNEW_C2664
Type:initiation region
Name:ABCC3_1
Description:ATP binding cassette subfamily C member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1926,552,018 - 26,552,078EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017201 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016342 UniProtKB/TrEMBL
  ENSCAFG00040025860 UniProtKB/TrEMBL
  ENSCAFG00845014515 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027259.5 UniProtKB/TrEMBL
  ENSCAFT00000046338.4 UniProtKB/TrEMBL
  ENSCAFT00030030105.1 UniProtKB/TrEMBL
  ENSCAFT00030030296.1 UniProtKB/TrEMBL
  ENSCAFT00040048349.1 UniProtKB/TrEMBL
  ENSCAFT00040048362.1 UniProtKB/TrEMBL
  ENSCAFT00040048370.1 UniProtKB/TrEMBL
  ENSCAFT00845025981 ENTREZGENE
  ENSCAFT00845025981.1 UniProtKB/TrEMBL
  ENSCAFT00845026050.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_C UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:491084 UniProtKB/TrEMBL
NCBI Gene ABCC3 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A8C0NGH1_CANLF UniProtKB/TrEMBL
  A0A8C0NRM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TW46 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TY59_CANLF UniProtKB/TrEMBL
  A0A8I3RY64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S0X8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SLR2 ENTREZGENE
  A0A8P0SST7 ENTREZGENE
  Q38IV3_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0SLR2 UniProtKB/TrEMBL
  A0A8P0SST7 UniProtKB/TrEMBL
VGNC ID VGNC:49912 ENTREZGENE