NUCB1 (nucleobindin 1) - Rat Genome Database

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Gene: NUCB1 (nucleobindin 1) Canis lupus familiaris
Analyze
Symbol: NUCB1
Name: nucleobindin 1
RGD ID: 12428538
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); G-protein alpha-subunit binding (ortholog); INVOLVED IN regulation of protein targeting (ortholog); small GTPase-mediated signal transduction (ortholog); ASSOCIATED WITH Stevens-Johnson syndrome (ortholog); FOUND IN early endosome (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleobindin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,453,965 - 107,476,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,454,636 - 107,476,375 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,976,497 - 106,999,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,978,613 - 108,001,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,978,615 - 108,001,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,646,057 - 107,668,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,292,476 - 107,315,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,128,088 - 108,150,670 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NUCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,453,965 - 107,476,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,454,636 - 107,476,375 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,976,497 - 106,999,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,978,613 - 108,001,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,978,615 - 108,001,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,646,057 - 107,668,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,292,476 - 107,315,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,128,088 - 108,150,670 (-)NCBIUU_Cfam_GSD_1.0
NUCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,900,312 - 48,923,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,900,050 - 48,923,473 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,403,569 - 49,426,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,091,637 - 54,118,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,095,852 - 54,118,337NCBI
Celera1946,270,663 - 46,293,902 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,779,769 - 45,802,972 (+)NCBIHuRef
CHM1_11949,405,174 - 49,428,729 (+)NCBICHM1_1
T2T-CHM13v2.01951,895,140 - 51,918,232 (+)NCBIT2T-CHM13v2.0
Nucb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,142,300 - 45,159,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,139,882 - 45,159,830 (-)EnsemblGRCm39 Ensembl
GRCm38745,492,674 - 45,510,408 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,490,458 - 45,510,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,748,044 - 52,765,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,361,150 - 45,378,372 (-)NCBIMGSCv36mm8
Celera740,949,201 - 40,966,928 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.33NCBI
Nucb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,104,793 - 105,135,730 (-)NCBIGRCr8
mRatBN7.2195,968,325 - 95,999,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,353,752 - 101,373,866 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,826,428 - 109,846,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,116,822 - 103,136,934 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,480,160 - 101,511,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,559,072 - 102,579,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,961,163 - 95,981,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,039,273 - 96,060,021 (-)NCBI
Celera190,224,246 - 90,244,279 (-)NCBICelera
Cytogenetic Map1q22NCBI
Nucb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,722,411 - 1,740,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,723,986 - 1,739,776 (-)NCBIChiLan1.0ChiLan1.0
NUCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,003,893 - 55,026,955 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,930,112 - 56,953,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,900,098 - 45,923,056 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,831,582 - 54,856,711 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,832,426 - 54,855,962 (-)Ensemblpanpan1.1panPan2
Nucb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,305,942 - 21,327,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,924,719 - 2,945,178 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,924,186 - 2,946,035 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,180,038 - 54,209,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,186,610 - 54,209,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,119,224 - 50,141,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,133,505 - 42,154,461 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,017,037 - 22,040,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nucb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,071,869 - 5,085,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,073,022 - 5,085,493 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NUCB1
362 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006233   ⟹   ENSCAFP00000005773
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1107,454,636 - 107,476,375 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845000899   ⟹   ENSCAFP00845000673
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1107,978,615 - 108,001,085 (-)Ensembl
RefSeq Acc Id: XM_038467600   ⟹   XP_038323528
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,646,057 - 107,668,201 (-)NCBI
RefSeq Acc Id: XM_038528315   ⟹   XP_038384243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01108,128,088 - 108,150,670 (-)NCBI
RefSeq Acc Id: XM_038592605   ⟹   XP_038448533
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01107,292,476 - 107,315,053 (-)NCBI
RefSeq Acc Id: XM_038656396   ⟹   XP_038512324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,978,613 - 108,001,223 (-)NCBI
RefSeq Acc Id: XM_541506   ⟹   XP_541506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11107,453,965 - 107,476,458 (-)NCBI
Dog10K_Boxer_Tasha1106,976,497 - 106,999,075 (-)NCBI
Sequence:
RefSeq Acc Id: XP_541506   ⟸   XM_541506
- UniProtKB: A0A8C0PVG8 (UniProtKB/TrEMBL),   A0A8I3RP80 (UniProtKB/TrEMBL),   A0A8C0LPQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000005773   ⟸   ENSCAFT00000006233
RefSeq Acc Id: XP_038323528   ⟸   XM_038467600
RefSeq Acc Id: XP_038448533   ⟸   XM_038592605
RefSeq Acc Id: XP_038512324   ⟸   XM_038656396
- UniProtKB: A0A8C0PVG8 (UniProtKB/TrEMBL),   A0A8I3RP80 (UniProtKB/TrEMBL),   A0A8C0LPQ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384243   ⟸   XM_038528315
- UniProtKB: A0A8C0LPQ9 (UniProtKB/TrEMBL),   A0A8C0PVG8 (UniProtKB/TrEMBL),   A0A8I3RP80 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845000673   ⟸   ENSCAFT00845000899
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003874 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013967 UniProtKB/TrEMBL
  ENSCAFG00040000673 UniProtKB/TrEMBL
  ENSCAFG00845000560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006233.5 UniProtKB/TrEMBL
  ENSCAFT00030025861.1 UniProtKB/TrEMBL
  ENSCAFT00030025972.1 UniProtKB/TrEMBL
  ENSCAFT00040001216.1 UniProtKB/TrEMBL
  ENSCAFT00845000899 ENTREZGENE
  ENSCAFT00845000899.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Nucleobindin UniProtKB/TrEMBL
KEGG Report cfa:484391 UniProtKB/TrEMBL
NCBI Gene NUCB1 ENTREZGENE
PANTHER PTHR19237 UniProtKB/TrEMBL
  PTHR19237:SF21 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C0LPQ9 ENTREZGENE
  A0A8C0N737_CANLF UniProtKB/TrEMBL
  A0A8C0PVG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RP80 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53746 ENTREZGENE