BCHE (butyrylcholinesterase) - Rat Genome Database

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Gene: BCHE (butyrylcholinesterase) Canis lupus familiaris
Analyze
Symbol: BCHE
Name: butyrylcholinesterase
RGD ID: 12425628
Description: ENCODES a protein that exhibits acetylcholinesterase activity (ortholog); choline binding (ortholog); cholinesterase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); learning (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN heroin pharmacodynamics pathway; heroin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Acholinesterasemia (ortholog); Alzheimer's disease (ortholog); amnestic disorder (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); extracellular space (ortholog); INTERACTS WITH Butyrylcholine; butyrylthiocholine; dichlorvos
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acylcholine acylhydrolase; butylcholinesterase; butyrylcholine esterase; choline esterase II; cholinesterase; pseudocholinesterase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13430,912,632 - 30,977,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3430,912,632 - 30,977,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3439,973,463 - 40,038,402 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03430,973,335 - 31,038,334 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3430,972,845 - 31,038,271 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13430,917,722 - 30,976,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03430,878,067 - 30,943,017 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03431,141,049 - 31,206,522 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acholinesterasemia  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Amyloid Plaques  (ISO)
Apnea  (ISO)
autism spectrum disorder  (ISO)
bacterial meningitis  (ISO)
Bamforth-Lazarus syndrome  (ISO)
Breast Neoplasms  (ISO)
Butyrylcholinesterase Deficiency  (ISO)
Butyrylcholinesterase Deficiency, Fluoride-Resistant, Japanese Type  (ISO)
cannabis abuse  (ISO)
Cardiotoxicity  (ISO)
cocaine abuse  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Death  (ISO)
dementia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dystonia  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
Fasciculation  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (ISO)
leptospirosis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
muscular dystrophy  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Organophosphate Poisoning  (ISO)
Paralysis  (ISO)
Paresis  (ISO)
Poisoning  (ISO)
Postoperative Complications  (ISO)
primary progressive multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
secondary Parkinson disease  (ISO)
sleep apnea  (ISO)
Stroke  (ISO)
Tachycardia  (ISO)
toxic encephalopathy  (ISO)
Trismus  (ISO)
trypanosomiasis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2016308   PMID:21820337   PMID:26616656   PMID:30032202   PMID:31789474  


Genomics

Comparative Map Data
BCHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13430,912,632 - 30,977,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3430,912,632 - 30,977,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3439,973,463 - 40,038,402 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03430,973,335 - 31,038,334 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3430,972,845 - 31,038,271 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13430,917,722 - 30,976,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03430,878,067 - 30,943,017 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03431,141,049 - 31,206,522 (-)NCBIUU_Cfam_GSD_1.0
BCHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383165,772,904 - 165,837,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3165,772,904 - 165,837,462 (-)EnsemblGRCh38hg38GRCh38
GRCh373165,490,692 - 165,555,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363166,973,386 - 167,037,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 343166,973,394 - 167,037,952NCBI
Celera3163,889,280 - 163,954,027 (-)NCBICelera
Cytogenetic Map3q26.1NCBI
HuRef3162,859,251 - 162,924,002 (-)NCBIHuRef
CHM1_13165,453,437 - 165,518,145 (-)NCBICHM1_1
T2T-CHM13v2.03168,555,830 - 168,620,600 (-)NCBIT2T-CHM13v2.0
Bche
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39373,543,138 - 73,615,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl373,543,141 - 73,615,748 (-)EnsemblGRCm39 Ensembl
GRCm38373,635,805 - 73,708,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl373,635,808 - 73,708,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37373,439,731 - 73,512,337 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36373,721,734 - 73,794,168 (-)NCBIMGSCv36mm8
Celera373,748,016 - 73,817,761 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map333.61NCBI
Bche
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82160,607,289 - 160,699,760 (-)NCBIGRCr8
mRatBN7.22158,308,674 - 158,401,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2158,307,584 - 158,401,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2165,439,220 - 165,525,241 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02163,487,797 - 163,573,811 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02158,120,569 - 158,206,587 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02171,104,476 - 171,196,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2171,100,140 - 171,196,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02190,443,044 - 190,536,106 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42164,329,613 - 164,427,994 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12164,279,575 - 164,377,957 (-)NCBI
Celera2152,547,587 - 152,638,478 (-)NCBICelera
Cytogenetic Map2q32NCBI
Bche
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544815,329,273 - 15,396,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544815,327,374 - 15,396,827 (-)NCBIChiLan1.0ChiLan1.0
BCHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22163,667,263 - 163,731,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13163,670,621 - 163,736,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03162,794,184 - 162,858,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13170,845,494 - 170,910,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,845,494 - 170,911,481 (-)Ensemblpanpan1.1panPan2
Bche
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560297,068,925 - 97,127,830 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367071,854,444 - 1,913,460 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367071,784,338 - 1,913,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113104,946,732 - 105,007,568 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213113,411,303 - 113,471,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCHE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11523,708,121 - 23,778,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1523,708,155 - 23,778,286 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606332,661,071 - 32,730,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bche
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473043,793,040 - 43,843,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473043,793,550 - 43,849,169 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BCHE
1050 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023011   ⟹   ENSCAFP00000021376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3430,912,632 - 30,977,583 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845032535   ⟹   ENSCAFP00845025442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3430,972,845 - 31,038,271 (-)Ensembl
RefSeq Acc Id: NM_001313861   ⟹   NP_001300790
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13430,912,632 - 30,977,583 (-)NCBI
Dog10K_Boxer_Tasha3439,973,463 - 40,038,402 (-)NCBI
ROS_Cfam_1.03430,973,335 - 31,038,311 (-)NCBI
UMICH_Zoey_3.13430,917,722 - 30,976,598 (-)NCBI
UNSW_CanFamBas_1.03430,878,067 - 30,943,017 (-)NCBI
UU_Cfam_GSD_1.03431,141,049 - 31,206,522 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445397   ⟹   XP_038301325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03430,980,426 - 31,038,334 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001300790 (Get FASTA)   NCBI Sequence Viewer  
  XP_038301325 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51451 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000021376.3
  ENSCAFP00030021747.1
  ENSCAFP00040037061.1
  ENSCAFP00845025442
  ENSCAFP00845025442.1
GenBank Protein P32750 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001300790   ⟸   NM_001313861
- Peptide Label: precursor
- UniProtKB: A0A8C0NAH8 (UniProtKB/TrEMBL),   A0A8I3PBA0 (UniProtKB/TrEMBL),   A0A8C0L952 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021376   ⟸   ENSCAFT00000023011
RefSeq Acc Id: XP_038301325   ⟸   XM_038445397
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L952 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845025442   ⟸   ENSCAFT00845032535
Protein Domains
Acetylcholinesterase tetramerisation   Carboxylesterase type B

Promoters
RGD ID:13688931
Promoter ID:EPDNEW_C6999
Type:multiple initiation site
Name:BCHE_1
Description:butyrylcholinesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13430,977,545 - 30,977,605EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014473 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013461 UniProtKB/TrEMBL
  ENSCAFG00040022859 UniProtKB/TrEMBL
  ENSCAFG00845018401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023011.5 UniProtKB/TrEMBL
  ENSCAFT00030024903.1 UniProtKB/TrEMBL
  ENSCAFT00040042491.1 UniProtKB/TrEMBL
  ENSCAFT00845032535 ENTREZGENE
  ENSCAFT00845032535.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AChE-related_enzymes UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AChE_tetra UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cholinesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:488143 UniProtKB/TrEMBL
NCBI Gene BCHE ENTREZGENE
PANTHER ACETYLCHOLINESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHOLINESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AChE_tetra UniProtKB/TrEMBL
  COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHOLNESTRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0L952 ENTREZGENE
  A0A8C0NAH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PBA0 ENTREZGENE, UniProtKB/TrEMBL
  CHLE_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:38405 ENTREZGENE