EZR (ezrin) - Rat Genome Database

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Pathways
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Gene: EZR (ezrin) Canis lupus familiaris
Analyze
Symbol: EZR
Name: ezrin
RGD ID: 12414357
Description: ENCODES a protein that exhibits disordered domain specific binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); establishment or maintenance of apical/basal cell polarity (ortholog); PARTICIPATES IN FasL mediated signaling pathway; parathyroid hormone signaling pathway; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: VIL2; villin 2 (ezrin)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,160,206 - 48,210,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,346,327 - 48,397,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
actin filament bundle assembly  (IEA)
astral microtubule organization  (IEA)
cellular response to cAMP  (IEA)
cortical microtubule organization  (IEA)
epithelial cell differentiation  (ISO)
establishment of centrosome localization  (IEA)
establishment of endothelial barrier  (IEA)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
filopodium assembly  (IEA,ISO)
gland morphogenesis  (ISO)
intestinal D-glucose absorption  (ISO)
leukocyte cell-cell adhesion  (IEA)
membrane to membrane docking  (IEA)
microvillus assembly  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of interleukin-2 production  (IEA)
negative regulation of p38MAPK cascade  (IEA)
negative regulation of T cell receptor signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of early endosome to late endosome transport  (IBA,IEA)
positive regulation of gene expression  (IEA)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein localization to early endosome  (IBA,IEA)
positive regulation of protein localization to plasma membrane  (ISO)
postsynaptic actin cytoskeleton organization  (ISO)
protein kinase A signaling  (IEA)
protein localization to cell cortex  (IEA)
protein localization to plasma membrane  (IEA)
protein-containing complex localization  (IEA)
receptor internalization  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell shape  (IBA,IEA)
regulation of cell size  (ISO)
regulation of microvillus length  (ISO)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of organelle assembly  (IBA,IEA)
sphingosine-1-phosphate receptor signaling pathway  (IEA)
terminal web assembly  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15233990   PMID:21848623   PMID:21979959   PMID:22236104   PMID:22301074   PMID:26435322   PMID:27900754   PMID:30032202   PMID:37756605  


Genomics

Comparative Map Data
EZR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,160,206 - 48,210,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,346,327 - 48,397,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBIUU_Cfam_GSD_1.0
EZR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386158,765,748 - 158,819,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6158,765,741 - 158,819,368 (-)EnsemblGRCh38hg38GRCh38
GRCh376159,186,780 - 159,240,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366159,106,764 - 159,159,247 (-)NCBINCBI36Build 36hg18NCBI36
Build 346159,157,186 - 159,209,668NCBI
Celera6159,834,789 - 159,888,323 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6156,657,307 - 156,711,123 (-)NCBIHuRef
CHM1_16159,449,491 - 159,503,058 (-)NCBICHM1_1
T2T-CHM13v2.06160,010,984 - 160,064,812 (-)NCBIT2T-CHM13v2.0
Ezr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,005,530 - 7,050,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,005,440 - 7,050,183 (-)EnsemblGRCm39 Ensembl
GRCm38176,738,131 - 6,782,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl176,738,041 - 6,782,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv37176,942,480 - 6,987,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36176,587,789 - 6,632,438 (-)NCBIMGSCv36mm8
Celera1514,687,905 - 14,732,667 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.38NCBI
Ezr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,373,033 - 49,416,573 (-)NCBIGRCr8
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx147,516,906 - 47,560,444 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,504,177 - 53,547,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,592,352 - 47,635,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Celera142,655,531 - 42,699,079 (-)NCBICelera
Cytogenetic Map1q11NCBI
Ezr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554393,703,013 - 3,740,345 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554393,701,722 - 3,740,345 (+)NCBIChiLan1.0ChiLan1.0
EZR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25178,869,668 - 178,923,683 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16176,774,286 - 176,828,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06156,656,146 - 156,709,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16161,670,483 - 161,723,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)Ensemblpanpan1.1panPan2
Ezr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,458,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18,403,453 - 8,452,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118,403,362 - 8,452,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2110,423,530 - 10,432,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EZR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11386,342,954 - 86,399,827 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1386,344,051 - 86,370,622 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604058,721,321 - 58,778,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624929826,531 - 873,572 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624929827,275 - 873,743 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EZR
501 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000001022   ⟹   ENSCAFP00000000937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845002394   ⟹   ENSCAFP00845001902
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl148,346,327 - 48,397,690 (-)Ensembl
RefSeq Acc Id: NM_001286989   ⟹   NP_001273918
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1148,160,206 - 48,210,036 (-)NCBI
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBI
ROS_Cfam_1.0148,346,325 - 48,396,423 (-)NCBI
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBI
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBI
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038653509   ⟹   XP_038509437
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBI
RefSeq Acc Id: XM_038653511   ⟹   XP_038509439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0148,346,325 - 48,371,415 (-)NCBI
RefSeq Acc Id: NP_001273918   ⟸   NM_001286989
- UniProtKB: A0A8C0KVZ9 (UniProtKB/TrEMBL),   A0A8C0NAG2 (UniProtKB/TrEMBL),   A0A8I3MKE1 (UniProtKB/TrEMBL),   A0A8C0NG72 (UniProtKB/TrEMBL),   A0A8P0P204 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000000937   ⟸   ENSCAFT00000001022
RefSeq Acc Id: XP_038509437   ⟸   XM_038653509
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KVZ9 (UniProtKB/TrEMBL),   A0A8C0NAG2 (UniProtKB/TrEMBL),   A0A8I3MKE1 (UniProtKB/TrEMBL),   A0A8C0NG72 (UniProtKB/TrEMBL),   A0A8P0P204 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509439   ⟸   XM_038653511
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NQY6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845001902   ⟸   ENSCAFT00845002394
Protein Domains
Band 4.1   FERM   FERM C-terminal PH-like

Promoters
RGD ID:13682015
Promoter ID:EPDNEW_C82
Type:single initiation site
Name:EZR_1
Description:ezrin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1148,210,025 - 48,210,085EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000661 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014845 UniProtKB/TrEMBL
  ENSCAFG00040022040 UniProtKB/TrEMBL
  ENSCAFG00845001373 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001022.5 UniProtKB/TrEMBL
  ENSCAFT00000087260.2 UniProtKB/TrEMBL
  ENSCAFT00030027606.1 UniProtKB/TrEMBL
  ENSCAFT00030027698.1 UniProtKB/TrEMBL
  ENSCAFT00030027795.1 UniProtKB/TrEMBL
  ENSCAFT00030027897.1 UniProtKB/TrEMBL
  ENSCAFT00040041067.1 UniProtKB/TrEMBL
  ENSCAFT00040041098.1 UniProtKB/TrEMBL
  ENSCAFT00040041161.1 UniProtKB/TrEMBL
  ENSCAFT00845002394 ENTREZGENE
  ENSCAFT00845002394.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.450 UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.360.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  ERM UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/TrEMBL
  ERM_helical UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report cfa:484056 UniProtKB/TrEMBL
NCBI Gene EZR ENTREZGENE
PANTHER PTHR23281 UniProtKB/TrEMBL
Pfam ERM_C UniProtKB/TrEMBL
  ERM_helical UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
PIRSF ERM UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF48678 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C0KVZ9 ENTREZGENE
  A0A8C0NAG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NG72 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NQY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TGQ7_CANLF UniProtKB/TrEMBL
  A0A8I3MKE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P204 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40542 ENTREZGENE