EN1 (engrailed homeobox 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: EN1 (engrailed homeobox 1) Canis lupus familiaris
Analyze
Symbol: EN1
Name: engrailed homeobox 1
RGD ID: 12407720
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN embryonic limb morphogenesis (ortholog); midbrain development (ortholog); response to cocaine (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); ENDOVE SYNDROME, LIMB-BRAIN TYPE (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein engrailed-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,124,325 - 31,129,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,511,803 - 32,516,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,124,325 - 31,129,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,511,803 - 32,516,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
EN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,842,171 - 118,847,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,842,171 - 118,847,648 (-)Ensemblhg38GRCh38
GRCh372119,599,747 - 119,605,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,316,217 - 119,322,229 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342119,315,995 - 119,321,989NCBI
Celera2112,924,401 - 112,930,414 (-)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2111,924,919 - 111,930,585 (-)NCBIHuRef
CHM1_12119,603,429 - 119,609,441 (-)NCBICHM1_1
T2T-CHM13v2.02119,275,530 - 119,281,008 (-)NCBIT2T-CHM13v2.0
En1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,246 - 120,535,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)Ensemblmm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBIMGSCv36mm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
En1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,303,684 - 34,309,269 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1334,303,702 - 34,309,269 (+)EnsemblGRCr8
mRatBN7.21331,750,892 - 31,756,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1334,309,142 - 34,314,728 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,596,963 - 35,602,549 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,871,391 - 32,876,977 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)Ensemblrn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
En1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545910,839,581 - 10,844,208 (+)Ensembl
ChiLan1.0NW_00495545910,839,581 - 10,844,198 (+)NCBIChiLan1.0ChiLan1.0
EN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21320,867,576 - 20,875,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B20,882,547 - 20,888,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B5,798,557 - 5,804,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
En1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,166,409 - 90,170,431 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646951,439,944 - 51,451,194 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646951,439,944 - 51,451,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,402,370 - 24,407,692 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11524,402,605 - 24,408,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,041,846 - 28,047,020 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,470,295 - 11,558,688 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,475,221 - 11,479,475 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606111,121,703 - 11,124,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
En1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473226,333,653 - 26,337,904 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473226,333,642 - 26,338,450 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in EN1
46 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845051560   ⟹   ENSCAFP00845040455
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1932,511,803 - 32,516,949 (+)Ensembl
RefSeq Acc Id: XM_038425619   ⟹   XP_038281547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBI
RefSeq Acc Id: XM_038454769   ⟹   XP_038310697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBI
RefSeq Acc Id: XM_038502492   ⟹   XP_038358420
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBI
RefSeq Acc Id: XM_038564528   ⟹   XP_038420456
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBI
RefSeq Acc Id: XM_038628655   ⟹   XP_038484583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBI
RefSeq Acc Id: XP_038358420   ⟸   XM_038502492
RefSeq Acc Id: XP_038484583   ⟸   XM_038628655
RefSeq Acc Id: XP_038281547   ⟸   XM_038425619
- UniProtKB: A0A8I3Q5L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310697   ⟸   XM_038454769
- UniProtKB: A0A8C0KLH5 (UniProtKB/TrEMBL),   A0A8P0TQQ4 (UniProtKB/TrEMBL),   A0A8C0RPC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420456   ⟸   XM_038564528
- UniProtKB: A0A8C0QHB6 (UniProtKB/TrEMBL),   A0A8C0RPC2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845040455   ⟸   ENSCAFT00845051560
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000056000 UniProtKB/TrEMBL
  ENSCAFG00030020131 UniProtKB/TrEMBL
  ENSCAFG00040008141 UniProtKB/TrEMBL
  ENSCAFG00845029136 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000106544.1 UniProtKB/TrEMBL
  ENSCAFT00030036963.1 UniProtKB/TrEMBL
  ENSCAFT00040015225.1 UniProtKB/TrEMBL
  ENSCAFT00845051560.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Engrailed_Homeobox_TFs UniProtKB/TrEMBL
  Homeobox-engrailed_C-terminal UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_engrailed UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Homoebox-engrailed_CS UniProtKB/TrEMBL
NCBI Gene EN1 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ENGRAILED-1 UniProtKB/TrEMBL
Pfam Engrail_1_C_sig UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
PRINTS ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX UniProtKB/TrEMBL
PROSITE ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C0KLH5 ENTREZGENE
  A0A8C0QHB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RPC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q5L6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TQQ4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54804 ENTREZGENE