DPYS (dihydropyrimidinase) - Rat Genome Database

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Gene: DPYS (dihydropyrimidinase) Canis lupus familiaris
Analyze
Symbol: DPYS
Name: dihydropyrimidinase
RGD ID: 12403345
Description: ENCODES a protein that exhibits amino acid binding (ortholog); dihydropyrimidinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); dTMP catabolic process (ortholog); thymine catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH dihydropyrimidinase deficiency (ortholog); dihydropyrimidine dehydrogenase deficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha135,591,294 - 5,668,125 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0135,831,073 - 5,907,171 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,831,081 - 5,907,175 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,599,335 - 5,675,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,718,958 - 5,795,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,740,684 - 5,816,800 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
protein-containing complex  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DPYS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha135,591,294 - 5,668,125 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0135,831,073 - 5,907,171 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,831,081 - 5,907,175 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,599,335 - 5,675,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,718,958 - 5,795,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,740,684 - 5,816,800 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
DPYS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388104,379,431 - 104,467,055 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8104,329,333 - 104,467,111 (-)Ensemblhg38GRCh38
GRCh378105,391,659 - 105,479,283 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,460,829 - 105,548,453 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348105,460,828 - 105,548,453NCBI
Celera8101,578,319 - 101,665,933 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef8100,592,683 - 100,680,266 (-)NCBIHuRef
CHM1_18105,432,468 - 105,520,073 (-)NCBICHM1_1
T2T-CHM13v2.08105,506,922 - 105,594,550 (-)NCBIT2T-CHM13v2.0
Dpys
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,631,881 - 39,720,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1539,631,883 - 39,720,866 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381539,768,485 - 39,857,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,768,487 - 39,857,470 (-)Ensemblmm10GRCm38
MGSCv371539,600,031 - 39,689,016 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361539,598,559 - 39,687,541 (-)NCBIMGSCv36mm8
Celera1540,252,611 - 40,341,397 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.53NCBI
Dpys
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8772,707,566 - 72,814,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl772,721,048 - 72,814,142 (-)EnsemblGRCr8
mRatBN7.2770,822,648 - 70,929,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,835,789 - 70,929,231 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx772,734,091 - 72,812,164 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0774,936,581 - 75,014,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0774,804,671 - 74,882,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0778,769,918 - 78,847,941 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)Ensemblrn6Rnor6.0
Rnor_5.0778,796,405 - 78,873,615 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4775,368,238 - 75,446,160 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera767,904,867 - 67,982,691 (-)NCBICelera
RGSC_v3.1775,449,118 - 75,466,890 (-)NCBI
Cytogenetic Map7q31NCBI
Dpys
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,185,407 - 28,244,307 (-)Ensembl
ChiLan1.0NW_00495541728,183,771 - 28,244,309 (-)NCBIChiLan1.0ChiLan1.0
DPYS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27121,730,892 - 121,819,525 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1897,202,305 - 97,342,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08101,008,090 - 101,096,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18103,160,922 - 103,248,303 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,160,922 - 103,248,303 (-)EnsemblpanPan2panpan1.1
Dpys
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530332,138,098 - 32,211,295 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647039,564,335 - 39,637,544 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647039,564,431 - 39,637,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1432,791,152 - 32,879,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,528,834 - 35,616,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,216,623 - 99,303,969 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl899,216,354 - 99,303,282 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603941,267,984 - 41,354,516 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpys
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476320,620,380 - 20,680,782 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476320,618,515 - 20,680,790 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dpys
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11213,109,739 - 213,184,517 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in DPYS
837 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 4 22 22 16 6 6 6 6 28 17 11 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000001047   ⟹   ENSCAFP00000000959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017671   ⟹   ENSCAFP00845013757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl135,831,081 - 5,907,171 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017746   ⟹   ENSCAFP00845013822
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl135,831,095 - 5,907,175 (-)Ensembl
RefSeq Acc Id: XM_038428578   ⟹   XP_038284506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha135,591,294 - 5,668,125 (-)NCBI
RefSeq Acc Id: XM_038493055   ⟹   XP_038348983
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1135,599,335 - 5,675,944 (-)NCBI
RefSeq Acc Id: XM_038555313   ⟹   XP_038411241
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0135,740,684 - 5,816,800 (-)NCBI
RefSeq Acc Id: XM_038619212   ⟹   XP_038475140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0135,718,958 - 5,795,623 (-)NCBI
RefSeq Acc Id: XM_038684828   ⟹   XP_038540756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0135,831,073 - 5,907,171 (-)NCBI
Ensembl Acc Id: ENSCAFP00000000959   ⟸   ENSCAFT00000001047
RefSeq Acc Id: XP_038348983   ⟸   XM_038493055
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475140   ⟸   XM_038619212
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038540756   ⟸   XM_038684828
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RRV2 (UniProtKB/TrEMBL),   A0A8I3RVL6 (UniProtKB/TrEMBL),   A0A8I3NFU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284506   ⟸   XM_038428578
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RRV2 (UniProtKB/TrEMBL),   A0A8I3RVL6 (UniProtKB/TrEMBL),   A0A8I3NFU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411241   ⟸   XM_038555313
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RRV2 (UniProtKB/TrEMBL),   A0A8I3NFU2 (UniProtKB/TrEMBL),   A0A8I3RVL6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013757   ⟸   ENSCAFT00845017671
Ensembl Acc Id: ENSCAFP00845013822   ⟸   ENSCAFT00845017746
Protein Domains
Amidohydrolase-related

Promoters
RGD ID:13685569
Promoter ID:EPDNEW_C3638
Type:single initiation site
Name:DPYS_1
Description:dihydropyrimidinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1135,659,286 - 5,659,346EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000676 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023471 UniProtKB/TrEMBL
  ENSCAFG00845010050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001047.5 UniProtKB/TrEMBL
  ENSCAFT00030043124.1 UniProtKB/TrEMBL
  ENSCAFT00845017671.1 UniProtKB/TrEMBL
  ENSCAFT00845017746 ENTREZGENE
  ENSCAFT00845017746.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Hydantoinase/dihydroPyrase UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
  Metallo-dep_Hydrolases_sf UniProtKB/TrEMBL
NCBI Gene DPYS ENTREZGENE
PANTHER DIHYDROPYRIMIDINASE UniProtKB/TrEMBL
  HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam Amidohydro_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
UniProt A0A8C0RRV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NFU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RVL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N3X1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40082 ENTREZGENE