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Gene: GSDMD (gasdermin D) Canis lupus familiaris

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Symbol:

GSDMD

Name:

gasdermin D

RGD ID:

12403252

Description:

ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN positive regulation of interleukin-1 production (ortholog); positive regulation of interleukin-18 production (ortholog); ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); holoprosencephaly (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH ochratoxin A

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

gasdermin domain containing 1; gasdermin-D; GSDMDC1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GSDMD (gasdermin D)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,221,219 - 37,226,912 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,193,022 - 37,228,360 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	37,693,447 - 37,700,588 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brown-Vialetto-Van Laere syndrome 2 (ISO)

epidermolysis bullosa simplex with muscular dystrophy (ISO)

holoprosencephaly (ISO)

Recombinant Chromosome 8 Syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

ochratoxin A (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to bacterium (IBA)

defense response to Gram-negative bacterium (IEA)

defense response to Gram-positive bacterium (IEA)

pore complex assembly (IEA)

positive regulation of inflammatory response (IEA)

positive regulation of interleukin-1 beta production (IEA)

positive regulation of interleukin-1 production (ISO)

positive regulation of interleukin-18 production (ISO)

programmed cell death (IEA)

protein homooligomerization (IEA)

protein secretion (IEA)

pyroptotic cell death (IEA)

pyroptotic inflammatory response (IBA,IEA)

transmembrane transport (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

extracellular space (IEA)

membrane (IEA,ISO)

mitochondrial membrane (IEA)

NLRP3 inflammasome complex (IBA,IEA)

nucleoplasm (IEA)

plasma membrane (IEA,ISO)

Molecular Function

cardiolipin binding (IEA)

phosphatidic acid binding (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IBA,IEA)

phosphatidylinositol-4-phosphate binding (IBA,IEA)

phosphatidylserine binding (IBA,IEA)

protein binding (ISO)

transcription coactivator activity (ISO)

wide pore channel activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

GSDMD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,221,219 - 37,226,912 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,193,022 - 37,228,360 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	37,693,447 - 37,700,588 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI		UU_Cfam_GSD_1.0

GSDMD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	143,553,387 - 143,563,062 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	143,553,207 - 143,563,062 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	144,635,557 - 144,645,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	144,711,635 - 144,716,375 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	144,712,102 - 144,716,372	NCBI
Celera	8	140,945,843 - 140,955,486 (+)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	139,886,817 - 139,896,607 (+)	NCBI		HuRef
CHM1_1	8	144,675,788 - 144,685,442 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	144,702,722 - 144,712,453 (+)	NCBI		T2T-CHM13v2.0

Gsdmd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	75,733,990 - 75,739,257 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	75,734,176 - 75,739,257 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	75,862,144 - 75,867,408 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	75,862,327 - 75,867,408 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	75,692,769 - 75,697,834 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	75,689,594 - 75,694,659 (+)	NCBI		MGSCv36	mm8
Celera	15	77,363,199 - 77,368,383 (+)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	35.0	NCBI

Gsdmd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,423,209 - 109,427,771 (+)	NCBI		GRCr8
mRatBN7.2	7	107,542,489 - 107,547,051 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	107,542,083 - 107,547,055 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,281,502 - 109,286,064 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	111,505,178 - 111,509,740 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,451,127 - 111,455,689 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	116,889,147 - 116,894,134 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	116,889,572 - 116,894,134 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	116,781,947 - 116,786,875 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	113,832,420 - 113,837,007 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	113,847,420 - 113,871,239 (+)	NCBI
Celera	7	103,902,119 - 103,906,706 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Gsdmd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	2,265,753 - 2,271,655 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	2,265,759 - 2,270,569 (+)	NCBI	ChiLan1.0	ChiLan1.0

GSDMD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	161,039,881 - 161,046,166 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	136,557,568 - 136,563,849 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	140,311,042 - 140,316,084 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	143,321,800 - 143,331,455 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	143,326,319 - 143,331,455 (+)	Ensembl	panpan1.1		panPan2

Gsdmd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	1,141,008 - 1,145,358 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	8,567,091 - 8,571,467 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	8,567,085 - 8,571,448 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSDMD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	995,763 - 1,000,271 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	995,753 - 1,001,964 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	1,054,277 - 1,057,736 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSDMD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	137,778,290 - 137,783,542 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666039	2,110,335 - 2,115,465 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gsdmd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	13,187,687 - 13,192,736 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	13,187,810 - 13,192,843 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GSDMD
42 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005628031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005628032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022426846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022426847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022426848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022426849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022426850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038429475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038429487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038429493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038429498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038493440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038493441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038493442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038493443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038493444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038555738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038555739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038555740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038555741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038555742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038619640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038619642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038619643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038619644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038619645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038685250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038685251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038685252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038685253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038685254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000038192 ⟹ ENSCAFP00000033873

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	13	37,193,022 - 37,226,814 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000062254 ⟹ ENSCAFP00000044709

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	13	37,222,179 - 37,228,360 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027252 ⟹ ENSCAFP00845021440

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	13	37,693,447 - 37,699,135 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027296 ⟹ ENSCAFP00845021481

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	13	37,693,452 - 37,700,588 (+)	Ensembl

RefSeq Acc Id:

XM_022426849 ⟹ XP_022282557

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	13	37,222,273 - 37,226,912 (+)	NCBI
Dog10K_Boxer_Tasha	13	37,179,163 - 37,183,803 (+)	NCBI

Sequence:

show sequence

GGCGCCCCCCCCCCTCCCCGTTGCGGGCTGGGGTGTTTCCGGGAGTGGTTGCTGGCGTCAAGAG
GCCAAAGTTTCACTTTCGGTCCGGGCGCTGGCTACGCTTGCTTGGAGGCTCCTCAGCAGAGCAG
CGCCGCCCTGGTCTTGGGGCGGACTTGCTTCCCGTCGCGGGCCTGGAGCCGGGGGTGACAGTCA
CAGTGAGCTGCTCCCTGTGCCCAGAGCAATGGGATCTGCCTTTGAGGGAGTGATCAAGAGCGTG
ATCCGGGAGCTGGACCACAGAGGCAAGCTCATCCCCGTGGACAGTCTGCGGAGCTCCACCAGCT
TCCAGCCCTACTGCTTGCTGGCCAGGAAGCTCTCAAGACTGTGGTTCTGGAAACCCCGCTACAA
GTGCATCAACCTGTCCATCAGGGACATTCTGGAGCCTAATGACCCAGAACCAGATGTGAAATGT
GATGGCCCCTTCCACGTATGCGACTTCATGGACGGGCAGCTGCAGGGCTCTGTGGAGCTGGCAC
CCCCAGGACAGGTGCAGCTGGCAGGGGAGGCGACAGTGGCTGACAACCTCAGCACCTCGATGAA
CGTGTGTACACTGCGAGTGGTCCCCAACACCTGGGACACCATGCGCCAAGAGAGGCGCCTGCGT
CAGCCCCAGCACAAAGTCCTAGAGCAGCTGCGGAACTGTGGCAACGACATATTCGTGGTGACAG
AAGTGCTGCAGACACAGAAGGAGGTGACAGTCACCTGGATCTATAAGCAGGAGGGCTCCGGCCA
GTTTTCCCTGCCTGGAGCCCTGTCCCTCCAGGGCCAGGGCCATCTGAGGCGGAAGAAGACAGTC
ACCATCCCCTCAGGCAGCATCCTAGCATTCGAGGTGGCCCAGCTGGTTATCGGCCCTGACTGGG
ATGTCCTCCTCTTCCCGAACAAGAAGCAGAGGACCTTCAAGCAGTCCAAGAAAAATCACAAGCC
CACGAGCAGCGCAGGCTCCAAAATACAGTCGGACGGGTTTGGCGAGGACTTGGTGGCAGTCACA
GAAGACTTCCAGGGCCTGCTGGCAGAGGTGGGGACCCAGGCTGAGGGCCTGCGGGGCTTGTCCA
GGGGCCTGTGCGACCAGCTGCTGGCAGGCCTGGTGCGGGTGCTGCAGGAGGAGCCAGCCCTGCA
AACCCTGGAGGAGGCGCTGGAACAGGGCCTGTTCTGTGGGTGGGTGGCACCCCTGGAAGGTCCG
GTGGGCACTGTCCTCGAGTGCCTGGTGCATACCTCCAGAGCACTAGAAGAGCAACTTGCCAGAC
CCGTTCTCTACCTGGTGGACTTGCTGACTGGGCTGAGTGAAACCCAGCTCAAGCTGCTCACAAA
GGTCCTGGAGACAGGAGAGCTGTCCCGGCCCTTCAAGCTGGTGCAGAGCATTTTGGAGCAGAGC
ACCCCCTGGCAGGAGCGCAGGGCTGTGTCCCTGCCACAGGGGCTCCTGGAGGGCAGCTGGGATG
CAGAGGCACCTGCCTGGGTCTTGCTGGAGGAGTGTGGCCTCGAGCTGCAGGTGGACGACCCCCA
GGTGTGCTGGGAGCCAGAGGCCCGGGACCACACGTGTACACTCTATGCCTGTCTGGCACTGCTG
TTATGCCTGAGCGAGGACCCCTGTTAGGGCTGACCGGCTCTGCCCGCCAGCGTGCTGGGCAGCT
CTCCAGACGGCGTGGGGCTCATGCCCACCTGGCTGCCCGCACCGGGAAGGCGAGAGCCCCACCC
AGCCGTGCGGCCAGTGCATCCTGGGGTGGAGAGCTGGGGAAAGTCAGTAAATGTGATACACAAA
GGAAA

hide sequence

RefSeq Acc Id:

XM_038429475 ⟹ XP_038285403

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI

RefSeq Acc Id:

XM_038429487 ⟹ XP_038285415

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI

RefSeq Acc Id:

XM_038429493 ⟹ XP_038285421

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI

RefSeq Acc Id:

XM_038429498 ⟹ XP_038285426

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI

RefSeq Acc Id:

XM_038493440 ⟹ XP_038349368

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI

RefSeq Acc Id:

XM_038493441 ⟹ XP_038349369

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	13	37,368,840 - 37,373,478 (+)	NCBI

RefSeq Acc Id:

XM_038493442 ⟹ XP_038349370

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI

RefSeq Acc Id:

XM_038493443 ⟹ XP_038349371

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI

RefSeq Acc Id:

XM_038493444 ⟹ XP_038349372

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI

RefSeq Acc Id:

XM_038555738 ⟹ XP_038411666

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI

RefSeq Acc Id:

XM_038555739 ⟹ XP_038411667

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	13	37,966,969 - 37,971,607 (+)	NCBI

RefSeq Acc Id:

XM_038555740 ⟹ XP_038411668

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI

RefSeq Acc Id:

XM_038555741 ⟹ XP_038411669

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI

RefSeq Acc Id:

XM_038555742 ⟹ XP_038411670

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI

RefSeq Acc Id:

XM_038619640 ⟹ XP_038475568

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI

RefSeq Acc Id:

XM_038619642 ⟹ XP_038475570

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	13	37,485,799 - 37,490,434 (+)	NCBI

RefSeq Acc Id:

XM_038619643 ⟹ XP_038475571

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI

RefSeq Acc Id:

XM_038619644 ⟹ XP_038475572

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI

RefSeq Acc Id:

XM_038619645 ⟹ XP_038475573

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI

RefSeq Acc Id:

XM_038685250 ⟹ XP_038541178

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI

RefSeq Acc Id:

XM_038685251 ⟹ XP_038541179

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	13	37,694,499 - 37,699,140 (+)	NCBI

RefSeq Acc Id:

XM_038685252 ⟹ XP_038541180

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI

RefSeq Acc Id:

XM_038685253 ⟹ XP_038541181

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI

RefSeq Acc Id:

XM_038685254 ⟹ XP_038541182

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_022282557	(Get FASTA)	NCBI Sequence Viewer
	XP_038285403	(Get FASTA)	NCBI Sequence Viewer
	XP_038285415	(Get FASTA)	NCBI Sequence Viewer
	XP_038285421	(Get FASTA)	NCBI Sequence Viewer
	XP_038285426	(Get FASTA)	NCBI Sequence Viewer
	XP_038349368	(Get FASTA)	NCBI Sequence Viewer
	XP_038349369	(Get FASTA)	NCBI Sequence Viewer
	XP_038349370	(Get FASTA)	NCBI Sequence Viewer
	XP_038349371	(Get FASTA)	NCBI Sequence Viewer
	XP_038349372	(Get FASTA)	NCBI Sequence Viewer
	XP_038411666	(Get FASTA)	NCBI Sequence Viewer
	XP_038411667	(Get FASTA)	NCBI Sequence Viewer
	XP_038411668	(Get FASTA)	NCBI Sequence Viewer
	XP_038411669	(Get FASTA)	NCBI Sequence Viewer
	XP_038411670	(Get FASTA)	NCBI Sequence Viewer
	XP_038475568	(Get FASTA)	NCBI Sequence Viewer
	XP_038475570	(Get FASTA)	NCBI Sequence Viewer
	XP_038475571	(Get FASTA)	NCBI Sequence Viewer
	XP_038475572	(Get FASTA)	NCBI Sequence Viewer
	XP_038475573	(Get FASTA)	NCBI Sequence Viewer
	XP_038541178	(Get FASTA)	NCBI Sequence Viewer
	XP_038541179	(Get FASTA)	NCBI Sequence Viewer
	XP_038541180	(Get FASTA)	NCBI Sequence Viewer
	XP_038541181	(Get FASTA)	NCBI Sequence Viewer
	XP_038541182	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000033873.4
	ENSCAFP00000044709.2
	ENSCAFP00000068357.1
	ENSCAFP00000072642.1
	ENSCAFP00030038464.1
	ENSCAFP00040018674.1
	ENSCAFP00845021440
	ENSCAFP00845021440.1
	ENSCAFP00845021481
	ENSCAFP00845021481.1

RefSeq Acc Id:

XP_022282557 ⟸ XM_022426849

- UniProtKB:

A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSAFEGVIKSVIRELDHRGKLIPVDSLRSSTSFQPYCLLARKLSRLWFWKPRYKCINLSIRDI
LEPNDPEPDVKCDGPFHVCDFMDGQLQGSVELAPPGQVQLAGEATVADNLSTSMNVCTLRVVPN
TWDTMRQERRLRQPQHKVLEQLRNCGNDIFVVTEVLQTQKEVTVTWIYKQEGSGQFSLPGALSL
QGQGHLRRKKTVTIPSGSILAFEVAQLVIGPDWDVLLFPNKKQRTFKQSKKNHKPTSSAGSKIQ
SDGFGEDLVAVTEDFQGLLAEVGTQAEGLRGLSRGLCDQLLAGLVRVLQEEPALQTLEEALEQG
LFCGWVAPLEGPVGTVLECLVHTSRALEEQLARPVLYLVDLLTGLSETQLKLLTKVLETGELSR
PFKLVQSILEQSTPWQERRAVSLPQGLLEGSWDAEAPAWVLLEECGLELQVDDPQVCWEPEARD
HTCTLYACLALLLCLSEDPC

hide sequence

Ensembl Acc Id:

ENSCAFP00000033873 ⟸ ENSCAFT00000038192

Ensembl Acc Id:

ENSCAFP00000044709 ⟸ ENSCAFT00000062254

RefSeq Acc Id:

XP_038349370 ⟸ XM_038493442

RefSeq Acc Id:

XP_038349371 ⟸ XM_038493443

RefSeq Acc Id:

XP_038349368 ⟸ XM_038493440

RefSeq Acc Id:

XP_038349372 ⟸ XM_038493444

RefSeq Acc Id:

XP_038349369 ⟸ XM_038493441

RefSeq Acc Id:

XP_038475571 ⟸ XM_038619643

RefSeq Acc Id:

XP_038475572 ⟸ XM_038619644

RefSeq Acc Id:

XP_038475568 ⟸ XM_038619640

RefSeq Acc Id:

XP_038475573 ⟸ XM_038619645

RefSeq Acc Id:

XP_038475570 ⟸ XM_038619642

RefSeq Acc Id:	XP_038541180 ⟸ XM_038685252
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038541181 ⟸ XM_038685253
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038541178 ⟸ XM_038685250
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038541182 ⟸ XM_038685254
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038541179 ⟸ XM_038685251
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038285415 ⟸ XM_038429487
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038285421 ⟸ XM_038429493
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038285403 ⟸ XM_038429475
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038285426 ⟸ XM_038429498
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038411668 ⟸ XM_038555740
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038411669 ⟸ XM_038555741
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038411666 ⟸ XM_038555738
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038411670 ⟸ XM_038555742
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038411667 ⟸ XM_038555739
- UniProtKB:	A0A8C0L4Q4 (UniProtKB/TrEMBL), A0A8C0SB41 (UniProtKB/TrEMBL), A0A8I3NWY6 (UniProtKB/TrEMBL), A0A8P0PNE4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845021440 ⟸ ENSCAFT00845027252

Ensembl Acc Id:

ENSCAFP00845021481 ⟸ ENSCAFT00845027296

Protein Domains

Gasdermin pore forming Gasdermin PUB

Promoters

RGD ID:

13685618

Promoter ID:

EPDNEW_C3687

Type:

initiation region

Name:

GSDMD_1

Description:

gasdermin D

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	13	37,222,348 - 37,222,408	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001301	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030023984	UniProtKB/TrEMBL
	ENSCAFG00040011655	UniProtKB/TrEMBL
	ENSCAFG00845015279	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000038192.4	UniProtKB/TrEMBL
	ENSCAFT00000062254.2	UniProtKB/TrEMBL
	ENSCAFT00000104745.1	UniProtKB/TrEMBL
	ENSCAFT00000109991.1	UniProtKB/TrEMBL
	ENSCAFT00030044071.1	UniProtKB/TrEMBL
	ENSCAFT00040021511.1	UniProtKB/TrEMBL
	ENSCAFT00845027252	ENTREZGENE
	ENSCAFT00845027252.1	UniProtKB/TrEMBL
	ENSCAFT00845027296	ENTREZGENE
	ENSCAFT00845027296.1	UniProtKB/TrEMBL
InterPro	Gasdermin_pore	UniProtKB/TrEMBL
	Gasdermin_PUB	UniProtKB/TrEMBL
NCBI Gene	GSDMD	ENTREZGENE
PANTHER	GASDERMIN-D	UniProtKB/TrEMBL
	PTHR16399	UniProtKB/TrEMBL
Pfam	Gasdermin	UniProtKB/TrEMBL
	Gasdermin_C	UniProtKB/TrEMBL
UniProt	A0A8C0L4Q4	ENTREZGENE
	A0A8C0PQH0_CANLF	UniProtKB/TrEMBL
	A0A8C0SB41	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NWY6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S1E2_CANLF	UniProtKB/TrEMBL
	A0A8P0PNE4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SXZ9_CANLF	UniProtKB/TrEMBL
	A0A8P0TKC7_CANLF	UniProtKB/TrEMBL
UniProt Secondary	A0A8P0NMS2	UniProtKB/TrEMBL
VGNC ID	VGNC:41526	ENTREZGENE

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar