NELFB (negative elongation factor complex member B) - Rat Genome Database

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Gene: NELFB (negative elongation factor complex member B) Canis lupus familiaris
Analyze
Symbol: NELFB
Name: negative elongation factor complex member B
RGD ID: 12378040
Description: INVOLVED IN cell population proliferation (inferred); negative regulation of DNA-templated transcription (inferred); negative regulation of stem cell differentiation (inferred); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: COBRA1; cofactor of BRCA1; negative elongation factor B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,411,725 - 48,425,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,408,005 - 48,423,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,598,208 - 47,608,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,273,065 - 49,283,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,206,548 - 49,287,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,049,494 - 48,060,162 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,348,232 - 48,358,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,395,161 - 48,405,870 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
NELF complex  (IBA)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NELFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,411,725 - 48,425,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,408,005 - 48,423,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,598,208 - 47,608,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,273,065 - 49,283,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,206,548 - 49,287,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,049,494 - 48,060,162 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,348,232 - 48,358,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,395,161 - 48,405,870 (-)NCBIUU_Cfam_GSD_1.0
NELFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,255,327 - 137,273,542 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,255,327 - 137,273,542 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,149,779 - 140,167,994 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,269,768 - 139,287,815 (+)NCBINCBI36Build 36hg18NCBI36
Celera9110,665,618 - 110,683,794 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,609,072 - 109,627,292 (+)NCBIHuRef
CHM1_19140,298,493 - 140,316,577 (+)NCBICHM1_1
T2T-CHM13v2.09149,492,996 - 149,511,192 (+)NCBIT2T-CHM13v2.0
Nelfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,089,724 - 25,101,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,089,724 - 25,101,501 (-)EnsemblGRCm39 Ensembl
GRCm38225,199,712 - 25,211,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,199,712 - 25,211,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,055,232 - 25,067,009 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,021,726 - 25,033,390 (-)NCBIMGSCv36mm8
Celera224,927,483 - 24,939,264 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.06NCBI
Nelfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,409,045 - 28,425,564 (-)NCBIGRCr8
mRatBN7.238,010,883 - 8,027,403 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,010,888 - 8,027,403 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,115,610 - 11,132,086 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,701,839 - 19,718,315 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,891,682 - 17,908,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,414,448 - 2,431,148 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,414,451 - 2,431,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,395,734 - 2,412,431 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,360,222 - 3,376,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,360,218 - 3,376,563 (-)NCBI
Celera32,837,727 - 2,854,117 (-)NCBICelera
Cytogenetic Map3p13NCBI
Nelfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,248,190 - 5,262,044 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,248,190 - 5,261,018 (+)NCBIChiLan1.0ChiLan1.0
NELFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,126,248 - 2,144,680 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,128,581 - 2,147,028 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,314,535 - 108,333,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,283,264 - 137,301,751 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,278,964 - 137,301,751 (+)Ensemblpanpan1.1panPan2
Nelfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,636,347 - 202,648,327 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669726,658 - 738,848 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669726,731 - 738,714 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21314,117,252 - 314,125,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112914,384 - 933,921 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660584,373,307 - 4,392,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nelfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760692,735 - 705,328 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760692,735 - 703,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NELFB
130 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00000030924   ⟹   ENSCAFP00000028758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,408,005 - 48,422,944 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000030929   ⟹   ENSCAFP00000028763
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,412,505 - 48,423,308 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040463   ⟹   ENSCAFP00845031681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl949,206,548 - 49,287,069 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040587   ⟹   ENSCAFP00845031770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl949,235,325 - 49,287,069 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040711   ⟹   ENSCAFP00845031867
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl949,273,065 - 49,283,854 (-)Ensembl
RefSeq Acc Id: XM_038486786   ⟹   XP_038342714
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1948,049,494 - 48,060,162 (-)NCBI
RefSeq Acc Id: XM_038548653   ⟹   XP_038404581
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0948,395,161 - 48,405,870 (-)NCBI
RefSeq Acc Id: XM_038612591   ⟹   XP_038468519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0948,348,232 - 48,358,986 (-)NCBI
RefSeq Acc Id: XM_038677874   ⟹   XP_038533802
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,273,065 - 49,283,756 (-)NCBI
RefSeq Acc Id: XM_548351   ⟹   XP_548351
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,411,725 - 48,425,044 (-)NCBI
Dog10K_Boxer_Tasha947,598,208 - 47,608,900 (-)NCBI
Sequence:
RefSeq Acc Id: XP_548351   ⟸   XM_548351
- UniProtKB: A0A8C0QUI5 (UniProtKB/TrEMBL),   A0A8C0S7U9 (UniProtKB/TrEMBL),   A0A8I3S3F0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000028763   ⟸   ENSCAFT00000030929
Ensembl Acc Id: ENSCAFP00000028758   ⟸   ENSCAFT00000030924
RefSeq Acc Id: XP_038342714   ⟸   XM_038486786
RefSeq Acc Id: XP_038468519   ⟸   XM_038612591
RefSeq Acc Id: XP_038533802   ⟸   XM_038677874
- UniProtKB: A0A8C0QUI5 (UniProtKB/TrEMBL),   A0A8C0S7U9 (UniProtKB/TrEMBL),   A0A8I3S3F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404581   ⟸   XM_038548653
- UniProtKB: A0A8C0QUI5 (UniProtKB/TrEMBL),   A0A8C0S7U9 (UniProtKB/TrEMBL),   A0A8I3S3F0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845031867   ⟸   ENSCAFT00845040711
Ensembl Acc Id: ENSCAFP00845031681   ⟸   ENSCAFT00845040463
Ensembl Acc Id: ENSCAFP00845031770   ⟸   ENSCAFT00845040587

Promoters
RGD ID:13684738
Promoter ID:EPDNEW_C2807
Type:initiation region
Name:NELFB_1
Description:negative elongation factor complex member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,422,673 - 48,422,733EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019450 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005484 UniProtKB/TrEMBL
  ENSCAFG00040010402 UniProtKB/TrEMBL
  ENSCAFG00845022933 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030924.3 UniProtKB/TrEMBL
  ENSCAFT00000030929.5 UniProtKB/TrEMBL
  ENSCAFT00000109369.1 UniProtKB/TrEMBL
  ENSCAFT00030010047.1 UniProtKB/TrEMBL
  ENSCAFT00030010112.1 UniProtKB/TrEMBL
  ENSCAFT00040019359.1 UniProtKB/TrEMBL
  ENSCAFT00040019541.1 UniProtKB/TrEMBL
  ENSCAFT00845040463.1 UniProtKB/TrEMBL
  ENSCAFT00845040587.1 UniProtKB/TrEMBL
  ENSCAFT00845040711 ENTREZGENE
  ENSCAFT00845040711.1 UniProtKB/TrEMBL
InterPro COBRA1 UniProtKB/TrEMBL
NCBI Gene NELFB ENTREZGENE
PANTHER NEGATIVE ELONGATION FACTOR B UniProtKB/TrEMBL
  PTHR13503 UniProtKB/TrEMBL
Pfam COBRA1 UniProtKB/TrEMBL
UniProt A0A8C0QUI5 ENTREZGENE
  A0A8C0RDA0_CANLF UniProtKB/TrEMBL
  A0A8C0S7U9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PDG3_CANLF UniProtKB/TrEMBL
  A0A8I3PHJ8_CANLF UniProtKB/TrEMBL
  A0A8I3S3F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SNC6_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0SNU7 UniProtKB/TrEMBL
VGNC ID VGNC:43737 ENTREZGENE