CLCN2 (chloride voltage-gated channel 2) - Rat Genome Database

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Gene: CLCN2 (chloride voltage-gated channel 2) Canis lupus familiaris
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Symbol: CLCN2
Name: chloride voltage-gated channel 2
RGD ID: 12372757
Description: ENCODES a protein that exhibits voltage-gated chloride channel activity (ortholog); volume-sensitive chloride channel activity (ortholog); INVOLVED IN acinar cell differentiation (ortholog); cell differentiation involved in salivary gland development (ortholog); cellular hypotonic response (ortholog); ASSOCIATED WITH 3-methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon initial segment (ortholog); dendrite (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chloride channel 2; chloride channel protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,224,136 - 17,238,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,309,705 - 21,324,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,131,619 - 17,146,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,168,519 - 17,183,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,164,603 - 17,179,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,393,559 - 17,408,134 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CLCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,224,136 - 17,238,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,309,705 - 21,324,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,131,619 - 17,146,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,168,519 - 17,183,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,164,603 - 17,179,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,393,559 - 17,408,134 (-)NCBIUU_Cfam_GSD_1.0
CLCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,346,185 - 184,361,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,346,185 - 184,361,650 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,063,973 - 184,079,393 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,547,034 - 185,562,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,547,095 - 185,561,969NCBI
Celera3182,504,875 - 182,520,290 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,470,404 - 181,485,871 (-)NCBIHuRef
CHM1_13184,028,432 - 184,043,898 (-)NCBICHM1_1
T2T-CHM13v2.03187,155,451 - 187,170,873 (-)NCBIT2T-CHM13v2.0
Clcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,521,185 - 20,536,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,521,714 - 20,536,496 (-)EnsemblGRCm39 Ensembl
GRCm381620,702,435 - 20,717,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,702,964 - 20,717,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,703,039 - 20,716,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,616,509 - 20,629,657 (-)NCBIMGSCv36mm8
Celera1621,268,322 - 21,281,991 (-)NCBICelera
Cytogenetic Map16A3- B1NCBI
cM Map1612.5NCBI
Clcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
Clcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBIChiLan1.0ChiLan1.0
CLCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,865,627 - 189,881,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,862,489 - 189,881,049 (-)Ensemblpanpan1.1panPan2
Clcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,433,596 - 119,447,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,525,601 - 5,539,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,525,461 - 5,539,351 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,234,736 - 122,249,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,234,731 - 122,249,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,674,508 - 131,689,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,057,687 - 5,073,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,057,900 - 5,073,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,835,604 - 13,851,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,228,189 - 72,244,332 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,228,912 - 72,242,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CLCN2
131 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000020332   ⟹   ENSCAFP00000018865
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3417,224,208 - 17,239,621 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000069672   ⟹   ENSCAFP00000064086
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845049951   ⟹   ENSCAFP00845039171
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)Ensembl
RefSeq Acc Id: XM_005639775   ⟹   XP_005639832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13417,224,136 - 17,238,751 (-)NCBI
Dog10K_Boxer_Tasha3421,309,705 - 21,324,279 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445731   ⟹   XP_038301659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03417,131,619 - 17,146,201 (-)NCBI
RefSeq Acc Id: XM_038519923   ⟹   XP_038375851
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13417,168,519 - 17,183,093 (-)NCBI
RefSeq Acc Id: XM_038583558   ⟹   XP_038439486
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03417,393,559 - 17,408,133 (-)NCBI
RefSeq Acc Id: XM_038647965   ⟹   XP_038503893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03417,164,603 - 17,179,166 (-)NCBI
RefSeq Acc Id: XR_002622700
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13417,224,890 - 17,238,755 (-)NCBI
Dog10K_Boxer_Tasha3421,310,452 - 21,324,280 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005306836
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03417,132,366 - 17,146,202 (-)NCBI
RefSeq Acc Id: XR_005349802
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13417,169,266 - 17,183,094 (-)NCBI
RefSeq Acc Id: XR_005383798
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03417,394,306 - 17,408,134 (-)NCBI
RefSeq Acc Id: XR_005417471
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03417,165,350 - 17,179,167 (-)NCBI
RefSeq Acc Id: XP_005639832   ⟸   XM_005639775
- UniProtKB: A0A8C0RGC4 (UniProtKB/TrEMBL),   A0A8I3Q0B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000064086   ⟸   ENSCAFT00000069672
Ensembl Acc Id: ENSCAFP00000018865   ⟸   ENSCAFT00000020332
RefSeq Acc Id: XP_038375851   ⟸   XM_038519923
RefSeq Acc Id: XP_038503893   ⟸   XM_038647965
RefSeq Acc Id: XP_038301659   ⟸   XM_038445731
- UniProtKB: A0A8C0RGC4 (UniProtKB/TrEMBL),   A0A8I3Q0B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439486   ⟸   XM_038583558
- UniProtKB: A0A8C0RGC4 (UniProtKB/TrEMBL),   A0A8I3Q0B9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845039171   ⟸   ENSCAFT00845049951


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012764 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009262 UniProtKB/TrEMBL
  ENSCAFG00040024893 UniProtKB/TrEMBL
  ENSCAFG00845028147 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020332.6 UniProtKB/TrEMBL
  ENSCAFT00030017240.1 UniProtKB/TrEMBL
  ENSCAFT00040046377.1 UniProtKB/TrEMBL
  ENSCAFT00845049951 ENTREZGENE
  ENSCAFT00845049951.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.580.10 UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/TrEMBL
InterPro CBS_dom_sf UniProtKB/TrEMBL
  Cl-channel-2 UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/TrEMBL
  Cl_channel_volt-gated UniProtKB/TrEMBL
KEGG Report cfa:488106 UniProtKB/TrEMBL
NCBI Gene CLCN2 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
Pfam Voltage_CLC UniProtKB/TrEMBL
PRINTS CLCHANNEL UniProtKB/TrEMBL
  CLCHANNEL2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/TrEMBL
  SSF81340 UniProtKB/TrEMBL
UniProt A0A8C0RGC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q0B9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39302 ENTREZGENE