TBXT (T-box transcription factor T) - Rat Genome Database

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Gene: TBXT (T-box transcription factor T) Canis lupus familiaris
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Symbol: TBXT
Name: T-box transcription factor T
RGD ID: 12372074
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN anatomical structure morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); ASSOCIATED WITH short tail; ASSOCIATED WITH autosomal recessive intellectual developmental disorder 40 (ortholog); chordoma (ortholog); neural tube defect (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: brachyury; brachyury protein; protein T; T; T brachyury protein; T brachyury transcription factor; T, brachyury homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,183,495 - 54,192,331 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,183,153 - 54,192,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha154,970,966 - 54,979,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,360,266 - 54,369,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,360,928 - 54,369,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,257,349 - 54,266,189 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,107,519 - 54,116,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,733,858 - 54,742,687 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IEA)
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
short tail  (IAGP)
References
Additional References at PubMed
PMID:11252170   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TBXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,183,495 - 54,192,331 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,183,153 - 54,192,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha154,970,966 - 54,979,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,360,266 - 54,369,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,360,928 - 54,369,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,257,349 - 54,266,189 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,107,519 - 54,116,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,733,858 - 54,742,687 (-)NCBIUU_Cfam_GSD_1.0
TBXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,157,656 - 166,168,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,157,656 - 166,168,700 (-)EnsemblGRCh38hg38GRCh38
GRCh376166,571,144 - 166,582,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,491,076 - 166,502,121 (-)NCBINCBI36Build 36hg18NCBI36
Build 346166,541,496 - 166,552,542NCBI
Celera6167,310,712 - 167,321,757 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,037,863 - 164,048,876 (-)NCBIHuRef
CHM1_16166,835,290 - 166,846,303 (-)NCBICHM1_1
T2T-CHM13v2.06167,527,458 - 167,538,457 (-)NCBIT2T-CHM13v2.0
T
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,653,255 - 8,661,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,653,255 - 8,661,328 (+)EnsemblGRCm39 Ensembl
GRCm38178,434,423 - 8,442,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,434,423 - 8,442,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,627,288 - 8,635,361 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36178,272,597 - 8,280,670 (+)NCBIMGSCv36mm8
Celera178,480,245 - 8,488,318 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.92NCBI
Tbxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,845,674 - 54,859,340 (-)NCBIGRCr8
mRatBN7.2152,298,104 - 52,309,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,298,099 - 52,305,864 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,999,608 - 53,007,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0158,991,427 - 58,999,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,075,196 - 53,082,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,887,067 - 52,900,691 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,887,067 - 52,894,832 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,139,554 - 54,147,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,937,223 - 46,944,988 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,940,188 - 46,947,933 (-)NCBI
Celera148,061,384 - 48,069,149 (-)NCBICelera
Cytogenetic Map1q12NCBI
Tbxt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543915,676,095 - 15,683,554 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543915,675,680 - 15,683,542 (+)NCBIChiLan1.0ChiLan1.0
TBXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25186,353,564 - 186,363,413 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16184,249,368 - 184,259,217 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,112,117 - 164,122,253 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16169,095,723 - 169,106,595 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6169,095,723 - 169,106,595 (-)Ensemblpanpan1.1panPan2
Tbxt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,774,775 - 148,782,886 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,027,359 - 16,035,041 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,027,359 - 16,035,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,717,165 - 2,725,601 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112,717,165 - 2,725,561 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,857,228 - 3,861,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBXT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11393,854,086 - 93,864,910 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1393,855,534 - 93,864,507 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604065,656,160 - 65,666,958 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbxt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478513,058,444 - 13,066,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478513,058,520 - 13,066,607 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TBXT
148 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
integumental system
reproductive system
respiratory system
2 1 1 2 6 1

Sequence


Ensembl Acc Id: ENSCAFT00000001265   ⟹   ENSCAFP00000001157
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl154,183,495 - 54,192,352 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000080786   ⟹   ENSCAFP00000050704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl154,183,153 - 54,192,352 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845008388   ⟹   ENSCAFP00845006600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl154,360,928 - 54,369,833 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845008391   ⟹   ENSCAFP00845006603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl154,360,928 - 54,369,833 (-)Ensembl
RefSeq Acc Id: NM_001003092   ⟹   NP_001003092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1154,183,495 - 54,192,331 (-)NCBI
Dog10K_Boxer_Tasha154,970,966 - 54,979,790 (-)NCBI
ROS_Cfam_1.0154,360,928 - 54,369,833 (-)NCBI
UMICH_Zoey_3.1154,257,349 - 54,266,189 (-)NCBI
UNSW_CanFamBas_1.0154,107,519 - 54,116,264 (-)NCBI
UU_Cfam_GSD_1.0154,733,858 - 54,742,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038653377   ⟹   XP_038509305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0154,360,266 - 54,369,833 (-)NCBI
RefSeq Acc Id: NP_001003092   ⟸   NM_001003092
- UniProtKB: Q9GL27 (UniProtKB/Swiss-Prot),   A0A8C0L3P5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001157   ⟸   ENSCAFT00000001265
Ensembl Acc Id: ENSCAFP00000050704   ⟸   ENSCAFT00000080786
RefSeq Acc Id: XP_038509305   ⟸   XM_038653377
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RFC1 (UniProtKB/TrEMBL),   A0A8I3MTQ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845006600   ⟸   ENSCAFT00845008388
Ensembl Acc Id: ENSCAFP00845006603   ⟸   ENSCAFT00845008391
Protein Domains
T-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000807 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008046 UniProtKB/TrEMBL
  ENSCAFG00040001375 UniProtKB/TrEMBL
  ENSCAFG00845004679 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001265.5 UniProtKB/TrEMBL
  ENSCAFT00000080786.2 UniProtKB/TrEMBL
  ENSCAFT00030014830.1 UniProtKB/TrEMBL
  ENSCAFT00030014918.1 UniProtKB/TrEMBL
  ENSCAFT00040002612.1 UniProtKB/TrEMBL
  ENSCAFT00040002632.1 UniProtKB/TrEMBL
  ENSCAFT00845008388 ENTREZGENE
  ENSCAFT00845008388.1 UniProtKB/TrEMBL
  ENSCAFT00845008391 ENTREZGENE
  ENSCAFT00845008391.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_Brachyury UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403653 UniProtKB/Swiss-Prot
NCBI Gene T ENTREZGENE
PANTHER PTHR11267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR T UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BRACHYURY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0L3P5 ENTREZGENE
  A0A8C0MTP6_CANLF UniProtKB/TrEMBL
  A0A8C0RFC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MTQ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTP5_CANLF UniProtKB/TrEMBL
  Q9GL27 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:47058 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-26 TBXT  T-box transcription factor T  T brachyury transcription factor  Symbol and/or name change 5135510 APPROVED