DKK3 (dickkopf WNT signaling pathway inhibitor 3) - Rat Genome Database

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Gene: DKK3 (dickkopf WNT signaling pathway inhibitor 3) Canis lupus familiaris
Analyze
Symbol: DKK3
Name: dickkopf WNT signaling pathway inhibitor 3
RGD ID: 12370716
Description: INVOLVED IN adrenal gland development (inferred); negative regulation of aldosterone biosynthetic process (inferred); negative regulation of canonical Wnt signaling pathway (inferred); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); intellectual disability (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dickkopf 3 homolog; dickkopf homolog 3; dickkopf-related protein 3; REIC/Dkk-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:23732075   PMID:28599655   PMID:30032202  


Genomics

Comparative Map Data
DKK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBIUU_Cfam_GSD_1.0
DKK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,963,036 - 12,009,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
T2T-CHM13v2.01112,054,919 - 12,101,206 (-)NCBIT2T-CHM13v2.0
Dkk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397111,715,226 - 111,758,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7111,715,224 - 111,758,264 (-)EnsemblGRCm39 Ensembl
GRCm387112,116,019 - 112,159,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,116,017 - 112,159,057 (-)EnsemblGRCm38mm10GRCm38
MGSCv377119,259,533 - 119,302,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367111,907,200 - 111,950,238 (-)NCBIMGSCv36mm8
Celera7112,091,357 - 112,134,444 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map758.74NCBI
Dkk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,672,834 - 175,715,867 (-)NCBIGRCr8
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,573,298 - 174,615,607 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,759,295 - 181,801,602 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01174,459,245 - 174,501,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
Dkk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,456,770 - 27,508,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541427,466,636 - 27,507,186 (-)NCBIChiLan1.0ChiLan1.0
DKK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2914,409,852 - 14,456,349 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,372,466 - 14,418,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,131,306 - 12,177,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11111,824,955 - 11,871,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,824,955 - 11,871,139 (-)Ensemblpanpan1.1panPan2
Dkk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494750,394,918 - 50,443,027 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365286,429,973 - 6,477,218 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365286,428,824 - 6,477,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,192 - 47,444,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,823,415 - 52,868,804 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl152,824,176 - 52,868,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038150,424,876 - 150,470,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247664,041,816 - 4,085,209 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247664,042,307 - 4,085,613 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DKK3
803 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000012527   ⟹   ENSCAFP00000011598
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845030630   ⟹   ENSCAFP00845024032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,171 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845030743   ⟹   ENSCAFP00845024110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2135,907,935 - 35,950,691 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845030795   ⟹   ENSCAFP00845024145
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2135,907,935 - 35,950,171 (-)Ensembl
RefSeq Acc Id: NM_001284475   ⟹   NP_001271404
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,033,878 - 35,074,664 (-)NCBI
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBI
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBI
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBI
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBI
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001271404   ⟸   NM_001284475
- Peptide Label: precursor
- UniProtKB: A0A8C0T1J9 (UniProtKB/TrEMBL),   A0A8I3P0C0 (UniProtKB/TrEMBL),   W0RY37 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000011598   ⟸   ENSCAFT00000012527
Ensembl Acc Id: ENSCAFP00845024032   ⟸   ENSCAFT00845030630
Ensembl Acc Id: ENSCAFP00845024110   ⟸   ENSCAFT00845030743
Ensembl Acc Id: ENSCAFP00845024145   ⟸   ENSCAFT00845030795
Promoters
RGD ID:13687251
Promoter ID:EPDNEW_C5319
Type:multiple initiation site
Name:DKK3_1
Description:Canis lupus familiaris dickkopf WNT signaling pathway inhibitor3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,074,705 - 35,074,765EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007845 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030026085 UniProtKB/TrEMBL
  ENSCAFG00040017516 UniProtKB/TrEMBL
  ENSCAFG00845017299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012527.7 UniProtKB/TrEMBL
  ENSCAFT00000104194.1 UniProtKB/TrEMBL
  ENSCAFT00000109784.1 UniProtKB/TrEMBL
  ENSCAFT00030048249.1 UniProtKB/TrEMBL
  ENSCAFT00030048256.1 UniProtKB/TrEMBL
  ENSCAFT00030048263.1 UniProtKB/TrEMBL
  ENSCAFT00040032362.1 UniProtKB/TrEMBL
  ENSCAFT00845030630.1 UniProtKB/TrEMBL
  ENSCAFT00845030743.1 UniProtKB/TrEMBL
  ENSCAFT00845030795 ENTREZGENE
  ENSCAFT00845030795.1 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk3_Cys2 UniProtKB/TrEMBL
  Dkk3_N UniProtKB/TrEMBL
KEGG Report cfa:476857 UniProtKB/TrEMBL
NCBI Gene DKK3 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 3 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
UniProt A0A8C0PI64_CANLF UniProtKB/TrEMBL
  A0A8C0PZE0_CANLF UniProtKB/TrEMBL
  A0A8C0T1J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P0C0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S2K3_CANLF UniProtKB/TrEMBL
  A0A8P0NAE2_CANLF UniProtKB/TrEMBL
  A0A8P0PQ44_CANLF UniProtKB/TrEMBL
  A0A8P0TPK0_CANLF UniProtKB/TrEMBL
  W0RY37 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39971 ENTREZGENE