PAWR (pro-apoptotic WT1 regulator) - Rat Genome Database

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Gene: PAWR (pro-apoptotic WT1 regulator) Canis lupus familiaris
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Symbol: PAWR
Name: pro-apoptotic WT1 regulator
RGD ID: 12362063
Description: ENCODES a protein that exhibits actin binding (ortholog); protein kinase C binding (ortholog); protein phosphatase 1 binding (ortholog); INVOLVED IN actin filament bundle assembly (ortholog); calcium ion import across plasma membrane (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN ceramide signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN actin filament (ortholog); axon (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11522,114,014 - 22,159,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1522,543,122 - 22,644,822 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01522,466,453 - 22,568,184 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1522,468,188 - 22,568,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11522,054,871 - 22,156,503 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01522,115,634 - 22,217,474 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01522,355,750 - 22,457,672 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament bundle assembly  (ISO)
apoptotic process  (IEA)
apoptotic signaling pathway  (IEA)
calcium ion import across plasma membrane  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to vitamin E  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
negative regulation of B cell proliferation  (IEA)
negative regulation of calcium ion import  (ISO)
negative regulation of fibroblast proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of T cell proliferation  (IEA)
negative regulation of T cell receptor signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of action potential  (ISO)
positive regulation of amyloid precursor protein biosynthetic process  (IEA)
positive regulation of apoptotic process  (IBA,ISO)
positive regulation of cellular senescence  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of hindgut contraction  (ISO)
positive regulation of hydrogen peroxide-mediated programmed cell death  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of leukocyte tethering or rolling  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuronal action potential  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of relaxation of smooth muscle  (ISO)
response to estradiol  (ISO)
response to iron(II) ion  (ISO)
response to lipopolysaccharide  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PAWR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11522,114,014 - 22,159,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1522,543,122 - 22,644,822 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01522,466,453 - 22,568,184 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1522,468,188 - 22,568,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11522,054,871 - 22,156,503 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01522,115,634 - 22,217,474 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01522,355,750 - 22,457,672 (-)NCBIUU_Cfam_GSD_1.0
PAWR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381279,584,879 - 79,690,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1279,574,979 - 79,690,964 (-)EnsemblGRCh38hg38GRCh38
GRCh371279,978,659 - 80,084,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,509,876 - 78,608,921 (-)NCBINCBI36Build 36hg18NCBI36
Build 341278,488,214 - 78,587,258NCBI
Celera1279,652,459 - 79,751,312 (-)NCBICelera
Cytogenetic Map12q21.2NCBI
HuRef1277,042,009 - 77,141,117 (-)NCBIHuRef
CHM1_11279,952,168 - 80,051,122 (-)NCBICHM1_1
T2T-CHM13v2.01279,563,553 - 79,669,620 (-)NCBIT2T-CHM13v2.0
Pawr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910108,168,050 - 108,250,708 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10108,167,982 - 108,250,101 (+)EnsemblGRCm39 Ensembl
GRCm3810108,332,189 - 108,414,391 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10108,332,121 - 108,414,240 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710107,769,245 - 107,851,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610107,736,299 - 107,817,863 (+)NCBIMGSCv36mm8
Celera10110,266,638 - 110,348,648 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1056.43NCBI
Pawr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,531,480 - 45,611,492 (+)NCBIGRCr8
mRatBN7.2743,645,028 - 43,725,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,645,084 - 43,725,028 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx745,554,243 - 45,635,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,757,364 - 47,838,790 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,535,105 - 47,616,535 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0751,273,764 - 51,353,700 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl751,273,771 - 51,353,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0751,286,663 - 51,366,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4747,040,162 - 47,119,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1747,060,432 - 47,139,881 (+)NCBI
Celera740,512,247 - 40,591,588 (+)NCBICelera
Cytogenetic Map7q21NCBI
Pawr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540518,434,711 - 18,540,710 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540518,434,711 - 18,540,710 (-)NCBIChiLan1.0ChiLan1.0
PAWR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21087,634,172 - 87,743,476 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11287,630,560 - 87,739,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01277,114,282 - 77,224,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11279,964,693 - 80,071,088 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1279,969,517 - 80,070,796 (-)Ensemblpanpan1.1panPan2
Pawr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494538,166,185 - 38,266,605 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936698650,953 - 747,057 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936698650,225 - 746,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAWR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5101,693,246 - 101,797,838 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15101,693,145 - 101,797,842 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25106,705,487 - 106,742,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAWR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11175,132,547 - 75,219,633 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1175,133,186 - 75,219,072 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037170,232,946 - 170,321,286 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pawr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475018,562,221 - 18,705,540 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475018,562,270 - 18,710,397 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PAWR
506 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845013686   ⟹   ENSCAFP00845010624
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1522,468,188 - 22,568,833 (-)Ensembl
RefSeq Acc Id: XM_038449225   ⟹   XP_038305153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1522,543,122 - 22,644,822 (-)NCBI
RefSeq Acc Id: XM_038496127   ⟹   XP_038352055
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11522,054,871 - 22,156,503 (-)NCBI
RefSeq Acc Id: XM_038496128   ⟹   XP_038352056
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11522,054,871 - 22,156,503 (-)NCBI
RefSeq Acc Id: XM_038558527   ⟹   XP_038414455
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01522,355,750 - 22,457,672 (-)NCBI
RefSeq Acc Id: XM_038558528   ⟹   XP_038414456
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01522,355,750 - 22,457,672 (-)NCBI
RefSeq Acc Id: XM_038622416   ⟹   XP_038478344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01522,115,634 - 22,217,474 (-)NCBI
RefSeq Acc Id: XM_038622417   ⟹   XP_038478345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01522,115,634 - 22,217,474 (-)NCBI
RefSeq Acc Id: XM_038688110   ⟹   XP_038544038
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01522,466,453 - 22,568,184 (-)NCBI
RefSeq Acc Id: XM_038688111   ⟹   XP_038544039
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01522,466,453 - 22,568,184 (-)NCBI
RefSeq Acc Id: XP_038352056   ⟸   XM_038496128
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038352055   ⟸   XM_038496127
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038478345   ⟸   XM_038622417
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038478344   ⟸   XM_038622416
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038544039   ⟸   XM_038688111
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038544038   ⟸   XM_038688110
- Peptide Label: isoform X1
- UniProtKB: A0A8I3N4Q4 (UniProtKB/TrEMBL),   A0A8P0PL60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038305153   ⟸   XM_038449225
- Peptide Label: isoform X3
- UniProtKB: A0A8P0PL60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414456   ⟸   XM_038558528
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038414455   ⟸   XM_038558527
- Peptide Label: isoform X1
- UniProtKB: A0A8I3N4Q4 (UniProtKB/TrEMBL),   A0A8P0PL60 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845010624   ⟸   ENSCAFT00845013686


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000058797 UniProtKB/TrEMBL
  ENSCAFG00845007786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000099702.1 UniProtKB/TrEMBL
  ENSCAFT00845013686 ENTREZGENE
  ENSCAFT00845013686.1 UniProtKB/TrEMBL
InterPro Par-4 UniProtKB/TrEMBL
NCBI Gene PAWR ENTREZGENE
PANTHER PRKC APOPTOSIS WT1 REGULATOR PROTEIN UniProtKB/TrEMBL
  PTHR15093 UniProtKB/TrEMBL
UniProt A0A8I3N4Q4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PL60 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111624 ENTREZGENE