NSUN5 (NOP2/Sun RNA methyltransferase 5) - Rat Genome Database

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Gene: NSUN5 (NOP2/Sun RNA methyltransferase 5) Canis lupus familiaris
Analyze
Symbol: NSUN5
Name: NOP2/Sun RNA methyltransferase 5
RGD ID: 12357504
Description: ENCODES a protein that exhibits methyltransferase activity (inferred); RNA binding (inferred); RNA methyltransferase activity (inferred); INVOLVED IN cerebral cortex development (inferred); cognition (inferred); corpus callosum development (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); intestinal volvulus (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 28S rRNA (cytosine-C(5))-methyltransferase; NOL1/NOP2/Sun domain family, member 5; NOP2/Sun RNA methyltransferase family member 5; probable 28S rRNA (cytosine-C(5))-methyltransferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,887,941 - 6,899,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,888,005 - 6,899,517 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,585,100 - 8,597,403 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,708,346 - 6,720,875 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,708,400 - 6,720,883 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,678,489 - 6,690,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,641,234 - 6,653,754 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,804,538 - 6,816,853 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleolus  (IBA,IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NSUN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,887,941 - 6,899,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,888,005 - 6,899,517 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,585,100 - 8,597,403 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,708,346 - 6,720,875 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,708,400 - 6,720,883 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,678,489 - 6,690,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,641,234 - 6,653,754 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,804,538 - 6,816,853 (+)NCBIUU_Cfam_GSD_1.0
NSUN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,302,516 - 73,308,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,302,516 - 73,308,826 (-)EnsemblGRCh38hg38GRCh38
GRCh37772,716,513 - 72,722,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,355,162 - 72,360,759 (-)NCBINCBI36Build 36hg18NCBI36
Celera768,194,805 - 68,201,154 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef768,598,255 - 68,604,606 (-)NCBIHuRef
CHM1_1772,862,538 - 72,868,889 (-)NCBICHM1_1
T2T-CHM13v2.0774,502,674 - 74,508,983 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,049,585 - 72,055,936 (-)NCBI
Nsun5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,398,784 - 135,405,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,398,807 - 135,405,659 (+)EnsemblGRCm39 Ensembl
GRCm385135,369,930 - 135,376,805 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,369,953 - 135,376,805 (+)EnsemblGRCm38mm10GRCm38
MGSCv375135,845,823 - 135,852,667 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,654,587 - 135,660,770 (+)NCBIMGSCv36mm8
Celera5132,381,655 - 132,388,499 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.16NCBI
Nsun5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,930,204 - 26,935,887 (-)NCBIGRCr8
mRatBN7.21221,293,637 - 21,299,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,293,645 - 21,299,272 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,436,101 - 22,441,065 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,048,433 - 23,053,397 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,114,913 - 22,119,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,341,940 - 24,346,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,341,928 - 24,346,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,339,243 - 26,344,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,448,736 - 22,453,696 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,439,243 - 22,444,280 (-)NCBI
Celera1223,056,841 - 23,061,799 (-)NCBICelera
Cytogenetic Map12q12NCBI
Nsun5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,331,924 - 14,335,973 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,331,890 - 14,336,650 (+)NCBIChiLan1.0ChiLan1.0
NSUN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,592,636 - 91,602,346 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,857,274 - 139,862,769 (+)NCBINHGRI_mPanPan1
PanPan1.1780,454,524 - 80,461,353 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,455,353 - 80,461,316 (-)Ensemblpanpan1.1panPan2
Nsun5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,411,968 - 131,419,043 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,617,532 - 2,621,272 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,618,097 - 2,624,599 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSUN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,632,677 - 10,642,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,632,670 - 10,642,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,337,653 - 10,346,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSUN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,737,722 - 9,743,372 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,737,777 - 9,743,189 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,719,347 - 6,724,999 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsun5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,413,489 - 14,419,340 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,413,451 - 14,418,255 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NSUN5
125 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000021018   ⟹   ENSCAFP00000019518
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl66,888,005 - 6,899,406 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000068826   ⟹   ENSCAFP00000064374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl66,888,005 - 6,899,517 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845006440   ⟹   ENSCAFP00845005123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl66,708,400 - 6,720,883 (+)Ensembl
RefSeq Acc Id: XM_022419576   ⟹   XP_022275284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.166,887,941 - 6,899,515 (+)NCBI
Dog10K_Boxer_Tasha68,585,100 - 8,597,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038477890   ⟹   XP_038333818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.166,678,489 - 6,690,838 (+)NCBI
RefSeq Acc Id: XM_038477891   ⟹   XP_038333819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.166,678,489 - 6,690,121 (+)NCBI
RefSeq Acc Id: XM_038539144   ⟹   XP_038395072
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.066,804,538 - 6,816,853 (+)NCBI
RefSeq Acc Id: XM_038539145   ⟹   XP_038395073
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.066,804,538 - 6,816,136 (+)NCBI
RefSeq Acc Id: XM_038603225   ⟹   XP_038459153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.066,641,234 - 6,653,754 (+)NCBI
RefSeq Acc Id: XM_038603226   ⟹   XP_038459154
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.066,641,234 - 6,653,038 (+)NCBI
RefSeq Acc Id: XM_038667922   ⟹   XP_038523850
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.066,708,346 - 6,720,875 (+)NCBI
RefSeq Acc Id: XM_038667923   ⟹   XP_038523851
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.066,708,346 - 6,720,159 (+)NCBI
RefSeq Acc Id: XM_536846   ⟹   XP_536846
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.166,887,941 - 6,899,515 (+)NCBI
Dog10K_Boxer_Tasha68,585,100 - 8,596,686 (+)NCBI
Sequence:
RefSeq Acc Id: XP_536846   ⟸   XM_536846
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MWW7 (UniProtKB/TrEMBL),   A0A8I3MRS9 (UniProtKB/TrEMBL),   A0A8C0SET0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022275284   ⟸   XM_022419576
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N3V8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000064374   ⟸   ENSCAFT00000068826
Ensembl Acc Id: ENSCAFP00000019518   ⟸   ENSCAFT00000021018
RefSeq Acc Id: XP_038333818   ⟸   XM_038477890
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038333819   ⟸   XM_038477891
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459153   ⟸   XM_038603225
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459154   ⟸   XM_038603226
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038523850   ⟸   XM_038667922
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N3V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038523851   ⟸   XM_038667923
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MWW7 (UniProtKB/TrEMBL),   A0A8I3MRS9 (UniProtKB/TrEMBL),   A0A8C0SET0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395072   ⟸   XM_038539144
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N3V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395073   ⟸   XM_038539145
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SET0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845005123   ⟸   ENSCAFT00845006440
Protein Domains
SAM-dependent MTase RsmB/NOP-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013197 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010957 UniProtKB/TrEMBL
  ENSCAFG00040012269 UniProtKB/TrEMBL
  ENSCAFG00845003615 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021018.5 UniProtKB/TrEMBL
  ENSCAFT00030020714.1 UniProtKB/TrEMBL
  ENSCAFT00030020792.1 UniProtKB/TrEMBL
  ENSCAFT00040023122.1 UniProtKB/TrEMBL
  ENSCAFT00845006440 ENTREZGENE
  ENSCAFT00845006440.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  Sun protein, domain 3 UniProtKB/TrEMBL
InterPro MeTrfase_RsmB-F_NOP2_cat UniProtKB/TrEMBL
  MeTrfase_RsmB/NOP2 UniProtKB/TrEMBL
  NSUN5_7_fdxn-like UniProtKB/TrEMBL
  NSUN5_RCM1_N UniProtKB/TrEMBL
  RCMT UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
NCBI Gene NSUN5 ENTREZGENE
PANTHER 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE UniProtKB/TrEMBL
  PTHR22807 UniProtKB/TrEMBL
Pfam Methyltr_RsmB-F UniProtKB/TrEMBL
  NSUN5_fdxn-like UniProtKB/TrEMBL
  NSUN5_N UniProtKB/TrEMBL
PRINTS RCMTFAMILY UniProtKB/TrEMBL
PROSITE SAM_MT_RSMB_NOP UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8C0MWW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N3V8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SET0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MRS9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:59396 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-05 NSUN5  NOP2/Sun RNA methyltransferase 5    NOP2/Sun RNA methyltransferase family member 5  Symbol and/or name change 5135510 APPROVED