IL5 (interleukin 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: IL5 (interleukin 5) Canis lupus familiaris
Analyze
Symbol: IL5
Name: interleukin 5
RGD ID: 12350093
Description: ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-5 receptor binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of B cell proliferation (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-4 signaling pathway; interleukin-5 signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); allergic contact dermatitis (ortholog); allergic rhinitis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eosinophil differentiation factor; IL-5; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; T-cell replacing factor; TRF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,825,469 - 20,827,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
angiostrongyliasis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Churg-Strauss syndrome  (ISO)
colitis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
Cytomegalovirus Infections  (ISO)
echinococcosis  (ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
eosinophilic esophagitis  (ISO)
eosinophilic gastroenteritis  (ISO)
esophageal cancer  (ISO)
Experimental Autoimmune Neuritis  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis 1  (ISO)
food allergy  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
IgA vasculitis  (ISO)
inflammatory bowel disease  (ISO)
major depressive disorder  (ISO)
middle cerebral artery infarction  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
Parasitic Intestinal Diseases  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
prostatic hypertrophy  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sickle cell anemia  (ISO)
status asthmaticus  (ISO)
stomach cancer  (ISO)
strongyloidiasis  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
urinary schistosomiasis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11440633   PMID:22301074  


Genomics

Comparative Map Data
IL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,825,469 - 20,827,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBIUU_Cfam_GSD_1.0
IL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,541,445 - 132,556,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,541,445 - 132,556,838 (-)EnsemblGRCh38hg38GRCh38
GRCh375131,877,137 - 131,879,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,905,035 - 131,907,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 345131,905,034 - 131,907,113NCBI
Celera5128,007,258 - 128,009,336 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,069,401 - 127,071,479 (-)NCBIHuRef
CHM1_15131,310,410 - 131,312,488 (-)NCBICHM1_1
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBIT2T-CHM13v2.0
Il5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,611,621 - 53,615,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)EnsemblGRCm39 Ensembl
GRCm381153,720,794 - 53,725,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,534,296 - 53,538,605 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,564,217 - 53,568,526 (+)NCBIMGSCv36mm8
Celera1158,300,334 - 58,304,644 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.99NCBI
Il5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,375,132 - 38,378,003 (+)NCBIGRCr8
mRatBN7.21037,874,342 - 37,877,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,566,241 - 42,569,117 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,056,311 - 42,059,187 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,560,033 - 37,562,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
Celera1037,217,913 - 37,220,782 (+)NCBICelera
RH 3.4 Map10405.8RGD
Cytogenetic Map10q22NCBI
Il5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,937,894 - 3,939,358 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,937,128 - 3,951,784 (-)NCBIChiLan1.0ChiLan1.0
IL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,852,984 - 127,868,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,985,380 - 126,007,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,955,377 - 127,961,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,119,608 - 134,121,682 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,119,608 - 134,121,675 (-)Ensemblpanpan1.1panPan2
Il5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,832,147 - 134,835,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,832,143 - 134,846,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,301,702 - 140,315,329 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,360,143 - 35,375,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,360,506 - 35,362,178 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,568,292 - 42,583,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,556,797 - 39,559,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,544,487 - 39,558,943 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL5
15 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000001335   ⟹   ENSCAFP00000001224
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000045599   ⟹   ENSCAFP00000037706
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1120,825,469 - 20,827,241 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845018628   ⟹   ENSCAFP00845014535
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845018643   ⟹   ENSCAFP00845014550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,188 (-)Ensembl
RefSeq Acc Id: NM_001006950   ⟹   NP_001006951
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11120,825,469 - 20,827,269 (-)NCBI
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBI
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBI
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBI
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBI
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001006951 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD46991 (Get FASTA)   NCBI Sequence Viewer  
  AAL10715 (Get FASTA)   NCBI Sequence Viewer  
  AAL10716 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000001224.1
  ENSCAFP00030019368.1
  ENSCAFP00040009848.1
  ENSCAFP00845014535
  ENSCAFP00845014535.1
GenBank Protein Q95J76 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006951   ⟸   NM_001006950
- Peptide Label: precursor
- UniProtKB: Q95J76 (UniProtKB/Swiss-Prot),   A0A8C0KMU0 (UniProtKB/TrEMBL),   A0A8C0QJQ5 (UniProtKB/TrEMBL),   A0A8I3NFI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001224   ⟸   ENSCAFT00000001335
Ensembl Acc Id: ENSCAFP00000037706   ⟸   ENSCAFT00000045599
Ensembl Acc Id: ENSCAFP00845014535   ⟸   ENSCAFT00845018628
Ensembl Acc Id: ENSCAFP00845014550   ⟸   ENSCAFT00845018643


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000855 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030011982 UniProtKB/Swiss-Prot
  ENSCAFG00040006091 UniProtKB/Swiss-Prot
  ENSCAFG00845010566 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000001335.3 UniProtKB/Swiss-Prot
  ENSCAFT00030022203.1 UniProtKB/Swiss-Prot
  ENSCAFT00040011369.1 UniProtKB/Swiss-Prot
  ENSCAFT00845018628 ENTREZGENE
  ENSCAFT00845018628.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-5 UniProtKB/Swiss-Prot
KEGG Report cfa:403790 UniProtKB/Swiss-Prot
NCBI Gene IL5 ENTREZGENE
PANTHER INTERLEUKIN-5 UniProtKB/Swiss-Prot
  INTERLEUKIN-5 UniProtKB/Swiss-Prot
Pfam IL5 UniProtKB/Swiss-Prot
PRINTS INTERLEUKIN5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A8C0KMU0 ENTREZGENE
  A0A8C0QJQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NFI1 ENTREZGENE, UniProtKB/TrEMBL
  IL5_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q9TV10_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41990 ENTREZGENE