BCL11B (BCL11 transcription factor B) - Rat Genome Database

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Gene: BCL11B (BCL11 transcription factor B) Canis lupus familiaris
Analyze
Symbol: BCL11B
Name: BCL11 transcription factor B
RGD ID: 12343557
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN alpha-beta T cell differentiation (inferred); apoptotic process (inferred); axonogenesis (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); combined immunodeficiency (ortholog); COVID-19 (ortholog); FOUND IN neuron projection (inferred); nucleus (inferred); SWI/SNF complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: B cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell lymphoma/leukemia 11B; BAF chromatin remodeling complex subunit BCL11B; BCL11B, BAF complex component
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1867,622,592 - 67,713,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl867,622,708 - 67,714,404 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,145,953 - 67,237,226 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0867,909,299 - 68,000,574 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl867,909,387 - 68,001,543 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1867,570,743 - 67,661,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0867,636,646 - 67,728,187 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,033,837 - 68,125,174 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
BCL11B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1867,622,592 - 67,713,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl867,622,708 - 67,714,404 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,145,953 - 67,237,226 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0867,909,299 - 68,000,574 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl867,909,387 - 68,001,543 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1867,570,743 - 67,661,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0867,636,646 - 67,728,187 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,033,837 - 68,125,174 (-)NCBIUU_Cfam_GSD_1.0
BCL11B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,169,287 - 99,272,197 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,169,287 - 99,272,197 (-)EnsemblGRCh38hg38GRCh38
GRCh371499,635,624 - 99,738,534 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361498,705,377 - 98,807,575 (-)NCBINCBI36Build 36hg18NCBI36
Build 341498,705,376 - 98,807,575NCBI
Celera1479,691,368 - 79,793,512 (-)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1479,819,226 - 79,921,464 (-)NCBIHuRef
CHM1_11499,573,389 - 99,675,578 (-)NCBICHM1_1
T2T-CHM13v2.01493,400,844 - 93,503,767 (-)NCBIT2T-CHM13v2.0
Bcl11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912107,876,662 - 107,970,404 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12107,876,662 - 107,969,861 (-)EnsemblGRCm39 Ensembl
GRCm3812107,910,403 - 108,004,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12107,910,403 - 108,003,602 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712109,148,613 - 109,241,624 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,363,030 - 108,451,028 (-)NCBIMGSCv36mm8
Celera12109,151,974 - 109,245,238 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.1NCBI
Bcl11b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86132,598,968 - 132,692,123 (-)NCBIGRCr8
mRatBN7.26126,834,531 - 126,927,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6126,834,531 - 126,928,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6126,958,692 - 127,050,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,253,714 - 127,345,900 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06126,612,161 - 126,704,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06131,834,097 - 131,927,251 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6131,834,097 - 131,926,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,004,477 - 141,097,643 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,292,671 - 132,384,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16132,296,789 - 132,389,378 (-)NCBI
Celera6124,393,881 - 124,486,186 (-)NCBICelera
Cytogenetic Map6q32NCBI
Bcl11b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,564,449 - 20,637,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543820,562,345 - 20,637,662 (-)NCBIChiLan1.0ChiLan1.0
BCL11B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,325,797 - 100,429,008 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11499,542,293 - 99,645,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01479,795,262 - 79,898,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,122,231 - 99,205,962 (-)NCBIpanpan1.1PanPan1.1panPan2
Bcl11b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,972,307 - 7,063,288 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,023,844 - 3,110,083 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,023,781 - 3,110,104 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL11B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,205,008 - 120,295,936 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17120,205,008 - 120,295,737 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27127,759,537 - 127,855,267 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL11B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,122,591 - 77,222,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,122,689 - 77,221,454 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605364,224,342 - 64,347,710 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl11b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,560,699 - 4,647,858 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247344,560,362 - 4,649,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BCL11B
1197 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005623788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005623789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005623790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005623791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000028248   ⟹   ENSCAFP00000026270
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl867,622,708 - 67,714,404 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000044077   ⟹   ENSCAFP00000042957
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl867,622,708 - 67,714,404 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006895   ⟹   ENSCAFP00845005492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl867,909,387 - 68,001,543 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006902   ⟹   ENSCAFP00845005498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl867,909,387 - 68,001,543 (-)Ensembl
RefSeq Acc Id: XM_005623788   ⟹   XP_005623845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1867,622,592 - 67,713,922 (-)NCBI
Dog10K_Boxer_Tasha867,145,953 - 67,237,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005623789   ⟹   XP_005623846
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1867,622,592 - 67,713,922 (-)NCBI
Dog10K_Boxer_Tasha867,145,953 - 67,237,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005623791   ⟹   XP_005623848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1867,622,592 - 67,713,922 (-)NCBI
Dog10K_Boxer_Tasha867,145,953 - 67,237,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038484177   ⟹   XP_038340105
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1867,570,743 - 67,661,895 (-)NCBI
RefSeq Acc Id: XM_038484178   ⟹   XP_038340106
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1867,570,743 - 67,661,895 (-)NCBI
RefSeq Acc Id: XM_038484179   ⟹   XP_038340107
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1867,570,743 - 67,661,895 (-)NCBI
RefSeq Acc Id: XM_038545688   ⟹   XP_038401616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0868,033,837 - 68,125,174 (-)NCBI
RefSeq Acc Id: XM_038545689   ⟹   XP_038401617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0868,033,837 - 68,125,174 (-)NCBI
RefSeq Acc Id: XM_038545691   ⟹   XP_038401619
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0868,033,837 - 68,125,174 (-)NCBI
RefSeq Acc Id: XM_038609787   ⟹   XP_038465715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0867,636,646 - 67,728,187 (-)NCBI
RefSeq Acc Id: XM_038674604   ⟹   XP_038530532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0867,909,299 - 68,000,574 (-)NCBI
RefSeq Acc Id: XM_038674605   ⟹   XP_038530533
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0867,909,299 - 68,000,574 (-)NCBI
RefSeq Acc Id: XM_038674606   ⟹   XP_038530534
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0867,909,299 - 68,000,574 (-)NCBI
RefSeq Acc Id: XP_005623845   ⟸   XM_005623788
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RT61 (UniProtKB/TrEMBL),   A0A8P0NJ09 (UniProtKB/TrEMBL),   A0A8C0REY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005623846   ⟸   XM_005623789
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KB90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005623848   ⟸   XM_005623791
- Peptide Label: isoform X3
- UniProtKB: A0A8C0REY3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000026270   ⟸   ENSCAFT00000028248
Ensembl Acc Id: ENSCAFP00000042957   ⟸   ENSCAFT00000044077
RefSeq Acc Id: XP_038340106   ⟸   XM_038484178
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038340107   ⟸   XM_038484179
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038340105   ⟸   XM_038484177
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038465715   ⟸   XM_038609787
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038530533   ⟸   XM_038674605
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RT61 (UniProtKB/TrEMBL),   A0A8P0NJ09 (UniProtKB/TrEMBL),   A0A8C0REY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530534   ⟸   XM_038674606
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KB90 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530532   ⟸   XM_038674604
- Peptide Label: isoform X3
- UniProtKB: A0A8C0REY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401617   ⟸   XM_038545689
- Peptide Label: isoform X1
- UniProtKB: A0A8C0REY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401619   ⟸   XM_038545691
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KB90 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401616   ⟸   XM_038545688
- Peptide Label: isoform X3
- UniProtKB: A0A8C0REY3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845005498   ⟸   ENSCAFT00845006902
Ensembl Acc Id: ENSCAFP00845005492   ⟸   ENSCAFT00845006895
Protein Domains
C2H2-type

Promoters
RGD ID:13684333
Promoter ID:EPDNEW_C2402
Type:initiation region
Name:BCL11B_1
Description:B cell CLL/lymphoma 11B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1867,713,935 - 67,713,995EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017809 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007762 UniProtKB/TrEMBL
  ENSCAFG00040000625 UniProtKB/TrEMBL
  ENSCAFG00845003846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028248.7 UniProtKB/TrEMBL
  ENSCAFT00000044077.4 UniProtKB/TrEMBL
  ENSCAFT00030014215.1 UniProtKB/TrEMBL
  ENSCAFT00030014266.1 UniProtKB/TrEMBL
  ENSCAFT00040001096.1 UniProtKB/TrEMBL
  ENSCAFT00040001109.1 UniProtKB/TrEMBL
  ENSCAFT00845006895 ENTREZGENE
  ENSCAFT00845006895.1 UniProtKB/TrEMBL
  ENSCAFT00845006902 ENTREZGENE
  ENSCAFT00845006902.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Dev/Hematopoietic_TF UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report cfa:612476 UniProtKB/TrEMBL
NCBI Gene BCL11B ENTREZGENE
PANTHER B-CELL LYMPHOMA/LEUKEMIA 11 UniProtKB/TrEMBL
  B-CELL LYMPHOMA/LEUKEMIA 11B UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0KB90 ENTREZGENE
  A0A8C0PLL9_CANLF UniProtKB/TrEMBL
  A0A8C0REY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQJ1_CANLF UniProtKB/TrEMBL
  A0A8I3RT61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NJ09 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SWE5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:57981 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-12 BCL11B  BCL11 transcription factor B  BCL11B  BAF chromatin remodeling complex subunit BCL11B  Symbol and/or name change 19259463 PROVISIONAL
2019-01-30 BCL11B  BAF chromatin remodeling complex subunit BCL11B    BCL11B, BAF complex component  Symbol and/or name change 5135510 APPROVED
2018-11-06 BCL11B  BCL11B, BAF complex component    B cell CLL/lymphoma 11B  Symbol and/or name change 5135510 APPROVED
2017-12-19 BCL11B  B cell CLL/lymphoma 11B    B-cell CLL/lymphoma 11B  Symbol and/or name change 5135510 APPROVED