BMP6 (bone morphogenetic protein 6) - Rat Genome Database

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Gene: BMP6 (bone morphogenetic protein 6) Canis lupus familiaris
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Symbol: BMP6
Name: bone morphogenetic protein 6
RGD ID: 12338962
Description: ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cellular response to mechanical stimulus (ortholog); endochondral ossification (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH Acute Otitis Media (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic contact dermatitis (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IBA,IEA,ISO)
bone development  (IEA)
cellular response to BMP stimulus  (IEA)
cellular response to iron ion  (IEA)
cellular response to mechanical stimulus  (ISO)
endochondral ossification  (IEA,ISO)
eye development  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
intracellular iron ion homeostasis  (IEA,ISO)
kidney development  (IEA)
male genitalia development  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA)
negative regulation of adherens junction organization  (IEA)
negative regulation of cell-cell adhesion mediated by cadherin  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
neuron differentiation  (IEA,ISO)
ossification  (ISO)
osteoblast differentiation  (IEA,ISO)
positive regulation of aldosterone biosynthetic process  (IEA)
positive regulation of aldosterone secretion  (ISO)
positive regulation of bone mineralization  (IEA)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of endothelial cell differentiation  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IEA)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of vascular permeability  (IEA)
response to activity  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to magnesium ion  (ISO)
response to retinoic acid  (ISO)
signal transduction  (IEA)
type B pancreatic cell development  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BMP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBIUU_Cfam_GSD_1.0
BMP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3867,726,099 - 7,881,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl67,726,099 - 7,881,728 (+)EnsemblGRCh38hg38GRCh38
GRCh3767,726,332 - 7,881,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,672,010 - 7,826,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 3467,672,008 - 7,826,726NCBI
Celera68,956,438 - 9,111,399 (+)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef67,604,128 - 7,759,039 (+)NCBIHuRef
CHM1_167,728,829 - 7,884,079 (+)NCBICHM1_1
T2T-CHM13v2.067,594,835 - 7,750,477 (+)NCBIT2T-CHM13v2.0
Bmp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,529,098 - 38,684,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1338,529,083 - 38,684,278 (+)EnsemblGRCm39 Ensembl
GRCm381338,345,716 - 38,500,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,345,107 - 38,500,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,437,585 - 38,591,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361338,353,182 - 38,507,194 (+)NCBIMGSCv36mm8
Celera1339,464,167 - 39,615,905 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.15NCBI
Bmp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,523,704 - 26,785,558 (-)NCBIGRCr8
mRatBN7.21726,318,121 - 26,469,691 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,318,569 - 26,470,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1726,176,967 - 26,326,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01727,780,553 - 27,930,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01726,125,854 - 26,275,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01726,955,142 - 27,112,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01728,870,345 - 29,029,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,380,199 - 32,689,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,383,039 - 32,692,136 (-)NCBI
Celera1725,955,026 - 26,103,008 (-)NCBICelera
RH 3.4 Map17342.3RGD
Cytogenetic Map17p12NCBI
Bmp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,054,931 - 6,200,377 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,053,600 - 6,201,254 (-)NCBIChiLan1.0ChiLan1.0
BMP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2522,365,813 - 22,522,551 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1618,363,471 - 18,519,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v067,564,164 - 7,720,341 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.167,848,255 - 8,002,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,848,249 - 8,000,649 (+)Ensemblpanpan1.1panPan2
Bmp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494616,438,976 - 16,602,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365344,709,064 - 4,871,023 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365344,707,658 - 4,871,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl75,058,817 - 5,210,270 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.175,058,817 - 5,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.275,163,209 - 5,313,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,279,243 - 64,436,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1764,280,609 - 64,435,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660447,712,261 - 7,873,910 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475617,743,834 - 17,894,753 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BMP6
747 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000047626   ⟹   ENSCAFP00000038289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845031258   ⟹   ENSCAFP00845024468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845031341   ⟹   ENSCAFP00845024537
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845031399   ⟹   ENSCAFP00845024586
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)Ensembl
RefSeq Acc Id: XM_038446326   ⟹   XP_038302254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBI
RefSeq Acc Id: XM_038463028   ⟹   XP_038318956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBI
RefSeq Acc Id: XM_038520493   ⟹   XP_038376421
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBI
RefSeq Acc Id: XM_038584127   ⟹   XP_038440055
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBI
RefSeq Acc Id: XM_038648534   ⟹   XP_038504462
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBI
Ensembl Acc Id: ENSCAFP00000038289   ⟸   ENSCAFT00000047626
RefSeq Acc Id: XP_038376421   ⟸   XM_038520493
RefSeq Acc Id: XP_038504462   ⟸   XM_038648534
RefSeq Acc Id: XP_038302254   ⟸   XM_038446326
- UniProtKB: A0A8I3P8R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038318956   ⟸   XM_038463028
- UniProtKB: A0A8C0N1V9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440055   ⟸   XM_038584127
- UniProtKB: A0A8C0N1V9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845024586   ⟸   ENSCAFT00845031399
Ensembl Acc Id: ENSCAFP00845024468   ⟸   ENSCAFT00845031258
Ensembl Acc Id: ENSCAFP00845024537   ⟸   ENSCAFT00845031341
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032289 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012573 UniProtKB/TrEMBL
  ENSCAFG00845017586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047626.3 UniProtKB/TrEMBL
  ENSCAFT00030023271.1 UniProtKB/TrEMBL
  ENSCAFT00845031258 ENTREZGENE
  ENSCAFT00845031258.1 UniProtKB/TrEMBL
  ENSCAFT00845031341.1 UniProtKB/TrEMBL
  ENSCAFT00845031399.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene BMP6 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 6 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C0N1V9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P2W1_CANLF UniProtKB/TrEMBL
  A0A8I3P8R9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S2T7_CANLF UniProtKB/TrEMBL
  A0A8P0SST4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:59134 ENTREZGENE