TH (tyrosine hydroxylase) - Rat Genome Database

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Gene: TH (tyrosine hydroxylase) Canis lupus familiaris
Analyze
Symbol: TH
Name: tyrosine hydroxylase
RGD ID: 12338461
Description: ENCODES a protein that exhibits amino acid binding (ortholog); dopamine binding (ortholog); ferric iron binding (ortholog); INVOLVED IN aminergic neurotransmitter loading into synaptic vesicle (ortholog); catecholamine biosynthetic process (ortholog); cellular response to alkaloid (ortholog); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; ASSOCIATED WITH brain disease (ortholog); Brain Injuries (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,327,136 - 46,334,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aminergic neurotransmitter loading into synaptic vesicle  (ISO)
animal organ morphogenesis  (IEA)
aromatic amino acid metabolic process  (IEA)
catecholamine biosynthetic process  (IEA,ISO)
cellular response to alkaloid  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nicotine  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (ISO)
circadian sleep/wake cycle  (ISO)
cognition  (IBA,ISO)
dopamine biosynthetic process  (IEA)
dopamine biosynthetic process from tyrosine  (IBA,IEA,ISO)
eating behavior  (IEA)
embryonic camera-type eye morphogenesis  (IEA)
epinephrine biosynthetic process  (IBA,IEA)
eye photoreceptor cell development  (IEA)
fatty acid metabolic process  (ISO)
heart development  (IEA,ISO)
hyaloid vascular plexus regression  (IEA,ISS)
learning  (IEA)
locomotory behavior  (IEA)
mating behavior  (IBA,IEA)
memory  (IEA)
norepinephrine biosynthetic process  (IBA,IEA)
phthalate metabolic process  (ISO)
regulation of heart contraction  (IEA)
response to activity  (ISO)
response to amphetamine  (ISO)
response to corticosterone  (ISO)
response to curcumin  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ethanol  (IEA,ISO)
response to ether  (ISO)
response to growth factor  (ISO)
response to herbicide  (ISO)
response to hypoxia  (IEA,ISO)
response to immobilization stress  (ISO)
response to insecticide  (ISO)
response to isolation stress  (ISO)
response to light stimulus  (ISO)
response to lipopolysaccharide  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to pyrethroid  (ISO)
response to salt stress  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
serotonin biosynthetic process  (IBA)
social behavior  (ISO)
sphingolipid metabolic process  (ISO)
synaptic transmission, dopaminergic  (IBA,IEA)
visual perception  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:16210796   PMID:19954797   PMID:22272320   PMID:22301074   PMID:23713429   PMID:30032202   PMID:37185969  


Genomics

Comparative Map Data
TH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,327,136 - 46,334,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,163,929 - 2,171,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,163,929 - 2,171,968 (-)Ensemblhg38GRCh38
GRCh37112,185,159 - 2,193,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,141,735 - 2,149,611 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,141,735 - 2,149,605NCBI
Celera112,221,752 - 2,229,624 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,975,424 - 1,983,299 (-)NCBIHuRef
CHM1_1112,183,941 - 2,191,817 (-)NCBICHM1_1
T2T-CHM13v2.0112,253,295 - 2,261,192 (-)NCBIT2T-CHM13v2.0
Th
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,446,516 - 142,453,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,446,489 - 142,484,865 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)Ensemblmm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBIMGSCv36mm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
Th
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,500,959 - 207,508,276 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,500,962 - 207,557,227 (-)EnsemblGRCr8
mRatBN7.21198,071,500 - 198,078,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,071,503 - 198,109,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,450,387 - 206,457,507 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,537,252 - 213,544,373 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,211,403 - 206,218,524 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
Th
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,943,552 - 13,951,137 (-)Ensembl
ChiLan1.0NW_00495542213,943,590 - 13,951,102 (-)NCBIChiLan1.0ChiLan1.0
TH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,590,095 - 4,597,992 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,801,867 - 3,809,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,204,820 - 2,212,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,234,095 - 2,242,030 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,231,248 - 2,242,433 (-)EnsemblpanPan2panpan1.1
Th
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,535,447 - 2,543,939 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794478,614 - 487,061 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936794478,651 - 486,887 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,499,620 - 1,506,170 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.121,499,628 - 1,506,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,969,194 - 1,977,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,966,460 - 1,977,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603899,163,059 - 99,174,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Th
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,003,092 - 15,010,154 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Th
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11142,498,594 - 42,505,727 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in TH
126 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 2 5 21 19 9 3 6 3 4 23 18 12 14 6

Sequence


Ensembl Acc Id: ENSCAFT00000016050   ⟹   ENSCAFP00000014845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000067553   ⟹   ENSCAFP00000062830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000069096   ⟹   ENSCAFP00000060760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000082695   ⟹   ENSCAFP00000045232
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845019917   ⟹   ENSCAFP00845015602
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845020025   ⟹   ENSCAFP00845015691
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845020091   ⟹   ENSCAFP00845015745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845020176   ⟹   ENSCAFP00845015814
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)Ensembl
RefSeq Acc Id: NM_001002966   ⟹   NP_001002966
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11846,327,136 - 46,334,973 (-)NCBI
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBI
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBI
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBI
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBI
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002966 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC82588 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00845015602
GenBank Protein Q76IQ3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001002966   ⟸   NM_001002966
- UniProtKB: Q76IQ3 (UniProtKB/Swiss-Prot),   A0A8C0NL54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000060760   ⟸   ENSCAFT00000069096
Ensembl Acc Id: ENSCAFP00000062830   ⟸   ENSCAFT00000067553
Ensembl Acc Id: ENSCAFP00000045232   ⟸   ENSCAFT00000082695
Ensembl Acc Id: ENSCAFP00000014845   ⟸   ENSCAFT00000016050
Ensembl Acc Id: ENSCAFP00845015745   ⟸   ENSCAFT00845020091
Ensembl Acc Id: ENSCAFP00845015691   ⟸   ENSCAFT00845020025
Ensembl Acc Id: ENSCAFP00845015814   ⟸   ENSCAFT00845020176
Ensembl Acc Id: ENSCAFP00845015602   ⟸   ENSCAFT00845019917
Protein Domains
Biopterin-dependent aromatic amino acid hydroxylase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010099 Ensembl
  ENSCAFG00845011201 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845019917 ENTREZGENE
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot
  3.30.70.260 UniProtKB/Swiss-Prot
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot
  ArAA_hydroxylase UniProtKB/Swiss-Prot
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot
  Eu_TyrOH_cat UniProtKB/Swiss-Prot
  TH_ACT UniProtKB/Swiss-Prot
  Tyr_3_mOase UniProtKB/Swiss-Prot
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot
  Tyrosine_hydroxylase_CS UniProtKB/Swiss-Prot
KEGG Report cfa:403444 UniProtKB/Swiss-Prot
NCBI Gene TH ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot
  TYROSINE 3-MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam Biopterin_H UniProtKB/Swiss-Prot
  TH_ACT UniProtKB/Swiss-Prot
  TOH_N UniProtKB/Swiss-Prot
PIRSF PIRSF000336 UniProtKB/Swiss-Prot
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot
PROSITE BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot
  SSF56534 UniProtKB/Swiss-Prot
UniProt A0A8C0NL54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NMD2_CANLF UniProtKB/TrEMBL
  A0A8C0NQE7_CANLF UniProtKB/TrEMBL
  A0A8C0TVH0_CANLF UniProtKB/TrEMBL
  A0A8I3NH07_CANLF UniProtKB/TrEMBL
  A0A8I3NKB3_CANLF UniProtKB/TrEMBL
  A0A8I3NUF2_CANLF UniProtKB/TrEMBL
  A0A8I3RWF7_CANLF UniProtKB/TrEMBL
  A0A8P0PBP3_CANLF UniProtKB/TrEMBL
  A0A8P0SF78_CANLF UniProtKB/TrEMBL
  A0A8P0SYA3_CANLF UniProtKB/TrEMBL
  A0A8P0TCL4_CANLF UniProtKB/TrEMBL
  Q76IQ3 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:47322 ENTREZGENE