ASIC1 (acid sensing ion channel subunit 1) - Rat Genome Database

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Gene: ASIC1 (acid sensing ion channel subunit 1) Canis lupus familiaris
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Symbol: ASIC1
Name: acid sensing ion channel subunit 1
RGD ID: 12305086
Description: ENCODES a protein that exhibits inorganic cation transmembrane transporter activity (ortholog); monoatomic ion channel activity (ortholog); pH-gated monoatomic ion channel activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral fear response (ortholog); calcium ion transmembrane transport (ortholog); ASSOCIATED WITH Brain Injuries (ortholog); brain ischemia (ortholog); epilepsy (ortholog); FOUND IN cell surface (ortholog); glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ACCN2; acid-sensing (proton-gated) ion channel 1; acid-sensing ion channel 1; amiloride-sensitive cation channel 2, neuronal
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,638,826 - 4,663,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,594,907 - 41,619,336 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,687,973 - 4,712,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,687,975 - 4,711,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,652,821 - 4,677,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,642,373 - 4,667,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,989,720 - 42,014,370 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,638,826 - 4,663,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,594,907 - 41,619,336 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,687,973 - 4,712,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,687,975 - 4,711,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,652,821 - 4,677,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,642,373 - 4,667,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,989,720 - 42,014,370 (+)NCBIUU_Cfam_GSD_1.0
ASIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381250,057,596 - 50,083,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1250,057,548 - 50,083,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,451,379 - 50,477,394 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,737,754 - 48,763,661 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,737,753 - 48,763,660NCBI
Celera1249,246,955 - 49,272,856 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,485,455 - 47,510,311 (+)NCBIHuRef
CHM1_11250,417,567 - 50,443,552 (+)NCBICHM1_1
T2T-CHM13v2.01250,020,656 - 50,046,680 (+)NCBIT2T-CHM13v2.0
Asic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,568,090 - 99,599,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,568,249 - 99,599,011 (+)EnsemblGRCm39 Ensembl
GRCm381599,670,197 - 99,701,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,670,368 - 99,701,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,501,149 - 99,531,559 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,498,752 - 99,529,162 (+)NCBIMGSCv36mm8
Celera15101,826,413 - 101,856,974 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Asic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,677,158 - 132,707,379 (+)NCBIGRCr8
mRatBN7.27130,798,317 - 130,828,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,799,917 - 130,828,541 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,603,489 - 132,632,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,829,075 - 134,857,723 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,741,599 - 134,770,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,324,714 - 141,354,937 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,414,656 - 138,443,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,491,092 - 138,517,829 (+)NCBI
Celera7127,281,326 - 127,309,938 (+)NCBICelera
Cytogenetic Map7q36NCBI
Asic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547635,638 - 658,541 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547635,714 - 658,541 (+)NCBIChiLan1.0ChiLan1.0
ASIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,105,768 - 44,132,086 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,102,536 - 44,128,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,672,253 - 38,698,247 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,569,149 - 39,593,822 (-)NCBIpanpan1.1PanPan1.1panPan2
Asic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,418,273 - 65,444,825 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,720,523 - 7,746,579 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,720,591 - 7,746,557 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,965,084 - 15,991,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,965,082 - 15,991,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,354,884 - 16,365,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASIC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,286,665 - 46,313,016 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1146,287,787 - 46,314,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037199,808,378 - 199,835,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asic1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,228,440 - 2,253,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,228,440 - 2,253,798 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ASIC1
317 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005636861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022411216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022411217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038438210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038438211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038577619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038577620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_845307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000013226   ⟹   ENSCAFP00000012241
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000046215   ⟹   ENSCAFP00000042111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845031484   ⟹   ENSCAFP00845024654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl274,687,975 - 4,697,345 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845031562   ⟹   ENSCAFP00845024707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl274,688,753 - 4,711,469 (-)Ensembl
RefSeq Acc Id: XM_005636861   ⟹   XP_005636918
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1274,638,826 - 4,648,246 (-)NCBI
Dog10K_Boxer_Tasha2741,609,909 - 41,619,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038438210   ⟹   XP_038294138
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0274,687,973 - 4,697,403 (-)NCBI
RefSeq Acc Id: XM_038438211   ⟹   XP_038294139
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0274,687,973 - 4,712,419 (-)NCBI
RefSeq Acc Id: XM_038512912   ⟹   XP_038368840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1274,652,821 - 4,677,403 (-)NCBI
RefSeq Acc Id: XM_038577619   ⟹   XP_038433547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02742,004,928 - 42,014,370 (+)NCBI
RefSeq Acc Id: XM_038577620   ⟹   XP_038433548
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02741,989,720 - 42,014,370 (+)NCBI
RefSeq Acc Id: XM_038640693   ⟹   XP_038496621
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,642,373 - 4,651,825 (-)NCBI
RefSeq Acc Id: XM_038640695   ⟹   XP_038496623
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,642,373 - 4,667,009 (-)NCBI
RefSeq Acc Id: XM_845307   ⟹   XP_850400
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1274,638,826 - 4,663,349 (-)NCBI
Dog10K_Boxer_Tasha2741,594,907 - 41,619,336 (+)NCBI
Sequence:
RefSeq Acc Id: XP_850400   ⟸   XM_845307
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KNW0 (UniProtKB/TrEMBL),   A0A8I3S043 (UniProtKB/TrEMBL),   A0A8C0TKH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005636918   ⟸   XM_005636861
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NUI9 (UniProtKB/TrEMBL),   A0A8P0PS28 (UniProtKB/TrEMBL),   A0A8C0Z533 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000012241   ⟸   ENSCAFT00000013226
Ensembl Acc Id: ENSCAFP00000042111   ⟸   ENSCAFT00000046215
RefSeq Acc Id: XP_038368840   ⟸   XM_038512912
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038496623   ⟸   XM_038640695
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038496621   ⟸   XM_038640693
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038294139   ⟸   XM_038438211
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KNW0 (UniProtKB/TrEMBL),   A0A8I3S043 (UniProtKB/TrEMBL),   A0A8C0TKH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038294138   ⟸   XM_038438210
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NUI9 (UniProtKB/TrEMBL),   A0A8P0PS28 (UniProtKB/TrEMBL),   A0A8C0Z533 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433548   ⟸   XM_038577620
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KNW0 (UniProtKB/TrEMBL),   A0A8C0TKH4 (UniProtKB/TrEMBL),   A0A8I3S043 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433547   ⟸   XM_038577619
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Z533 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845024654   ⟸   ENSCAFT00845031484
Ensembl Acc Id: ENSCAFP00845024707   ⟸   ENSCAFT00845031562


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008318 Ensembl
  ENSCAFG00000053375 UniProtKB/TrEMBL
  ENSCAFG00030025611 UniProtKB/TrEMBL
  ENSCAFG00040023065 UniProtKB/TrEMBL
  ENSCAFG00845017786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000060564.2 UniProtKB/TrEMBL
  ENSCAFT00000100249.1 UniProtKB/TrEMBL
  ENSCAFT00030047330.1 UniProtKB/TrEMBL
  ENSCAFT00040042999.1 UniProtKB/TrEMBL
  ENSCAFT00040043021.1 UniProtKB/TrEMBL
  ENSCAFT00845031484 ENTREZGENE
  ENSCAFT00845031484.1 UniProtKB/TrEMBL
  ENSCAFT00845031562 ENTREZGENE
  ENSCAFT00845031562.1 UniProtKB/TrEMBL
Gene3D-CATH acid-sensing ion channel 1 domain UniProtKB/TrEMBL
  Acid-sensing ion channel domain UniProtKB/TrEMBL
  Acid-sensing ion channels like domains UniProtKB/TrEMBL
  YojJ-like UniProtKB/TrEMBL
InterPro ENaC UniProtKB/TrEMBL
  ENaC_chordates UniProtKB/TrEMBL
  ENaC_CS UniProtKB/TrEMBL
NCBI Gene ASIC1 ENTREZGENE
PANTHER ACID-SENSING ION CHANNEL 1 UniProtKB/TrEMBL
  PTHR11690 UniProtKB/TrEMBL
Pfam ASC UniProtKB/TrEMBL
PRINTS AMINACHANNEL UniProtKB/TrEMBL
PROSITE ASC UniProtKB/TrEMBL
UniProt A0A8C0KNW0 ENTREZGENE
  A0A8C0PMS7_CANLF UniProtKB/TrEMBL
  A0A8C0TKH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z533 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NUI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S043 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PS28 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0NZ81 UniProtKB/TrEMBL
VGNC ID VGNC:38177 ENTREZGENE