RSPO1 (R-spondin 1) - Rat Genome Database

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Gene: RSPO1 (R-spondin 1) Canis lupus familiaris
Analyze
Symbol: RSPO1
Name: R-spondin 1
RGD ID: 12295760
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); positive regulation of non-canonical Wnt signaling pathway (ortholog); positive regulation of protein phosphorylation (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); INTERACTS WITH bisphenol A
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: R-spondin homolog; R-spondin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,857,887 - 4,876,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,856,853 - 4,876,800 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,109,926 - 5,122,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,992,103 - 5,010,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,992,117 - 5,010,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,856,312 - 4,868,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,922,700 - 4,935,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,939,342 - 4,951,919 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18577875  


Genomics

Comparative Map Data
RSPO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,857,887 - 4,876,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,856,853 - 4,876,800 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,109,926 - 5,122,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,992,103 - 5,010,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,992,117 - 5,010,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,856,312 - 4,868,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,922,700 - 4,935,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,939,342 - 4,951,919 (+)NCBIUU_Cfam_GSD_1.0
RSPO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38137,611,350 - 37,634,892 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl137,611,350 - 37,634,892 (-)EnsemblGRCh38hg38GRCh38
GRCh37138,076,951 - 38,100,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36137,849,538 - 37,873,078 (-)NCBINCBI36Build 36hg18NCBI36
Celera136,354,952 - 36,378,499 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef136,194,247 - 36,217,890 (-)NCBIHuRef
CHM1_1138,193,128 - 38,216,770 (-)NCBICHM1_1
T2T-CHM13v2.0137,476,097 - 37,499,638 (-)NCBIT2T-CHM13v2.0
Rspo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394124,880,197 - 124,902,895 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4124,880,223 - 124,902,892 (+)EnsemblGRCm39 Ensembl
GRCm384124,986,401 - 125,009,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4124,986,430 - 125,009,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv374124,663,674 - 124,686,343 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364124,488,734 - 124,511,403 (+)NCBIMGSCv36mm8
Celera4123,309,280 - 123,331,929 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.96NCBI
Rspo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85142,536,162 - 142,557,611 (+)NCBIGRCr8
mRatBN7.25137,251,629 - 137,273,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,251,659 - 137,272,933 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5139,955,621 - 139,976,971 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05141,725,633 - 141,746,983 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05141,732,808 - 141,754,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05142,986,526 - 143,007,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5142,986,526 - 143,007,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05146,755,088 - 146,776,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45144,332,302 - 144,353,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5135,769,647 - 135,791,192 (+)NCBICelera
Cytogenetic Map5q36NCBI
Rspo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545215,415,932 - 15,435,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545215,415,417 - 15,435,616 (-)NCBIChiLan1.0ChiLan1.0
RSPO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,204,370 - 189,227,895 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,333,438 - 188,356,126 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0136,885,176 - 36,907,821 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1138,233,693 - 38,256,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl138,231,764 - 38,256,903 (-)Ensemblpanpan1.1panPan2
Rspo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505854,002,026 - 54,021,671 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647419,827,669 - 19,842,726 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647419,826,808 - 19,846,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RSPO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl693,665,121 - 93,685,197 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1693,664,839 - 93,690,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RSPO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12095,232,114 - 95,255,160 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2095,237,071 - 95,255,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603321,556,202 - 21,575,925 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rspo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476420,341,756 - 20,359,279 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476420,342,629 - 20,363,498 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RSPO1
170 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 3 22 20 14 4 6 4 6 23 14 11 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000005262   ⟹   ENSCAFP00000004870
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl154,856,853 - 4,876,800 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000072711   ⟹   ENSCAFP00000058616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl154,856,853 - 4,875,498 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845054398   ⟹   ENSCAFP00845042745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl154,992,117 - 5,010,264 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845054401   ⟹   ENSCAFP00845042748
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl154,992,117 - 5,009,692 (+)Ensembl
RefSeq Acc Id: NM_001130838   ⟹   NP_001124310
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1154,862,933 - 4,875,498 (+)NCBI
Dog10K_Boxer_Tasha155,109,926 - 5,122,478 (+)NCBI
ROS_Cfam_1.0154,997,104 - 5,009,692 (+)NCBI
UMICH_Zoey_3.1154,856,312 - 4,868,879 (+)NCBI
UNSW_CanFamBas_1.0154,922,700 - 4,935,264 (+)NCBI
UU_Cfam_GSD_1.0154,939,342 - 4,951,919 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038687199   ⟹   XP_038543127
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0154,992,103 - 5,010,264 (+)NCBI
RefSeq Acc Id: XM_038687200   ⟹   XP_038543128
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0154,996,568 - 5,010,264 (+)NCBI
RefSeq Acc Id: XM_038687201   ⟹   XP_038543129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0154,992,557 - 5,010,264 (+)NCBI
RefSeq Acc Id: NP_001124310   ⟸   NM_001130838
- Peptide Label: precursor
- UniProtKB: B4XH82 (UniProtKB/TrEMBL),   A0A8C0QCP5 (UniProtKB/TrEMBL),   F1PYN2 (UniProtKB/TrEMBL),   A0A8C0K6M9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000004870   ⟸   ENSCAFT00000005262
Ensembl Acc Id: ENSCAFP00000058616   ⟸   ENSCAFT00000072711
RefSeq Acc Id: XP_038543127   ⟸   XM_038687199
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCP5 (UniProtKB/TrEMBL),   F1PYN2 (UniProtKB/TrEMBL),   A0A8C0K6M9 (UniProtKB/TrEMBL),   B4XH82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543129   ⟸   XM_038687201
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCP5 (UniProtKB/TrEMBL),   F1PYN2 (UniProtKB/TrEMBL),   A0A8C0K6M9 (UniProtKB/TrEMBL),   B4XH82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543128   ⟸   XM_038687200
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCP5 (UniProtKB/TrEMBL),   F1PYN2 (UniProtKB/TrEMBL),   A0A8C0K6M9 (UniProtKB/TrEMBL),   B4XH82 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845042748   ⟸   ENSCAFT00845054401
Ensembl Acc Id: ENSCAFP00845042745   ⟸   ENSCAFT00845054398
Protein Domains
R-spondin Fu-CRD

Promoters
RGD ID:13685859
Promoter ID:EPDNEW_C3929
Type:initiation region
Name:RSPO1_1
Description:R-spondin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1154,857,662 - 4,857,722EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003280 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017038 UniProtKB/TrEMBL
  ENSCAFG00040005514 UniProtKB/TrEMBL
  ENSCAFG00845030653 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005262.5 UniProtKB/TrEMBL
  ENSCAFT00000072711.2 UniProtKB/TrEMBL
  ENSCAFT00030031508.1 UniProtKB/TrEMBL
  ENSCAFT00030031537.1 UniProtKB/TrEMBL
  ENSCAFT00040010366.1 UniProtKB/TrEMBL
  ENSCAFT00040010393.1 UniProtKB/TrEMBL
  ENSCAFT00845054398 ENTREZGENE
  ENSCAFT00845054398.1 UniProtKB/TrEMBL
  ENSCAFT00845054401.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  R-spondin UniProtKB/TrEMBL
  Rspo_Fu-CRD_dom UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report cfa:608179 UniProtKB/TrEMBL
NCBI Gene RSPO1 ENTREZGENE
PANTHER NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR46987:SF5 UniProtKB/TrEMBL
Pfam Furin-like_2 UniProtKB/TrEMBL
PROSITE TSP1 UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0K6M9 ENTREZGENE
  A0A8C0QCP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QL53_CANLF UniProtKB/TrEMBL
  A0A8I3QYL0_CANLF UniProtKB/TrEMBL
  B4XH82 ENTREZGENE, UniProtKB/TrEMBL
  F1PYN2 ENTREZGENE
UniProt Secondary F1PYN2 UniProtKB/TrEMBL
VGNC ID VGNC:45782 ENTREZGENE