MT2A (metallothionein 1H) - Rat Genome Database

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Gene: MT2A (metallothionein 1H) Canis lupus familiaris
Analyze
Symbol: MT2A
Name: metallothionein 1H
RGD ID: 12276421
Description: ENCODES a protein that exhibits cadmium ion binding (ortholog); zinc ion binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cellular response to erythropoietin (ortholog); cellular response to interleukin-3 (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH mercury dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metallothionein 2A; metallothionein-2; metallothionein-II; MT-2; MT-II; MT1H; MT2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,607,926 - 59,608,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,607,927 - 59,626,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,241,670 - 56,242,569 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,152,672 - 60,153,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,152,673 - 60,154,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,983,370 - 56,984,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,992,082 - 57,992,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,885,225 - 58,886,124 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISS)
nucleus  (IBA,ISS)

Molecular Function

References
Additional References at PubMed
PMID:4062298   PMID:10964405   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,607,926 - 59,608,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,607,927 - 59,626,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,241,670 - 56,242,569 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,152,672 - 60,153,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,152,673 - 60,154,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,983,370 - 56,984,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,992,082 - 57,992,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,885,225 - 58,886,124 (-)NCBIUU_Cfam_GSD_1.0
MT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,608,584 - 56,609,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,608,584 - 56,609,497 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,642,496 - 56,643,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,200,012 - 55,200,896 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,200,011 - 55,200,892NCBI
Celera1641,139,964 - 41,140,895 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,512,001 - 42,512,932 (+)NCBIHuRef
CHM1_11658,048,948 - 58,049,879 (+)NCBICHM1_1
T2T-CHM13v2.01662,403,549 - 62,404,462 (+)NCBIT2T-CHM13v2.0
Mt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,899,246 - 94,900,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,899,292 - 94,900,196 (+)EnsemblGRCm39 Ensembl
GRCm38894,172,618 - 94,173,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,172,664 - 94,173,568 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,696,518 - 96,697,467 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,061,913 - 97,062,691 (+)NCBIMGSCv36mm8
Celera898,504,546 - 98,505,495 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.32NCBI
Mt2A
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,837,934 - 10,838,708 (-)NCBIGRCr8
mRatBN7.21910,832,009 - 10,832,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,832,002 - 10,832,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,800,149 - 10,800,923 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,567,003 - 11,567,777 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,853,995 - 10,854,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,307,966 - 11,308,740 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,307,967 - 11,308,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,283,093 - 11,283,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,267,811 - 11,268,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1910,717,971 - 10,718,745 (-)NCBICelera
Cytogenetic Map19p12NCBI
LOC100986475
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,090,308 - 66,091,276 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,009,207 - 72,010,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,894,853 - 36,895,826 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,027,016 - 56,028,093 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,007,922 - 56,028,093 (+)Ensemblpanpan1.1panPan2
MT-2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,645,153 - 18,646,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,645,125 - 18,646,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,420,815 - 26,421,706 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in MT2A
17 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000014487   ⟹   ENSCAFP00000013399
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl259,607,927 - 59,626,727 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006908   ⟹   ENSCAFP00845005503
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,152,673 - 60,154,757 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006916   ⟹   ENSCAFP00845005508
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,152,674 - 60,153,629 (-)Ensembl
RefSeq Acc Id: NM_001003149   ⟹   NP_001003149
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1259,607,926 - 59,608,825 (-)NCBI
Dog10K_Boxer_Tasha256,241,670 - 56,242,569 (-)NCBI
ROS_Cfam_1.0260,152,672 - 60,153,617 (-)NCBI
UMICH_Zoey_3.1256,983,370 - 56,984,269 (-)NCBI
UNSW_CanFamBas_1.0257,992,082 - 57,992,981 (-)NCBI
UU_Cfam_GSD_1.0258,885,225 - 58,886,124 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001003149   ⟸   NM_001003149
- UniProtKB: Q9XST5 (UniProtKB/Swiss-Prot),   A0A8C0JZD1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000013399   ⟸   ENSCAFT00000014487
Ensembl Acc Id: ENSCAFP00845005503   ⟸   ENSCAFT00845006908
Ensembl Acc Id: ENSCAFP00845005508   ⟸   ENSCAFT00845006916

Promoters
RGD ID:13682516
Promoter ID:EPDNEW_C586
Type:multiple initiation site
Name:MT2A_1
Description:Metallothionein-2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1259,608,839 - 59,608,899EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023759 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030004211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040013818 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00845003852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014487.5 UniProtKB/Swiss-Prot
  ENSCAFT00000101165.1 UniProtKB/TrEMBL
  ENSCAFT00030007771.1 UniProtKB/TrEMBL
  ENSCAFT00030007812.1 UniProtKB/Swiss-Prot
  ENSCAFT00040025522.1 UniProtKB/TrEMBL
  ENSCAFT00040025591.1 UniProtKB/Swiss-Prot
  ENSCAFT00845006908.1 UniProtKB/TrEMBL
  ENSCAFT00845006916 ENTREZGENE
  ENSCAFT00845006916.1 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403768 UniProtKB/Swiss-Prot
NCBI Gene MT2A ENTREZGENE
PANTHER METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0JZD1 ENTREZGENE
  A0A8C0M5V6_CANLF UniProtKB/TrEMBL
  A0A8I3MUE5_CANLF UniProtKB/TrEMBL
  MT2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE