ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) - Rat Genome Database

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Gene: ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) Canis lupus familiaris
Analyze
Symbol: ADH4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
RGD ID: 12269874
Description: ENCODES a protein that exhibits alcohol dehydrogenase (NAD+) activity (inferred); aldose reductase (NADPH) activity (inferred); all-trans retinal binding (inferred); INVOLVED IN alcohol catabolic process (ortholog); aldehyde metabolic process (ortholog); ethanol metabolic process (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); autism spectrum disorder (ortholog); Binge Drinking (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alcohol dehydrogenase 4; all-trans-retinol dehydrogenase [NAD(+)] ADH4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,282,526 - 21,299,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,282,890 - 21,299,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,631,099 - 20,647,963 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,468,468 - 21,485,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,468,474 - 21,485,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,433,849 - 21,450,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,260,783 - 21,277,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,617,963 - 18,634,846 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,282,526 - 21,299,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,282,890 - 21,299,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,631,099 - 20,647,963 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,468,468 - 21,485,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,468,474 - 21,485,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,433,849 - 21,450,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,260,783 - 21,277,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,617,963 - 18,634,846 (+)NCBIUU_Cfam_GSD_1.0
ADH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,123,658 - 99,144,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,123,657 - 99,157,792 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,044,809 - 100,065,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,263,855 - 100,284,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,401,812 - 100,423,028NCBI
Celera497,342,359 - 97,362,981 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,782,906 - 95,803,527 (-)NCBIHuRef
CHM1_14100,021,522 - 100,042,141 (-)NCBICHM1_1
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBIT2T-CHM13v2.0
Adh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,121,217 - 138,138,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,121,227 - 138,136,653 (+)EnsemblGRCm39 Ensembl
GRCm383138,415,456 - 138,432,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,415,466 - 138,430,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,078,461 - 138,093,856 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,352,896 - 138,368,279 (+)NCBIMGSCv36mm8
Celera3144,836,181 - 144,853,583 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.24NCBI
Adh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,622,092 - 229,640,120 (+)NCBIGRCr8
mRatBN7.22226,948,717 - 226,966,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,947,466 - 226,987,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,697,253 - 234,715,474 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,596,984 - 232,615,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,461,666 - 227,479,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,702,035 - 243,720,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,700,784 - 243,740,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,237,059 - 262,254,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,952,313 - 235,970,671 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,939,028 - 235,957,343 (+)NCBI
Celera2219,105,553 - 219,122,791 (+)NCBICelera
Cytogenetic Map2q44NCBI
ADH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2397,188,649 - 97,209,293 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,464,601 - 97,485,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,522,444 - 91,543,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14102,186,670 - 102,206,923 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,183,956 - 102,206,923 (-)Ensemblpanpan1.1panPan2
ADH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,225,656 - 121,261,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,225,485 - 121,259,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,582,002 - 98,583,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,409,996 - 130,434,606 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,226,787 - 47,248,518 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,226,191 - 47,248,234 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603725,658,415 - 25,678,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ADH4
235 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000046799   ⟹   ENSCAFP00000041531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3221,282,890 - 21,299,328 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845042716   ⟹   ENSCAFP00845033492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3221,468,474 - 21,485,323 (-)Ensembl
RefSeq Acc Id: XM_038444215   ⟹   XP_038300143
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03221,468,468 - 21,485,373 (-)NCBI
RefSeq Acc Id: XM_038518610   ⟹   XP_038374538
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13221,433,849 - 21,450,220 (-)NCBI
RefSeq Acc Id: XM_038582058   ⟹   XP_038437986
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03218,617,963 - 18,634,846 (+)NCBI
RefSeq Acc Id: XM_038646555   ⟹   XP_038502483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03221,260,783 - 21,277,661 (-)NCBI
RefSeq Acc Id: XM_535665   ⟹   XP_535665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13221,282,526 - 21,299,387 (-)NCBI
Dog10K_Boxer_Tasha3220,631,099 - 20,647,963 (+)NCBI
Sequence:
RefSeq Acc Id: XP_535665   ⟸   XM_535665
- UniProtKB: A0A8C0JRG9 (UniProtKB/TrEMBL),   A0A8C0P4S6 (UniProtKB/TrEMBL),   A0A8I3PLN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000041531   ⟸   ENSCAFT00000046799
RefSeq Acc Id: XP_038374538   ⟸   XM_038518610
RefSeq Acc Id: XP_038502483   ⟸   XM_038646555
RefSeq Acc Id: XP_038300143   ⟸   XM_038444215
- UniProtKB: A0A8C0JRG9 (UniProtKB/TrEMBL),   A0A8C0P4S6 (UniProtKB/TrEMBL),   A0A8I3PLN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437986   ⟸   XM_038582058
- UniProtKB: A0A8C0JRG9 (UniProtKB/TrEMBL),   A0A8C0P4S6 (UniProtKB/TrEMBL),   A0A8I3PLN9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845033492   ⟸   ENSCAFT00845042716
Protein Domains
Enoyl reductase (ER)

Promoters
RGD ID:13688724
Promoter ID:EPDNEW_C6790
Type:initiation region
Name:ADH4_1
Description:alcohol dehydrogenase 4 , pi polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13221,299,300 - 21,299,360EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031667 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022667 UniProtKB/TrEMBL
  ENSCAFG00040021597 UniProtKB/TrEMBL
  ENSCAFG00845024170 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046799.3 UniProtKB/TrEMBL
  ENSCAFT00030041652.1 UniProtKB/TrEMBL
  ENSCAFT00040040084.1 UniProtKB/TrEMBL
  ENSCAFT00845042716 ENTREZGENE
  ENSCAFT00845042716.1 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_C UniProtKB/TrEMBL
  ADH_N UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
KEGG Report cfa:478487 UniProtKB/TrEMBL
NCBI Gene ADH4 ENTREZGENE
PANTHER ALCOHOL DEHYDROGENASE UniProtKB/TrEMBL
  PTHR43880:SF14 UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
PROSITE ADH_ZINC UniProtKB/TrEMBL
SMART PKS_ER UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8C0JRG9 ENTREZGENE
  A0A8C0P4S6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PLN9 ENTREZGENE, UniProtKB/TrEMBL