TLR4 (toll like receptor 4) - Rat Genome Database

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Gene: TLR4 (toll like receptor 4) Canis lupus familiaris
Analyze
Symbol: TLR4
Name: toll like receptor 4
RGD ID: 12269767
Description: ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); astrocyte development (ortholog); B cell proliferation (ortholog); PARTICIPATES IN titanium dioxide nanoparticle response pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH Acanthamoeba Keratitis (ortholog); Acne Conglobata (ortholog); Acute Coronary Syndrome (ortholog); FOUND IN cell surface (ortholog); endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: toll-like receptor 4; Toll-like receptor4 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (ISO)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
acute pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (ISO)
Fungal Keratitis  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
learning disability  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
Ocular Onchocerciasis  (ISO)
Optic Nerve Injuries  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pulpitis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
severe COVID-19  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
sporotrichosis  (ISO)
squamous cell carcinoma  (ISO)
Stable Angina  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA,ISO)
astrocyte development  (IEA,ISO)
B cell proliferation  (IEA,ISO)
B cell proliferation involved in immune response  (IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA)
cellular response to platelet-derived growth factor stimulus  (IEA)
cellular response to retinoic acid  (ISO)
cellular response to type II interferon  (IEA)
defense response to bacterium  (IEA)
defense response to Gram-negative bacterium  (IBA,IEA,ISO)
detection of lipopolysaccharide  (IBA,IEA)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
gene expression  (IEA,ISO)
I-kappaB phosphorylation  (ISO)
immune response  (IEA)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IEA)
innate immune response-activating signaling pathway  (ISO)
intestinal epithelial structure maintenance  (IEA)
JNK cascade  (IEA,ISO)
leukotriene metabolic process  (ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lymphocyte proliferation  (IEA,ISO)
macrophage activation  (IEA)
MHC class II biosynthetic process  (IEA,ISO)
microglia differentiation  (IEA,ISO)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IBA,IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of interleukin-17 production  (IEA)
negative regulation of interleukin-23 production  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of tumor necrosis factor production  (IEA)
negative regulation of type II interferon production  (IEA)
neurogenesis  (IEA,ISO)
nitric oxide biosynthetic process  (IEA,ISO)
nitric oxide production involved in inflammatory response  (IEA,ISO)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
phagocytosis  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-1 production  (IEA)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA,ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of matrix metallopeptidase secretion  (IEA)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of platelet activation  (IEA)
positive regulation of reactive oxygen species biosynthetic process  (IEA)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of stress-activated MAPK cascade  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA)
regulation of dendritic cell cytokine production  (IEA,ISO)
regulation of inflammatory response  (IEA)
regulation of tumor necrosis factor production  (ISO)
response to activity  (ISO)
response to bacterium  (IEA,ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to gold nanoparticle  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to oxidative stress  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to toxic substance  (ISO)
signal transduction  (IEA)
skeletal muscle contraction  (ISO)
stress-activated MAPK cascade  (IEA,ISO)
toll-like receptor 4 signaling pathway  (IBA,IEA,ISO)
toll-like receptor signaling pathway  (IEA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA)
wound healing involved in inflammatory response  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14592729   PMID:15375763   PMID:20519082   PMID:20594076   PMID:21203467   PMID:21752456   PMID:22301074   PMID:25266752   PMID:25283216   PMID:30032202   PMID:30947975  


Genomics

Comparative Map Data
TLR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBIUU_Cfam_GSD_1.0
TLR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9117,704,175 - 117,724,735 (+)EnsemblGRCh38hg38GRCh38
GRCh379120,466,681 - 120,487,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36Build 36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
T2T-CHM13v2.09129,898,286 - 129,918,621 (+)NCBIT2T-CHM13v2.0
Tlr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)EnsemblGRCm39 Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBIMGSCv36mm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
Tlr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
Tlr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
TLR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21121,637,696 - 21,650,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1921,630,343 - 21,652,922 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0988,827,495 - 88,840,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19117,180,250 - 117,193,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9117,180,550 - 117,190,711 (+)Ensemblpanpan1.1panPan2
Tlr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947186,750,688 - 186,763,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364876,518,441 - 6,533,095 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364876,519,140 - 6,532,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,044,610 - 258,058,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,044,610 - 258,054,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21289,775,816 - 289,785,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11221,873,762 - 21,885,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1221,871,773 - 21,885,515 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603521,002,852 - 21,019,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476017,598,630 - 17,609,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476017,596,516 - 17,608,955 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TLR4
121 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000005653   ⟹   ENSCAFP00000031395
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845021383   ⟹   ENSCAFP00845016810
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845021396   ⟹   ENSCAFP00845016818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1172,483,456 - 72,494,267 (+)Ensembl
RefSeq Acc Id: NM_001002950   ⟹   NP_001002950
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11171,356,390 - 71,367,166 (+)NCBI
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBI
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBI
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBI
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBI
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002950 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB85609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000031395.3
  ENSCAFP00000071026.1
  ENSCAFP00030025106.1
  ENSCAFP00040014789.1
  ENSCAFP00845016810.1
  ENSCAFP00845016818.1
RefSeq Acc Id: NP_001002950   ⟸   NM_001002950
- Peptide Label: precursor
- UniProtKB: A0A8C0NHG9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000031395   ⟸   ENSCAFT00000005653
Ensembl Acc Id: ENSCAFP00845016810   ⟸   ENSCAFT00845021383
Ensembl Acc Id: ENSCAFP00845016818   ⟸   ENSCAFT00845021396
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003518 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015628 UniProtKB/TrEMBL
  ENSCAFG00040009188 UniProtKB/TrEMBL
  ENSCAFG00845012026 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005653.5 UniProtKB/TrEMBL
  ENSCAFT00000105008.1 UniProtKB/TrEMBL
  ENSCAFT00030028800.1 UniProtKB/TrEMBL
  ENSCAFT00040017064.1 UniProtKB/TrEMBL
  ENSCAFT00845021383.1 UniProtKB/TrEMBL
  ENSCAFT00845021396.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_4 UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:403417 UniProtKB/TrEMBL
NCBI Gene TLR4 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 4 UniProtKB/TrEMBL
Pfam LRR_4 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A0A8C0NHG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YS26_CANLF UniProtKB/TrEMBL
  A0A8I3RZ33_CANLF UniProtKB/TrEMBL
  A0A8P0NLR5_CANLF UniProtKB/TrEMBL
  Q8SQH3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:51765 ENTREZGENE