CYP11B1 (cytochrome P450 family 11 subfamily B member 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CYP11B1 (cytochrome P450 family 11 subfamily B member 1) Canis lupus familiaris
Analyze
Symbol: CYP11B1
Name: cytochrome P450 family 11 subfamily B member 1
RGD ID: 12259565
Description: ENCODES a protein that exhibits corticosterone 18-monooxygenase activity (ortholog); steroid 11-beta-monooxygenase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); aldosterone biosynthetic process (ortholog); C21-steroid hormone biosynthetic process (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH adrenal cortical adenoma (ortholog); autism spectrum disorder (ortholog); Congenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CYP11B2; cytochrome P450 11B1, mitochondrial; cytochrome P450, family 11, subfamily B, polypeptide 2; mitochondrial cytochrome P450 11B2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,866,476 - 36,880,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,823,864 - 36,833,784 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,342,302 - 37,352,691 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11337,015,530 - 37,025,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,134,290 - 37,144,097 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,610,637 - 37,619,980 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP11B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,866,476 - 36,880,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,823,864 - 36,833,784 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,342,302 - 37,352,691 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11337,015,530 - 37,025,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,134,290 - 37,144,097 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,610,637 - 37,619,980 (+)NCBIUU_Cfam_GSD_1.0
CYP11B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,910,559 - 142,917,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,910,559 - 142,917,843 (-)EnsemblGRCh38hg38GRCh38
GRCh378143,991,975 - 143,999,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,988,977 - 143,996,261 (-)NCBINCBI36Build 36hg18NCBI36
Build 348143,988,976 - 143,996,261NCBI
Celera8140,301,421 - 140,308,694 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,244,244 - 139,251,515 (-)NCBIHuRef
CHM1_18144,032,236 - 144,039,525 (-)NCBICHM1_1
T2T-CHM13v2.08144,053,900 - 144,061,172 (-)NCBIT2T-CHM13v2.0
Cyp11b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,722,467 - 74,728,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1574,722,467 - 74,728,167 (-)EnsemblGRCm39 Ensembl
GRCm381574,850,618 - 74,856,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,851,010 - 74,856,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,681,440 - 74,686,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361574,678,294 - 74,683,480 (-)NCBIMGSCv36mm8
Celera1576,357,529 - 76,362,843 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
Cyp11b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,689,319 - 108,694,808 (-)NCBIGRCr8
mRatBN7.27106,808,559 - 106,814,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,808,559 - 106,814,048 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,534,544 - 108,540,024 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,758,218 - 110,763,690 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,704,151 - 110,709,631 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,155,928 - 116,161,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,059,008 - 116,064,497 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,013,335 - 113,018,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,047,564 - 113,053,054 (-)NCBI
Celera7103,180,975 - 103,186,464 (-)NCBICelera
Cytogenetic Map7q34NCBI
CYP11B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,346,798 - 160,354,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,873,004 - 135,880,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,622,632 - 139,630,014 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,666,534 - 142,672,575 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,666,534 - 142,672,575 (-)Ensemblpanpan1.1panPan2
CYP11B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.141,365,725 - 1,373,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC101700701
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,701,382 - 13,708,750 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CYP11B1
381 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022426825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038555706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038555707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038555708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_539192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ195094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_038429457   ⟹   XP_038285385
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,823,880 - 36,833,784 (+)NCBI
RefSeq Acc Id: XM_038429460   ⟹   XP_038285388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,823,864 - 36,833,784 (+)NCBI
RefSeq Acc Id: XM_038429465   ⟹   XP_038285393
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1336,823,882 - 36,833,784 (+)NCBI
RefSeq Acc Id: XM_038493411   ⟹   XP_038349339
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11337,015,530 - 37,025,564 (+)NCBI
RefSeq Acc Id: XM_038555706   ⟹   XP_038411634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01337,610,648 - 37,619,980 (+)NCBI
RefSeq Acc Id: XM_038555707   ⟹   XP_038411635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01337,610,637 - 37,619,980 (+)NCBI
RefSeq Acc Id: XM_038555708   ⟹   XP_038411636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01337,610,648 - 37,619,980 (+)NCBI
RefSeq Acc Id: XM_038619612   ⟹   XP_038475540
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01337,134,327 - 37,144,097 (+)NCBI
RefSeq Acc Id: XM_038619613   ⟹   XP_038475541
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01337,134,290 - 37,144,097 (+)NCBI
RefSeq Acc Id: XM_038619614   ⟹   XP_038475542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01337,134,330 - 37,144,097 (+)NCBI
RefSeq Acc Id: XM_038685225   ⟹   XP_038541153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,342,316 - 37,352,691 (+)NCBI
RefSeq Acc Id: XM_038685226   ⟹   XP_038541154
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,342,302 - 37,352,691 (+)NCBI
RefSeq Acc Id: XM_038685227   ⟹   XP_038541155
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01337,342,318 - 37,352,691 (+)NCBI
RefSeq Acc Id: XP_038349339   ⟸   XM_038493411
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475541   ⟸   XM_038619613
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038475540   ⟸   XM_038619612
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475542   ⟸   XM_038619614
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038541154   ⟸   XM_038685226
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L1P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541153   ⟸   XM_038685225
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P9U3 (UniProtKB/TrEMBL),   A0A8C0L1P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541155   ⟸   XM_038685227
- Peptide Label: isoform X3
- UniProtKB: A0A8C0PK35 (UniProtKB/TrEMBL),   A0A8C0L1P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038285388   ⟸   XM_038429460
- Peptide Label: isoform X2
- UniProtKB: A0A8I3RY53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038285385   ⟸   XM_038429457
- Peptide Label: isoform X1
- UniProtKB: A0A8P0P1L3 (UniProtKB/TrEMBL),   A0A8I3RY53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038285393   ⟸   XM_038429465
- Peptide Label: isoform X3
- UniProtKB: A0A8I3RY53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411635   ⟸   XM_038555707
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L1P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411634   ⟸   XM_038555706
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L1P2 (UniProtKB/TrEMBL),   A0A8C0P9U3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411636   ⟸   XM_038555708
- Peptide Label: isoform X3
- UniProtKB: A0A8C0L1P2 (UniProtKB/TrEMBL),   A0A8C0PK35 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001285 UniProtKB/TrEMBL
  ENSCAFG00030023419 UniProtKB/TrEMBL
  ENSCAFG00845014518 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000089433.2 UniProtKB/TrEMBL
  ENSCAFT00030043321.1 UniProtKB/TrEMBL
  ENSCAFT00030043349.1 UniProtKB/TrEMBL
  ENSCAFT00030043365.1 UniProtKB/TrEMBL
  ENSCAFT00845025966.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_mitochondrial UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene CYP11B2 ENTREZGENE
PANTHER CYTOCHROME P450 11B2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR24279 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS MITP450 UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C0L1P2 ENTREZGENE
  A0A8C0P9U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PK35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RY53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P1L3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111833 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-26 CYP11B1  cytochrome P450 family 11 subfamily B member 1  CYP11B2  cytochrome P450, family 11, subfamily B, polypeptide 2  Symbol and/or name change 19259463 PROVISIONAL