PRSS57 (serine protease 57) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: PRSS57 (serine protease 57) Canis lupus familiaris
Analyze
Symbol: PRSS57
Name: serine protease 57
RGD ID: 12250550
Description: ENCODES a protein that exhibits heparin binding (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); COVID-19 (ortholog); cyclic hematopoiesis (ortholog); FOUND IN azurophil granule lumen (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protease, serine 57; protease, serine-like 1; PRSSL1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,873,891 - 57,877,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,874,770 - 57,877,888 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,676,792 - 57,680,073 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,617,342 - 58,620,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,617,180 - 58,620,630 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,671,521 - 57,674,808 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,151,008 - 58,154,302 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,354,352 - 58,357,640 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PRSS57
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,873,891 - 57,877,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,874,770 - 57,877,888 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,676,792 - 57,680,073 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,617,342 - 58,620,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,617,180 - 58,620,630 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,671,521 - 57,674,808 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,151,008 - 58,154,302 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,354,352 - 58,357,640 (+)NCBIUU_Cfam_GSD_1.0
PRSS57
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819685,546 - 695,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19685,546 - 695,498 (-)EnsemblGRCh38hg38GRCh38
GRCh3719685,546 - 695,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619636,546 - 646,461 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419636,545 - 646,461NCBI
Celera19120,996 - 132,062 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19455,352 - 465,453 (-)NCBIHuRef
CHM1_119685,251 - 695,165 (-)NCBICHM1_1
T2T-CHM13v2.019639,634 - 649,468 (-)NCBIT2T-CHM13v2.0
Prss57
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,617,308 - 79,630,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,617,308 - 79,626,795 (-)EnsemblGRCm39 Ensembl
GRCm381079,781,474 - 79,794,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,781,474 - 79,790,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,244,219 - 79,251,730 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,244,219 - 79,251,730 (-)NCBIMGSCv36mm8
Celera1080,796,169 - 80,803,685 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Prss57
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,563,477 - 10,573,617 (+)NCBIGRCr8
mRatBN7.279,915,667 - 9,922,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,917,484 - 9,922,922 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,798,509 - 12,803,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,676,590 - 14,681,950 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,535,791 - 12,541,268 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,798,310 - 12,804,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,798,868 - 12,804,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,968,017 - 12,975,388 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,431,197 - 11,436,541 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,431,196 - 11,436,541 (+)NCBI
Celera78,091,033 - 8,096,377 (+)NCBICelera
Cytogenetic Map7q11NCBI
Prss57
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554957,067,844 - 7,077,048 (+)NCBIChiLan1.0ChiLan1.0
PRSS57
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,009,782 - 5,027,487 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,246,843 - 4,265,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019440,415 - 452,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119650,617 - 652,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PRSS57
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,650,879 - 77,655,712 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,649,741 - 77,657,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2278,325,996 - 78,327,174 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS57
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16443,859 - 449,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6444,098 - 449,152 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,505,941 - 8,511,532 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in PRSS57
107 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000031333   ⟹   ENSCAFP00000029162
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2057,874,770 - 57,877,888 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845026345   ⟹   ENSCAFP00845020770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2058,617,180 - 58,620,630 (+)Ensembl
RefSeq Acc Id: XM_038429375   ⟹   XP_038285303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02058,617,342 - 58,620,632 (+)NCBI
RefSeq Acc Id: XM_038504900   ⟹   XP_038360828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12057,671,521 - 57,674,808 (+)NCBI
RefSeq Acc Id: XM_038568058   ⟹   XP_038423986
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02058,354,352 - 58,357,640 (+)NCBI
RefSeq Acc Id: XM_038632167   ⟹   XP_038488095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02058,151,008 - 58,154,302 (+)NCBI
RefSeq Acc Id: XM_542217   ⟹   XP_542217
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12057,873,891 - 57,877,890 (+)NCBI
Dog10K_Boxer_Tasha2057,676,792 - 57,680,073 (+)NCBI
Sequence:
RefSeq Acc Id: XP_542217   ⟸   XM_542217
- UniProtKB: A0A8C0NW45 (UniProtKB/TrEMBL),   A0A8C0KSH4 (UniProtKB/TrEMBL),   A0A8I3RYB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000029162   ⟸   ENSCAFT00000031333
RefSeq Acc Id: XP_038360828   ⟸   XM_038504900
RefSeq Acc Id: XP_038488095   ⟸   XM_038632167
RefSeq Acc Id: XP_038285303   ⟸   XM_038429375
- UniProtKB: A0A8C0NW45 (UniProtKB/TrEMBL),   A0A8C0KSH4 (UniProtKB/TrEMBL),   A0A8I3RYB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423986   ⟸   XM_038568058
- UniProtKB: A0A8C0KSH4 (UniProtKB/TrEMBL),   A0A8C0NW45 (UniProtKB/TrEMBL),   A0A8I3RYB9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845020770   ⟸   ENSCAFT00845026345
Protein Domains
Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019702 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030020040 UniProtKB/TrEMBL
  ENSCAFG00040011141 UniProtKB/TrEMBL
  ENSCAFG00845014740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031333.5 UniProtKB/TrEMBL
  ENSCAFT00030036826.1 UniProtKB/TrEMBL
  ENSCAFT00040020592.1 UniProtKB/TrEMBL
  ENSCAFT00845026345 ENTREZGENE
  ENSCAFT00845026345.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
NCBI Gene PRSS57 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/TrEMBL
  SERINE PROTEASE 57 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A8C0KSH4 ENTREZGENE
  A0A8C0NW45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RYB9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54343 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-23 PRSS57  serine protease 57    protease, serine 57  Symbol and/or name change 5135510 APPROVED