Advanced Search (OLGA)

Gene: TOP2A (DNA topoisomerase II alpha) Canis lupus familiaris

Analyze

Symbol:

TOP2A

Name:

DNA topoisomerase II alpha

RGD ID:

12233742

Description:

ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN cerebellar granule cell differentiation (ortholog); cerebellar Purkinje cell differentiation (ortholog); chromosome condensation (ortholog); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (ortholog); nucleolus (ortholog); INTERACTS WITH bisphenol A

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 2-alpha; topoisomerase (DNA) II alpha; topoisomerase (DNA) II alpha 170kDa

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOP2A (DNA topoisomerase II alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Top2a (topoisomerase (DNA) II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Top2a (DNA topoisomerase II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Top2a (DNA topoisomerase II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOP2A (DNA topoisomerase II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Top2a (DNA topoisomerase II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TOP2A (DNA topoisomerase II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TOP2A (DNA topoisomerase II alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	22,207,501 - 22,237,497 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	22,207,638 - 22,237,496 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	21,679,941 - 21,709,943 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	23,000,244 - 23,030,254 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	23,000,269 - 23,029,980 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	21,774,298 - 21,804,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	22,033,150 - 22,063,078 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	22,157,897 - 22,187,909 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute promyelocytic leukemia (ISO)

adenoid cystic carcinoma (ISO)

adrenocortical carcinoma (ISO)

Animal Disease Models (ISO)

Breast Neoplasms (ISO)

cervix uteri carcinoma in situ (ISO)

COVID-19 (ISO)

Disease Progression (ISO)

ductal carcinoma in situ (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

Kidney Neoplasms (ISO)

leukemia (ISO)

Liver Neoplasms (ISO)

long QT syndrome (ISO)

lung adenocarcinoma (ISO)

nephroblastoma (ISO)

Ovarian Neoplasms (ISO)

penile benign neoplasm (ISO)

polycystic ovary syndrome (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

Recurrence (ISO)

Salivary Gland Neoplasms (ISO)

Sepsis (ISO)

urinary bladder cancer (ISO)

Uterine Cervical Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

bisphenol A (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic chromosome condensation (IBA,IEA)

cerebellar granule cell differentiation (ISO)

cerebellar Purkinje cell differentiation (ISO)

chromatin organization (IEA)

chromosome condensation (IEA,ISO)

chromosome segregation (IEA,ISO)

DNA damage response (IEA)

DNA topological change (IEA,ISO)

embryonic cleavage (IEA,ISO)

female meiotic nuclear division (IEA)

hematopoietic progenitor cell differentiation (IEA,ISO)

positive regulation of apoptotic process (IEA)

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of circadian rhythm (IEA)

resolution of meiotic recombination intermediates (IBA)

response to ionizing radiation (ISO)

response to parathyroid hormone (ISO)

response to xenobiotic stimulus (ISO)

rhythmic process (IEA)

sister chromatid segregation (IBA)

Cellular Component

centriole (IEA)

chromosome, centromeric region (IEA)

condensed chromosome (IEA)

cytoplasm (IEA)

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (IEA,ISO)

male germ cell nucleus (IEA)

nuclear chromosome (IEA)

nucleolus (IEA,ISO)

nucleoplasm (IEA)

nucleus (IBA,IEA)

protein-containing complex (IEA)

ribonucleoprotein complex (IEA)

Molecular Function

ATP binding (IEA,ISO)

ATP-dependent activity, acting on DNA (IEA)

chromatin binding (IEA,ISO)

DNA binding (IEA,ISO)

DNA binding, bending (IEA)

DNA topoisomerase activity (IEA,ISO)

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (IEA,ISO)

magnesium ion binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

protein homodimerization activity (IEA)

protein kinase C binding (IEA)

sequence-specific DNA binding (ISO)

ubiquitin binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

doxorubicin pharmacodynamics pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

teniposide pharmacodynamics pathway (ISO)

teniposide pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202	PMID:37175843

Genomics

Comparative Map Data

TOP2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	22,207,501 - 22,237,497 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	22,207,638 - 22,237,496 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	21,679,941 - 21,709,943 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	23,000,244 - 23,030,254 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	23,000,269 - 23,029,980 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	21,774,298 - 21,804,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	22,033,150 - 22,063,078 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	22,157,897 - 22,187,909 (+)	NCBI		UU_Cfam_GSD_1.0

TOP2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	40,388,525 - 40,417,896 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	40,388,525 - 40,417,896 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	38,544,777 - 38,574,148 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	35,798,321 - 35,827,695 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	35,798,320 - 35,827,695	NCBI
Celera	17	35,204,916 - 35,234,352 (-)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	34,337,633 - 34,367,123 (-)	NCBI		HuRef
CHM1_1	17	38,780,085 - 38,809,522 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	41,252,019 - 41,281,395 (-)	NCBI		T2T-CHM13v2.0

Top2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	98,883,773 - 98,915,037 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	98,883,769 - 98,915,015 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	98,992,947 - 99,024,199 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	98,992,943 - 99,024,189 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	98,854,261 - 98,885,503 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	98,809,493 - 98,840,205 (-)	NCBI		MGSCv36	mm8
Celera	11	108,658,802 - 108,690,006 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	62.91	NCBI

Top2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	84,441,954 - 84,473,093 (-)	NCBI		GRCr8
mRatBN7.2	10	83,945,731 - 83,976,874 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	83,945,735 - 83,976,874 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	88,889,659 - 88,920,792 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	88,387,764 - 88,418,905 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	83,780,312 - 83,811,315 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	86,901,467 - 86,930,947 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	86,901,007 - 86,932,154 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	86,699,277 - 86,728,310 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	87,771,337 - 87,800,960 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	87,785,706 - 87,815,332 (-)	NCBI
Celera	10	82,687,594 - 82,716,976 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Top2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	14,929,136 - 14,964,723 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	14,928,273 - 14,964,855 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOP2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	24,537,882 - 24,567,338 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	26,432,885 - 26,462,340 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	16,872,169 - 16,901,605 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	17,097,619 - 17,127,195 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	17,097,778 - 17,126,207 (+)	Ensembl	panpan1.1		panPan2

Top2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	21,608,163 - 21,633,139 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	15,441,575 - 15,466,978 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	15,441,463 - 15,465,692 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	22,001,282 - 22,028,450 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	22,001,300 - 22,028,452 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	22,310,214 - 22,337,485 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOP2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	65,761,391 - 65,792,041 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	65,761,416 - 65,792,701 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	36,662,555 - 36,693,082 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in TOP2A
253 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038485611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038485612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038547378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038603195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038611361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038611362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038676553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038676554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_537646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000025539 ⟹ ENSCAFP00000023713

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	22,207,638 - 22,237,496 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000046104 ⟹ ENSCAFP00000042966

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	22,207,842 - 22,237,496 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845014593 ⟹ ENSCAFP00845011307

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	23,000,269 - 23,029,980 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845014679 ⟹ ENSCAFP00845011373

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	23,000,269 - 23,029,980 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845014873 ⟹ ENSCAFP00845011528

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	23,000,585 - 23,029,980 (+)	Ensembl

RefSeq Acc Id:

XM_038485611 ⟹ XP_038341539

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	21,774,624 - 21,804,337 (+)	NCBI

RefSeq Acc Id:

XM_038485612 ⟹ XP_038341540

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	21,774,298 - 21,804,337 (+)	NCBI

RefSeq Acc Id:

XM_038547378 ⟹ XP_038403306

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	9	22,157,897 - 22,187,909 (+)	NCBI

RefSeq Acc Id:

XM_038603195 ⟹ XP_038459123

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	9	21,680,267 - 21,709,943 (+)	NCBI

RefSeq Acc Id:

XM_038611361 ⟹ XP_038467289

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	22,033,476 - 22,063,078 (+)	NCBI

RefSeq Acc Id:

XM_038611362 ⟹ XP_038467290

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	22,033,150 - 22,063,078 (+)	NCBI

RefSeq Acc Id:

XM_038676553 ⟹ XP_038532481

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	23,000,570 - 23,030,254 (+)	NCBI

RefSeq Acc Id:

XM_038676554 ⟹ XP_038532482

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	23,000,244 - 23,030,254 (+)	NCBI

RefSeq Acc Id:

XM_537646 ⟹ XP_537646

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	22,207,501 - 22,237,497 (+)	NCBI
Dog10K_Boxer_Tasha	9	21,679,941 - 21,709,943 (+)	NCBI

Sequence:

show sequence

GGGAGGTTCAAACGCGACTGGAGGAGCTCTTCTAACCGACGGGAGTCTGTGGAGAAGAGGCTCG
CTCCGTGGTGGTCTCGGGGGTCCTGCCGGTTTAGTCGCTTGCAGGGTTCTCGAGCTCCTTCACG
ACCGTCACCATGGAGGTGTCACCACTGCAGCCGGTAAATGAAAACATGCAAATCAGCAAAACAA
AGAAAAATGAAGATGCTAAGAAAAGACTGTCTATTGAAAGGATCTATCAAAAGAAAACCCAACT
GGAACATATTTTGCTCCGCCCGGACACCTACATTGGCTCTGTGGAATTAGTGACCCAGCAAATG
TGGGTTTACGATGAAGATATTGGCATGAACTATAGGGAAGTCACCTTTGTCCCTGGGTTGTACA
AAATCTTTGATGAGATTCTGGTCAATGCTGCAGACAACAAACAAAGGGACCCAAAAATGTCTTG
TATTAGAGTCACAATTGACCCGGAAAACAATTTAATTAGTATATGGAATAATGGGAAAGGTATT
CCTGTTGTTGAACACAAAGTTGAGAAGATGTATGTCCCAGCACTCATCTTTGGACAGCTCCTAA
CTTCTAGTAACTATGATGATGATGAAAAGAAAGTAACAGGTGGTCGAAATGGCTATGGGGCCAA
ATTGTGTAACATATTCAGTACCAAGTTTACTGTGGAAACAGCCAGTAGAGAATACAAGAAAATG
TTCAAACAGACGTGGATGGATAACATGGGAAGGGCTGGTGAGATGGAACTCAGGCCATTTAATG
GGGAAGATTATACATGTATTACCTTCCAGCCTGACTTGTCCAAGTTTAAAATGCAAAGCCTAGA
TAAAGACATTGTTGCACTGATGGTTAGAAGAGCATACGATATTGCTGGATCCACTAAAGATGTC
AAAGTCTTTCTCAATGGAAATAAACTACCAGTAAAAGGATTCCGTAGCTACGTAGATATGTATC
TGAAGGATAAGGTAGATGAAACTGGCAATCCATTGAAAATTATCCATGAACAAGTAAACCCCAG
GTGGGAAGTATGTTTAACAATGAGTGAAAAAGGCTTTCAGCAAATTAGCTTCGTCAACAGCATT
GCTACCTCCAAGGGTGGCAGACATGTTGATTATATAGCTGATCAGATTGTGACTAAACTTGTTG
ATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACAT
GTGGATTTTTGTGAATGCCTTGATTGAAAACCCAACCTTTGACTCTCAGACGAAAGAAAACATG
ACTTTACAAGTCAAGAGCTTTGGATCAACATGCCAATTAAGTGAAAAATTCATCAAAGCTGCAA
CTGGCTGTGGTATTGTGGAAAGCATTCTAAACTGGGTAAAGTTTAAGGCCCAAATCCAATTAAA
CAAGAAGTGTTCAGCTGTAAAGCATAACAGAATCAAGGGAATTCCCAAACTTGATGATGCCAAT
GACGCAGGGGGTCGAAACTCCAATGAGTGTACACTTATCCTGACTGAAGGAGACTCAGCTAAAA
CTTTGGCTGTTTCAGGCCTTGGTGTGGTTGGGAGAGACAAATATGGAGTTTTCCCACTTAGAGG
AAAAATACTCAATGTTCGAGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATTAATAAT
ATCATCAAGATCGTGGGTCTTCAGTACAAGAAAAACTATGACGATGAAGATTCATTGAAGACTC
TTCGTTATGGGAAGATAATGATTATGACAGATCAGGACCAAGATGGTTCCCATATCAAAGGCTT
GCTGATTAATTTTATCCATCATAACTGGCCCTCTCTTCTACGGCATCGTTTTCTGGAGGAATTT
ATCACTCCGATTGTAAAGGTGTCTAAAAACAAACAAGAAATGGCATTCTATAGCCTTCCTGAAT
TTGAAGAATGGAAGAGTTCTACTCCAAATCATAAAAAATGGAAAGTCAAGTACTACAAAGGTTT
GGGTACCAGCACATCAAAAGAAGCTAAAGAATACTTTGCAAATATGAAAAGACATCGTATTCAG
TTCAAATACTCCGGTCCTGAAGATGATGCTGCCATCAGCTTGGCCTTTAGCAAGAAACAGATAG
ATGATCGAAAGGAATGGTTAACTCATTTCATGGAAGATAGAAGACAACGGAAGTTACTTGGCCT
TCCTGAGGATTACTTGTATGGGCAAACTACCACATATCTGACATACAATGACTTTATAAATAAG
GAACTTATCCTGTTCTCAAATTCTGATAACGAGAGATCTATCCCATCTATGGTGGATGGCTTGA
AACCAGGTCAAAGAAAGGTTTTGTTTACCTGTTTCAAACGGAATGACAAGCGAGAGGTGAAGGT
TGCCCAGTTGGCTGGGTCAGTGGCTGAGATGTCCTCTTATCATCATGGTGAGATGTCACTAATG
ATGACCATTATAAATTTGGCTCAGAATTTTGTGGGTAGCAATAATCTGAACCTCTTGCAGCCCA
TTGGTCAGTTTGGTACTAGGCTGCACGGTGGCAAGGATTCTGCTAGTCCTCGATACATCTTCAC
AATGCTCAGCCCTTTGGCTCGGTTATTGTTTCCACCAAAAGATGATCAGACTTTAAAGTTTTTA
TATGATGACAATCAACGTGTTGAACCTGAATGGTACATTCCCATTATACCCATGGTGCTGATAA
ATGGTGCTGAAGGAATTGGTACTGGGTGGTCCTGCAAAATCCCCAACTTTGATATTCGTGAAGT
TGTAAATAATATCAGGCGTTTGATGGATGGAGAAGAACCTTTGCCAATGCTTCCAAGTTACAAG
AACTTCAGGGGTACTATTGAAGAGCTGGCTCCAAATCAGTATGTGATTAGTGGTGAAGTGGCTA
TACTTAATTCCACAACCATTGAAATCTCAGAGCTTCCTGTCAGAACATGGACCCAGACCTATAA
AGAACAGGTTCTAGAACCCATGTTGAATGGCACTGAGAAGACACCACCTCTCATAACAGATTAT
AGGGAGTACCATACAGACACCACTGTGAAGTTTGTTGTGAAGATGACTGAAGAGAAACTGGCAG
AGGCAGAGAGAGTGGGGCTACACAAAGTCTTCAAACTCCAAACTAGTCTCACATGCAACTCCAT
GGTGCTTTTTGACCATGTAGGTTGTTTAAAGAAATATGACACAGTGTTGGATATTCTAAGAGAC
TTCTTTGAACTAAGGCTTAAATATTATGGATTAAGAAAAGAATGGCTTCTAGGAATGCTTGGCG
CTGAATCTGCTAAACTGAACAATCAGGCTCGCTTTATCTTAGAGAAAATAGATGGCAAAATAAT
TATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATTCGGAT
CCTGTGAAGGCTTGGAAAGAAGCTCAGCAAAAGGTACCAGATGAAGAAGAGAATGAAGAGAGTG
ACAATGAAAATGAAGCTGAAAAGAGTGACTCTGTAAGAGATTCTGGACCAACCTTCAACTACCT
TCTTGATATGCCTCTTTGGTATCTCACCAAGGAGAAGAAGGATGAACTGTGCAAGCTGAGAAAT
GAAAAAGAGCAAGAACTAGAAACATTAAAGAGAAAGAGTCCAACAGATTTGTGGAAAGAAGACT
TGGCTACTTTTGTTGAAGAGCTAGAGGCTGTTGAAACAAAGGAAAAACAAGAAGAACAAATAGG
ACTTCCAGGGAAAGGAGGGAAAGGAAAGGGGAAAAAAACACAAATGGCTGAAGTTTTGCCTTCT
CCTTGCGGAAAAAGAGTCATCCCCCGAGTGACCATAGAGATGAAAGCAGAGGCAGAAAAGAAAA
ATAAAAAGAAAATTAAGAATGAAAACACTGAAGGGAGCCCTCAAGAAGAGAGTATCGAAATAGA
AGGTCTGAAACAAAGGTTGGAGAAGAAACAGAAAAGAGAACCAGGTACCAAGACAAAGAAGCAA
ACTACATTGCCGTTTAAACCCATCAAAAAAGGAAAGAAGAGAAACCCCTGGTCTGATTCAGAAT
CAGATATGAGCAGTAATGAAAGTAACTTTGATGTCCCTCCACGAGAGGTAGAGCCACGGAGAGC
AGCAACAAAAACCAAATTCACAGTGGATTTGGATTTAGACGACAGTTTCTCAGATTTTGAAGAA
AGAATTCAAGATGAGGATTCTGTTCCATCAGATGTCAGCCCACATAAGACCAAAGCTTCCCCAA
AACGTACTGCCAAAGAACTGAAGCCACAGAAAAGTGCCCCCCCAGTAATGGACCTTGATGCTGA
TGATGCCAAGGACAGTGTACCACTTTCTCCAGGTTCTACTGCTGATTTCTTGGCTGAAACTGAA
ATTGTAAACCCCCTTCCTAAAAAGAAGGTGGACGTGAAGAAGATAGCACCAAAAAGTCAGTCTT
CCACCTCCACTACAGGTGCAAAAAAAAGGGCTGCACCAAAAGGAACCAAAAAGGATCCAGGCTT
AAATTCTGATGTCTCTCAAAAGCCTGATCCCCCAAAAACCAAAAATCACCGCAAAAGGAAGCCA
TCCACTTCTGATGATTCCGACTCTAATTTTGAGAAGATGATTTCTAAAGCAGCCACAAACAAGA
AATCCAAGGGGGAGAGTGAAGACTTCCATCTGGACCTAGACTCAGGTGTGGCTCCTCGGGCCAA
ATCTGGACGTGCAAGGAAACCTATAAAGTACCTTGAAGAATCAGATGAAGATGATCTGTTCTAA
AATGTGATTATTTTAAGTAACGGTCTTATCGAGCCCAAGACAGGTTTTAGAATTACCTGAATCC
TTTAATTTCCTCCCCTCTGAATTTTTTTGGGGGGAGATAGTTTTAATTCAGAACCATCAAAGTG
AAGTGTGTAGAGTACAAGTATCTATTACCCTTTTATAATACTGTCCGAATAATGGCCACCTCCT
GGGCATTGTTTTCTTCTCTGCTTTGTCTTTGTTTGGAGTGTCTCTTGTCTTTAGAATCTGATTT
TAAGTTCTTCTGGACTTTGAAGATGGTTGTATGTTCGCTTCGTCATAATATAGCTTATTGACTA
CTCATTAAGCTAAAATTGTAAAAGTGTCTAGTCTACCTCTTTTCCTACTTTCAGTAAATATGAG
ATACCACATGATTAATTCTGTTTTACCTTAGTTTTATAGGTAATTTTCCATCAGATAGAATTTT
ATAGTTCTAGTACAAATACTCCCCACTCAGCCTTTCGTGTGCGGAATTTCTGCTCAAGCATTGA
GAAATTTATCCATTTGAATGTTAGCAGAGGCTGAAGAGAAACAGCCTGGCTATGTTTGTATAGC
CTCAACACAGTCAATAGGGTGAAGAAAATTAGGCCATAAGTTATGGGACTATCTCAATTCTTGA
CTTGTCACCTCGAGCTGTCTCCCAAGTTTGAATCTCCCAAACAACAAATATCTAGGGAGCACTG
GATTGCAGAAAAGTGGGGGGACGGAGAGATCTTATACCAATGCCATCAATACTCAGCAGTGAGT
GGTTATATCCATTTTGGAGAATCTCCATAATTTGCAACTTAGAAGTTTTTTTAAGGCATTTCTG
TGTGTGACTTGATTGGTGTTATCAATGTTTTTGTAAATATTTACTATGTTTTTCTATTTCACTT
AATTCTAACAGTATTTTACTTTAATAAAATGTTCTAAACATTGCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038341539	(Get FASTA)	NCBI Sequence Viewer
	XP_038341540	(Get FASTA)	NCBI Sequence Viewer
	XP_038403306	(Get FASTA)	NCBI Sequence Viewer
	XP_038459123	(Get FASTA)	NCBI Sequence Viewer
	XP_038467289	(Get FASTA)	NCBI Sequence Viewer
	XP_038467290	(Get FASTA)	NCBI Sequence Viewer
	XP_038532481	(Get FASTA)	NCBI Sequence Viewer
	XP_038532482	(Get FASTA)	NCBI Sequence Viewer
	XP_537646	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000023713.5
	ENSCAFP00000042966.2
	ENSCAFP00000072852.1
	ENSCAFP00030025166.1
	ENSCAFP00040023239.1
	ENSCAFP00040023429.1
	ENSCAFP00845011307
	ENSCAFP00845011307.1
	ENSCAFP00845011373.1
	ENSCAFP00845011528
	ENSCAFP00845011528.1

RefSeq Acc Id:	XP_537646 ⟸ XM_537646
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0SLK5 (UniProtKB/TrEMBL), A0A8I3MXG1 (UniProtKB/TrEMBL), A0A8C0NHM0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEVSPLQPVNENMQISKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVY DEDIGMNYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV EHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQ TWMDNMGRAGEMELRPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVF LNGNKLPVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVCLTMSEKGFQQISFVNSIATS KGGRHVDYIADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQ VKSFGSTCQLSEKFIKAATGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDANDAG GRNSNECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKNYDDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITP IVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKY SGPEDDAAISLAFSKKQIDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELI LFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTI INLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDQTLKFLYDD NQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFR GTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFE LRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVK AWKEAQQKVPDEEENEESDNENEAEKSDSVRDSGPTFNYLLDMPLWYLTKEKKDELCKLRNEKE QELETLKRKSPTDLWKEDLATFVEELEAVETKEKQEEQIGLPGKGGKGKGKKTQMAEVLPSPCG KRVIPRVTIEMKAEAEKKNKKKIKNENTEGSPQEESIEIEGLKQRLEKKQKREPGTKTKKQTTL PFKPIKKGKKRNPWSDSESDMSSNESNFDVPPREVEPRRAATKTKFTVDLDLDDSFSDFEERIQ DEDSVPSDVSPHKTKASPKRTAKELKPQKSAPPVMDLDADDAKDSVPLSPGSTADFLAETEIVN PLPKKKVDVKKIAPKSQSSTSTTGAKKRAAPKGTKKDPGLNSDVSQKPDPPKTKNHRKRKPSTS DDSDSNFEKMISKAATNKKSKGESEDFHLDLDSGVAPRAKSGRARKPIKYLEESDEDDLF hide sequence

Ensembl Acc Id:

ENSCAFP00000023713 ⟸ ENSCAFT00000025539

Ensembl Acc Id:

ENSCAFP00000042966 ⟸ ENSCAFT00000046104

RefSeq Acc Id:	XP_038341540 ⟸ XM_038485612
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038341539 ⟸ XM_038485611
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038467290 ⟸ XM_038611362
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038467289 ⟸ XM_038611361
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038532482 ⟸ XM_038676554
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0SLK5 (UniProtKB/TrEMBL), A0A8I3MXG1 (UniProtKB/TrEMBL), A0A8C0NHM0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038532481 ⟸ XM_038676553
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3N3P1 (UniProtKB/TrEMBL), A0A8P0NTK0 (UniProtKB/TrEMBL), A0A8C0NHM0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038459123 ⟸ XM_038603195
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3N3P1 (UniProtKB/TrEMBL), A0A8P0NTK0 (UniProtKB/TrEMBL), A0A8C0NHM0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038403306 ⟸ XM_038547378
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NHM0 (UniProtKB/TrEMBL), A0A8C0SLK5 (UniProtKB/TrEMBL), A0A8I3MXG1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845011373 ⟸ ENSCAFT00845014679

Ensembl Acc Id:

ENSCAFP00845011528 ⟸ ENSCAFT00845014873

Ensembl Acc Id:

ENSCAFP00845011307 ⟸ ENSCAFT00845014593

Protein Domains

Toprim

Promoters

RGD ID:

13684543

Promoter ID:

EPDNEW_C2610

Type:

multiple initiation site

Name:

TOP2A_1

Description:

DNA topoisomerase II alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	22,207,529 - 22,207,589	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016090	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030015461	UniProtKB/TrEMBL
	ENSCAFG00040014092	UniProtKB/TrEMBL
	ENSCAFG00845008263	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000025539.5	UniProtKB/TrEMBL
	ENSCAFT00000046104.4	UniProtKB/TrEMBL
	ENSCAFT00000096981.1	UniProtKB/TrEMBL
	ENSCAFT00030028867.1	UniProtKB/TrEMBL
	ENSCAFT00040026747.1	UniProtKB/TrEMBL
	ENSCAFT00040026960.1	UniProtKB/TrEMBL
	ENSCAFT00845014593	ENTREZGENE
	ENSCAFT00845014593.1	UniProtKB/TrEMBL
	ENSCAFT00845014679.1	UniProtKB/TrEMBL
	ENSCAFT00845014873	ENTREZGENE
	ENSCAFT00845014873.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.268.10	UniProtKB/TrEMBL
	3.30.1360.40	UniProtKB/TrEMBL
	3.30.1490.30	UniProtKB/TrEMBL
	3.30.230.10	UniProtKB/TrEMBL
	3.30.565.10	UniProtKB/TrEMBL
	3.40.50.670	UniProtKB/TrEMBL
	3.90.199.10	UniProtKB/TrEMBL
InterPro	DNA_Topoisomerase_II	UniProtKB/TrEMBL
	DTHCT	UniProtKB/TrEMBL
	HATPase_C	UniProtKB/TrEMBL
	HATPase_C_sf	UniProtKB/TrEMBL
	Ribosomal_S5_D2-typ_fold	UniProtKB/TrEMBL
	Ribosomal_S5_D2-typ_fold_subgr	UniProtKB/TrEMBL
	Topo_IIA	UniProtKB/TrEMBL
	Topo_IIA-like_dom_sf	UniProtKB/TrEMBL
	Topo_IIA_A/C	UniProtKB/TrEMBL
	Topo_IIA_A/C_ab	UniProtKB/TrEMBL
	Topo_IIA_A_a_sf	UniProtKB/TrEMBL
	Topo_IIA_B_C	UniProtKB/TrEMBL
	Topo_IIA_bsu_dom2	UniProtKB/TrEMBL
	TopoII_euk	UniProtKB/TrEMBL
	TopoIIA_CS	UniProtKB/TrEMBL
	TOPRIM_C	UniProtKB/TrEMBL
	TOPRIM_domain	UniProtKB/TrEMBL
	TOPRIM_TopoII	UniProtKB/TrEMBL
NCBI Gene	TOP2A	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 2-ALPHA	UniProtKB/TrEMBL
	DNA TOPOISOMERASE/GYRASE	UniProtKB/TrEMBL
Pfam	DNA_gyraseB	UniProtKB/TrEMBL
	DNA_topoisoIV	UniProtKB/TrEMBL
	DTHCT	UniProtKB/TrEMBL
	HATPase_c	UniProtKB/TrEMBL
	Toprim	UniProtKB/TrEMBL
	TOPRIM_C	UniProtKB/TrEMBL
PRINTS	TOPISMRASEII	UniProtKB/TrEMBL
	TPI2FAMILY	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_II	UniProtKB/TrEMBL
	TOPRIM	UniProtKB/TrEMBL
SMART	TOP2c	UniProtKB/TrEMBL
	TOP4c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54211	UniProtKB/TrEMBL
	SSF55874	UniProtKB/TrEMBL
	SSF56719	UniProtKB/TrEMBL
UniProt	A0A8C0NHM0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SLK5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SNU9_CANLF	UniProtKB/TrEMBL
	A0A8I3MXG1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MZ20_CANLF	UniProtKB/TrEMBL
	A0A8I3N3P1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NTK0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TRR3_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:49098	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-08	TOP2A	DNA topoisomerase II alpha		topoisomerase (DNA) II alpha	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB