PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) - Rat Genome Database

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Gene: PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) Canis lupus familiaris
Analyze
Symbol: PIK3CA
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RGD ID: 12218420
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); protein kinase activator activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adipose tissue development (ortholog); autosome genomic imprinting (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN intercalated disc (ortholog); lamellipodium (ortholog); phosphatidylinositol 3-kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,600,140 - 12,681,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,600,233 - 12,675,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,743,641 - 16,822,678 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,496,918 - 12,576,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,497,011 - 12,573,751 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,551,928 - 12,630,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,531,843 - 12,610,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,771,120 - 12,850,124 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
arteriovenous malformation  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
basal cell carcinoma  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast angiosarcoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Capillary Malformation-Arteriovenous Malformation 1  (ISO)
Cardiovascular Abnormalities  (ISO)
Cerebral Cavernous Malformation 4  (ISO)
CLAPO Syndrome  (ISO)
CLOVES syndrome  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
Cowden syndrome  (ISO)
Cowden syndrome 5  (ISO)
Currarino syndrome  (ISO)
cutaneous Paget's disease  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (ISO)
diaphragmatic eventration  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
estrogen-receptor positive breast cancer  (ISO)
Facial Asymmetry  (ISO)
familial multiple nevi flammei  (ISO)
gallbladder cancer  (ISO)
gallbladder carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glycogen storage disease II  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemifacial Myohyperplasia  (ISO)
Hemimegalencephaly  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
Hypertelorism  (ISO)
keratoacanthoma  (ISO)
Klippel-Trenaunay syndrome  (ISO)
liver cancer  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
medulloblastoma  (ISO)
Megalencephaly - Cutis Marmorata Telangiectatica Congenita  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome  (ISO)
Megalodactyly  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
non-Hodgkin lymphoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Penile Neoplasms  (ISO)
polycystic kidney disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
rosette-forming glioneuronal tumor  (ISO)
sarcoma  (ISO)
seborrheic keratosis  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Thyroid Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adipose tissue development  (ISO)
autosome genomic imprinting  (ISO)
cardiac muscle cell contraction  (ISO)
cell migration  (IBA)
cellular response to glucose stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to insulin stimulus  (ISO)
energy homeostasis  (ISO)
glucose metabolic process  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
liver development  (ISO)
negative regulation of actin filament depolymerization  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA,ISO)
phosphatidylinositol phosphate biosynthetic process  (IEA,ISO)
phosphatidylinositol-3-phosphate biosynthetic process  (IBA,IEA)
phosphatidylinositol-mediated signaling  (IBA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to membrane  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
regulation of actin filament organization  (ISO)
regulation of cellular respiration  (ISO)
regulation of gene expression  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of protein phosphorylation  (ISO)
relaxation of cardiac muscle  (ISO)
response to activity  (ISO)
response to butyrate  (ISO)
response to dexamethasone  (ISO)
response to L-leucine  (ISO)
response to muscle inactivity  (ISO)
response to muscle stretch  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
E-cadherin signaling pathway   (ISO)
endometrial cancer pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway   (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (ISO)
fibroblast growth factor signaling pathway  (ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway   (ISO)
Hedgehog signaling pathway  (ISO)
inositol metabolic pathway   (ISO)
insulin signaling pathway  (ISO)
insulin-like growth factor signaling pathway   (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway   (ISO)
interleukin-6 signaling pathway  (ISO)
N-cadherin signaling pathway   (ISO)
non-small cell lung carcinoma pathway   (ISO)
nuclear factor kappa B signaling pathway  (ISO)
phosphatidylinositol 3-kinase class I signaling pathway   (ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (ISO)
Reelin signaling pathway   (ISO)
Trail mediated signaling pathway  (ISO)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

References
Additional References at PubMed
PMID:22194879   PMID:22301074   PMID:30032202   PMID:31570656   PMID:32932196  


Genomics

Comparative Map Data
PIK3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,600,140 - 12,681,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,600,233 - 12,675,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,743,641 - 16,822,678 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,496,918 - 12,576,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,497,011 - 12,573,751 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,551,928 - 12,630,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,531,843 - 12,610,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,771,120 - 12,850,124 (+)NCBIUU_Cfam_GSD_1.0
PIK3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,148,126 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,148,114 - 179,240,093 (+)EnsemblGRCh38hg38GRCh38
GRCh373178,866,145 - 178,957,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,915,414 (+)NCBICHM1_1
T2T-CHM13v2.03181,951,917 - 182,043,930 (+)NCBIT2T-CHM13v2.0
Pik3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)EnsemblGRCm39 Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBIMGSCv36mm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
Pik3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,103,643 - 117,177,411 (+)NCBIGRCr8
mRatBN7.22115,175,275 - 115,249,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,174,984 - 115,249,032 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,832,703 - 121,862,791 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02119,945,342 - 119,975,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,646,275 - 114,676,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
Pik3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,356,353 - 8,427,024 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,355,415 - 8,427,024 (+)NCBIChiLan1.0ChiLan1.0
PIK3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,018,967 - 177,103,829 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,023,686 - 177,108,546 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,355,789 - 184,441,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensemblpanpan1.1panPan2
Pik3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,269,676 - 109,296,792 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,923,934 - 3,951,073 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,924,013 - 3,951,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,180,544 - 117,274,587 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,193,935 - 117,282,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213126,401,142 - 126,461,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,218,034 - 10,304,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,218,805 - 10,294,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606319,096,074 - 19,187,036 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473056,938,215 - 56,966,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473056,895,065 - 56,970,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PIK3CA
640 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022414352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038462744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_545208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000017863   ⟹   ENSCAFP00000016537
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3412,600,233 - 12,675,741 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000080543   ⟹   ENSCAFP00000048355
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3412,647,709 - 12,675,910 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845027831   ⟹   ENSCAFP00845021905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3412,497,011 - 12,573,751 (+)Ensembl
RefSeq Acc Id: XM_022414352   ⟹   XP_022270060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13412,647,785 - 12,681,905 (+)NCBI
Dog10K_Boxer_Tasha3416,791,439 - 16,822,678 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038445587   ⟹   XP_038301515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03412,496,918 - 12,572,791 (+)NCBI
RefSeq Acc Id: XM_038445588   ⟹   XP_038301516
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03412,497,762 - 12,572,791 (+)NCBI
RefSeq Acc Id: XM_038445589   ⟹   XP_038301517
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03412,544,891 - 12,576,076 (+)NCBI
RefSeq Acc Id: XM_038462744   ⟹   XP_038318672
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3416,744,485 - 16,819,393 (+)NCBI
RefSeq Acc Id: XM_038519766   ⟹   XP_038375694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13412,551,928 - 12,627,573 (+)NCBI
RefSeq Acc Id: XM_038519767   ⟹   XP_038375695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13412,552,755 - 12,627,573 (+)NCBI
RefSeq Acc Id: XM_038519768   ⟹   XP_038375696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13412,599,636 - 12,630,858 (+)NCBI
RefSeq Acc Id: XM_038583405   ⟹   XP_038439333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03412,771,120 - 12,846,839 (+)NCBI
RefSeq Acc Id: XM_038583406   ⟹   XP_038439334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03412,771,968 - 12,846,839 (+)NCBI
RefSeq Acc Id: XM_038583407   ⟹   XP_038439335
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03412,818,883 - 12,850,124 (+)NCBI
RefSeq Acc Id: XM_038647819   ⟹   XP_038503747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03412,531,843 - 12,607,551 (+)NCBI
RefSeq Acc Id: XM_038647820   ⟹   XP_038503748
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03412,532,673 - 12,607,551 (+)NCBI
RefSeq Acc Id: XM_038647821   ⟹   XP_038503749
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03412,579,567 - 12,610,836 (+)NCBI
RefSeq Acc Id: XM_545208   ⟹   XP_545208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13412,600,140 - 12,675,741 (+)NCBI
Dog10K_Boxer_Tasha3416,743,641 - 16,819,393 (+)NCBI
Sequence:
RefSeq Acc Id: XP_545208   ⟸   XM_545208
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022270060   ⟸   XM_022414352
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000016537   ⟸   ENSCAFT00000017863
Ensembl Acc Id: ENSCAFP00000048355   ⟸   ENSCAFT00000080543
RefSeq Acc Id: XP_038375694   ⟸   XM_038519766
RefSeq Acc Id: XP_038375695   ⟸   XM_038519767
RefSeq Acc Id: XP_038375696   ⟸   XM_038519768
RefSeq Acc Id: XP_038503747   ⟸   XM_038647819
RefSeq Acc Id: XP_038503748   ⟸   XM_038647820
RefSeq Acc Id: XP_038503749   ⟸   XM_038647821
RefSeq Acc Id: XP_038301515   ⟸   XM_038445587
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301516   ⟸   XM_038445588
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301517   ⟸   XM_038445589
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038318672   ⟸   XM_038462744
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439333   ⟸   XM_038583405
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439334   ⟸   XM_038583406
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439335   ⟸   XM_038583407
- UniProtKB: A0A5F4C2B1 (UniProtKB/TrEMBL),   A0A8C0LET4 (UniProtKB/TrEMBL),   A0A8C0T4B1 (UniProtKB/TrEMBL),   A0A8C0T7K1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845021905   ⟸   ENSCAFT00845027831
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Promoters
RGD ID:13688876
Promoter ID:EPDNEW_C6943
Type:initiation region
Name:PIK3CA_1
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunitalpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13412,599,979 - 12,600,039EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011212 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019156 UniProtKB/TrEMBL
  ENSCAFG00040019542 UniProtKB/TrEMBL
  ENSCAFG00845015587 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000080543.2 UniProtKB/TrEMBL
  ENSCAFT00030035277.1 UniProtKB/TrEMBL
  ENSCAFT00040036166.1 UniProtKB/TrEMBL
  ENSCAFT00040036237.1 UniProtKB/TrEMBL
  ENSCAFT00845027831 ENTREZGENE
  ENSCAFT00845027831.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K-type_C2_dom UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/TrEMBL
  PI3Kalpha_dom UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene PIK3CA ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM UniProtKB/TrEMBL
  PTHR10048 UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
PROSITE C2_PI3K UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A5F4C2B1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LET4 ENTREZGENE
  A0A8C0T4B1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T7K1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44555 ENTREZGENE