PLCG1 (phospholipase C gamma 1) - Rat Genome Database

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Gene: PLCG1 (phospholipase C gamma 1) Canis lupus familiaris
Analyze
Symbol: PLCG1
Name: phospholipase C gamma 1
RGD ID: 12206121
Description: ENCODES a protein that exhibits calcium-dependent phospholipase C activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); insulin receptor binding (ortholog); INVOLVED IN positive regulation of epithelial cell migration; calcium ion transport (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH acute myocardial infarction (ortholog); adult T-cell leukemia/lymphoma (ortholog); Alzheimer's disease (ortholog); FOUND IN clathrin-coated vesicle (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine; 1-stearoyl-2-arachidonoylphosphatidic acid; dihexadecanoyl phosphatidic acid
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12429,198,536 - 29,213,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2429,198,556 - 29,214,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2428,823,106 - 28,859,401 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02429,883,241 - 29,919,530 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2429,883,201 - 29,919,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12429,152,120 - 29,188,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02429,256,001 - 29,292,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02429,752,157 - 29,788,483 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Khurana S, etal., Exp Cell Res. 2008 Feb 1;314(3):530-42. doi: 10.1016/j.yexcr.2007.10.028. Epub 2007 Nov 12.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLCG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12429,198,536 - 29,213,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2429,198,556 - 29,214,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2428,823,106 - 28,859,401 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02429,883,241 - 29,919,530 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2429,883,201 - 29,919,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12429,152,120 - 29,188,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02429,256,001 - 29,292,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02429,752,157 - 29,788,483 (+)NCBIUU_Cfam_GSD_1.0
PLCG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382041,137,543 - 41,177,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2041,136,960 - 41,196,801 (+)EnsemblGRCh38hg38GRCh38
GRCh372039,766,183 - 39,806,266 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362039,199,575 - 39,237,771 (+)NCBINCBI36Build 36hg18NCBI36
Build 342039,199,574 - 39,237,771NCBI
Celera2036,476,730 - 36,514,924 (+)NCBICelera
Cytogenetic Map20q12NCBI
HuRef2036,504,215 - 36,542,409 (+)NCBIHuRef
CHM1_12039,670,573 - 39,708,755 (+)NCBICHM1_1
T2T-CHM13v2.02042,868,611 - 42,909,312 (+)NCBIT2T-CHM13v2.0
Plcg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392160,573,230 - 160,617,680 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2160,573,220 - 160,617,680 (+)EnsemblGRCm39 Ensembl
GRCm382160,731,310 - 160,775,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2160,731,300 - 160,775,760 (+)EnsemblGRCm38mm10GRCm38
MGSCv372160,557,046 - 160,601,496 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362160,422,751 - 160,467,201 (+)NCBIMGSCv36mm8
Celera2166,663,373 - 166,707,819 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.97NCBI
Plcg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83169,805,299 - 169,836,040 (+)NCBIGRCr8
mRatBN7.23149,385,587 - 149,416,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,385,587 - 149,416,330 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3153,198,699 - 153,229,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,698,084 - 161,728,848 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,437,731 - 159,468,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,727,642 - 156,758,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,727,642 - 156,758,307 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03162,957,126 - 162,987,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43151,522,949 - 151,553,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13151,428,984 - 151,460,034 (+)NCBI
Celera3148,059,477 - 148,090,220 (+)NCBICelera
RH 3.4 Map31368.6RGD
Cytogenetic Map3q42NCBI
Plcg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544515,787,496 - 15,823,859 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544515,787,496 - 15,823,859 (-)NCBIChiLan1.0ChiLan1.0
PLCG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,878,783 - 46,917,555 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12046,871,882 - 46,910,654 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02037,477,077 - 37,515,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12038,577,199 - 38,615,149 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2038,572,709 - 38,615,145 (+)Ensemblpanpan1.1panPan2
Plcg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640178,117,909 - 178,150,680 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936561598,382 - 631,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936561598,372 - 631,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1743,810,048 - 43,844,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11743,810,003 - 43,844,553 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21749,203,540 - 49,238,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1222,599,547 - 22,638,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605071,416,788 - 71,455,730 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249191,766,149 - 1,803,097 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249191,766,533 - 1,800,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLCG1
117 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005635060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022408860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038572317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038572318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000014441   ⟹   ENSCAFP00000013354
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2429,198,556 - 29,212,611 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000070025   ⟹   ENSCAFP00000046841
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2429,198,556 - 29,214,714 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845053205   ⟹   ENSCAFP00845041776
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2429,883,201 - 29,919,502 (+)Ensembl
RefSeq Acc Id: XM_038433833   ⟹   XP_038289761
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02429,883,241 - 29,919,530 (+)NCBI
RefSeq Acc Id: XM_038433834   ⟹   XP_038289762
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02429,883,262 - 29,919,530 (+)NCBI
RefSeq Acc Id: XM_038457654   ⟹   XP_038313582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2428,823,106 - 28,859,401 (+)NCBI
RefSeq Acc Id: XM_038457655   ⟹   XP_038313583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2428,823,127 - 28,859,401 (+)NCBI
RefSeq Acc Id: XM_038508979   ⟹   XP_038364907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12429,152,120 - 29,188,420 (+)NCBI
RefSeq Acc Id: XM_038508980   ⟹   XP_038364908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12429,152,141 - 29,188,420 (+)NCBI
RefSeq Acc Id: XM_038572317   ⟹   XP_038428245
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02429,752,157 - 29,788,483 (+)NCBI
RefSeq Acc Id: XM_038572318   ⟹   XP_038428246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02429,752,178 - 29,788,483 (+)NCBI
RefSeq Acc Id: XM_038636570   ⟹   XP_038492498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02429,256,001 - 29,292,271 (+)NCBI
RefSeq Acc Id: XM_038636571   ⟹   XP_038492499
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02429,256,022 - 29,292,271 (+)NCBI
Ensembl Acc Id: ENSCAFP00000046841   ⟸   ENSCAFT00000070025
Ensembl Acc Id: ENSCAFP00000013354   ⟸   ENSCAFT00000014441
RefSeq Acc Id: XP_038364907   ⟸   XM_038508979
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038364908   ⟸   XM_038508980
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038492498   ⟸   XM_038636570
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038492499   ⟸   XM_038636571
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038289761   ⟸   XM_038433833
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MEC3 (UniProtKB/TrEMBL),   A0A8C0Z363 (UniProtKB/TrEMBL),   A0A8C0KG77 (UniProtKB/TrEMBL),   A0A8I3SCI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038289762   ⟸   XM_038433834
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MEC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313582   ⟸   XM_038457654
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MEC3 (UniProtKB/TrEMBL),   A0A8C0Z363 (UniProtKB/TrEMBL),   A0A8C0KG77 (UniProtKB/TrEMBL),   A0A8I3SCI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313583   ⟸   XM_038457655
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MEC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038428245   ⟸   XM_038572317
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KG77 (UniProtKB/TrEMBL),   A0A8C0MEC3 (UniProtKB/TrEMBL),   A0A8C0Z363 (UniProtKB/TrEMBL),   A0A8I3SCI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038428246   ⟸   XM_038572318
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MEC3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845041776   ⟸   ENSCAFT00845053205
Protein Domains
C2   EF-hand   PH   PI-PLC Y-box   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009082 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006182 UniProtKB/TrEMBL
  ENSCAFG00040020236 UniProtKB/TrEMBL
  ENSCAFG00845030031 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000070025.2 UniProtKB/TrEMBL
  ENSCAFT00030011843.1 UniProtKB/TrEMBL
  ENSCAFT00030011977.1 UniProtKB/TrEMBL
  ENSCAFT00040038050.1 UniProtKB/TrEMBL
  ENSCAFT00040038192.1 UniProtKB/TrEMBL
  ENSCAFT00845053205 ENTREZGENE
  ENSCAFT00845053205.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-gamma UniProtKB/TrEMBL
  PLC-gamma_C-SH2 UniProtKB/TrEMBL
  PLC-gamma_N-SH2 UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLCgamma1_SH3 UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene PLCG1 ENTREZGENE
PANTHER PTHR10336 UniProtKB/TrEMBL
  PTHR10336:SF173 UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PIRSF PLC-gamma UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8C0KG77 ENTREZGENE
  A0A8C0MEC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z363 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3SCI7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44651 ENTREZGENE