ALPI (alkaline phosphatase, intestinal) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: ALPI (alkaline phosphatase, intestinal) Canis lupus familiaris
Analyze
Symbol: ALPI
Name: alkaline phosphatase, intestinal
RGD ID: 12192371
Description: ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); magnesium ion binding (ortholog); protease binding (ortholog); INVOLVED IN cellular response to BMP stimulus (ortholog); dephosphorylation (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Dysbiosis (ortholog); inflammatory bowel disease (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 4-nitrophenyl phosphate; acetophenone; estrone
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkaline phosphatase, placental; ALPP; intestinal-type alkaline phosphatase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,107,418 - 44,110,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ALPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,107,418 - 44,110,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBIUU_Cfam_GSD_1.0
ALPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,456,153 - 232,460,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,456,125 - 232,460,753 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,320,863 - 233,325,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,029,077 - 233,032,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 342233,146,369 - 233,150,245NCBI
Celera2227,085,143 - 227,089,052 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2225,171,620 - 225,175,529 (+)NCBIHuRef
CHM1_12233,326,952 - 233,330,861 (+)NCBICHM1_1
T2T-CHM13v2.02232,942,959 - 232,947,559 (+)NCBIT2T-CHM13v2.0
Alpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,025,724 - 87,029,328 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,025,724 - 87,029,328 (-)EnsemblGRCm39 Ensembl
GRCm38187,098,002 - 87,101,606 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,098,002 - 87,101,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,994,579 - 88,998,181 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,929,175 - 88,932,777 (-)NCBIMGSCv36mm8
Celera190,070,193 - 90,073,795 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map144.05NCBI
Alpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,221,314 - 95,224,780 (-)NCBIGRCr8
mRatBN7.2987,773,411 - 87,776,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,773,411 - 87,776,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx996,197,663 - 96,201,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,333,414 - 101,336,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,701,666 - 99,705,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,197,616 - 94,201,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,197,618 - 94,201,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,922,817 - 93,926,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,892,887 - 85,896,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1986,076,305 - 86,079,772 (-)NCBI
Celera985,187,115 - 85,190,581 (-)NCBICelera
Cytogenetic Map9q35NCBI
ALPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213135,061,545 - 135,066,147 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B135,076,510 - 135,081,112 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B119,687,673 - 119,692,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B238,606,722 - 238,611,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B238,606,722 - 238,611,350 (+)Ensemblpanpan1.1panPan2
LOC101973915
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303186,319,789 - 186,323,568 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365254,616,212 - 4,619,932 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103218081
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110118,475,701 - 118,480,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10118,476,215 - 118,479,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604081,022,806 - 81,072,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248435,237,041 - 5,239,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALPI
59 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 21 15 5 6 5 6 32 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00845044518   ⟹   ENSCAFP00845034882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845044640   ⟹   ENSCAFP00845034976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
RefSeq Acc Id: XM_038434590   ⟹   XP_038290518
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBI
RefSeq Acc Id: XM_038509670   ⟹   XP_038365598
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBI
RefSeq Acc Id: XM_038573026   ⟹   XP_038428954
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBI
RefSeq Acc Id: XM_038637283   ⟹   XP_038493211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBI
RefSeq Acc Id: XM_534605   ⟹   XP_534605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12544,107,418 - 44,110,947 (+)NCBI
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBI
Sequence:
RefSeq Acc Id: XP_534605   ⟸   XM_534605
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PK10 (UniProtKB/TrEMBL),   A0A8P0ND52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038365598   ⟸   XM_038509670
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038493211   ⟸   XM_038637283
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038290518   ⟸   XM_038434590
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PK10 (UniProtKB/TrEMBL),   A0A8P0ND52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038428954   ⟸   XM_038573026
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PK10 (UniProtKB/TrEMBL),   A0A8P0ND52 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845034882   ⟸   ENSCAFT00845044518
Ensembl Acc Id: ENSCAFP00845034976   ⟸   ENSCAFT00845044640


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011195 UniProtKB/TrEMBL
  ENSCAFG00845025234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017792.5 UniProtKB/TrEMBL
  ENSCAFT00000079486.2 UniProtKB/TrEMBL
  ENSCAFT00845044518 ENTREZGENE
  ENSCAFT00845044518.1 UniProtKB/TrEMBL
  ENSCAFT00845044640.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
NCBI Gene ALPI ENTREZGENE
PANTHER INTESTINAL-TYPE ALKALINE PHOSPHATASE UniProtKB/TrEMBL
  PTHR11596 UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/TrEMBL
PRINTS ALKPHPHTASE UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/TrEMBL
SMART alkPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
UniProt A0A8I3PK10 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PPF2_CANLF UniProtKB/TrEMBL
  A0A8P0ND52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TFC0_CANLF UniProtKB/TrEMBL