NELFA (negative elongation factor complex member A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: NELFA (negative elongation factor complex member A) Canis lupus familiaris
Analyze
Symbol: NELFA
Name: negative elongation factor complex member A
RGD ID: 12180648
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription elongation by RNA polymerase II (ortholog); positive regulation of protein modification process (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH cherubism (ortholog); FOUND IN cytosol (inferred); NELF complex (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: negative elongation factor A; WHSC2; Wolf-Hirschhorn syndrome candidate 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,147,948 - 62,164,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,147,948 - 62,164,112 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,665,674 - 64,682,273 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,623,281 - 62,639,884 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,623,336 - 62,639,877 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,115,860 - 62,133,779 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,319,512 - 62,337,145 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,679,577 - 62,696,178 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
cherubism  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
NELF complex  (IBA,IEA)
nuclear body  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NELFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,147,948 - 62,164,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,147,948 - 62,164,112 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,665,674 - 64,682,273 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,623,281 - 62,639,884 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,623,336 - 62,639,877 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,115,860 - 62,133,779 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,319,512 - 62,337,145 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,679,577 - 62,696,178 (+)NCBIUU_Cfam_GSD_1.0
NELFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,982,723 - 2,008,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,982,717 - 2,041,903 (-)EnsemblGRCh38hg38GRCh38
GRCh3741,984,450 - 2,010,701 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,954,248 - 1,980,547 (-)NCBINCBI36Build 36hg18NCBI36
Build 3441,951,683 - 1,977,980NCBI
Celera41,896,671 - 1,923,194 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,925,800 - 1,952,332 (-)NCBIHuRef
CHM1_141,983,104 - 2,009,627 (-)NCBICHM1_1
T2T-CHM13v2.041,981,232 - 2,007,492 (-)NCBIT2T-CHM13v2.0
Nelfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,055,263 - 34,093,615 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,055,260 - 34,093,757 (-)EnsemblGRCm39 Ensembl
GRCm38533,897,916 - 33,936,301 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,897,916 - 33,936,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37534,240,828 - 34,278,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,215,036 - 34,253,115 (-)NCBIMGSCv36mm8
Celera531,375,430 - 31,405,361 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Nelfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,033,470 - 81,057,546 (+)NCBIGRCr8
mRatBN7.21476,808,920 - 76,832,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,808,870 - 76,832,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,260,792 - 81,284,853 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,501,435 - 82,525,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,946,688 - 78,970,749 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,093,837 - 82,117,913 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,093,837 - 82,117,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,778,077 - 82,802,153 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,502,840 - 82,526,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,505,230 - 82,529,304 (+)NCBI
Celera1475,732,469 - 75,756,545 (+)NCBICelera
Cytogenetic Map14q21NCBI
Nelfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,162,993 - 1,173,278 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,162,993 - 1,173,278 (-)NCBIChiLan1.0ChiLan1.0
NELFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,310,013 - 2,374,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,247,052 - 2,311,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,119,699 - 2,147,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,027,939 - 2,054,669 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,027,939 - 2,054,669 (-)Ensemblpanpan1.1panPan2
Nelfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,740,863 - 67,758,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,442,380 - 21,464,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,442,493 - 21,459,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,018,453 - 1,039,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,018,443 - 1,039,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28515,274 - 626,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,759,742 - 46,786,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,760,707 - 46,787,090 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,131,850 - 3,158,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nelfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,498,431 - 25,508,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,498,336 - 25,508,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NELFA
173 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023690   ⟹   ENSCAFP00000021993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl362,147,948 - 62,164,112 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845022907   ⟹   ENSCAFP00845017957
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl362,623,336 - 62,639,877 (+)Ensembl
RefSeq Acc Id: XM_038472289   ⟹   XP_038328217
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1362,115,860 - 62,133,779 (+)NCBI
RefSeq Acc Id: XM_038472290   ⟹   XP_038328218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1362,115,967 - 62,133,428 (+)NCBI
RefSeq Acc Id: XM_038478823   ⟹   XP_038334751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha364,665,674 - 64,682,273 (+)NCBI
RefSeq Acc Id: XM_038533265   ⟹   XP_038389193
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0362,679,577 - 62,696,178 (+)NCBI
RefSeq Acc Id: XM_038533266   ⟹   XP_038389194
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0362,679,684 - 62,695,827 (+)NCBI
RefSeq Acc Id: XM_038597591   ⟹   XP_038453519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0362,319,512 - 62,337,145 (+)NCBI
RefSeq Acc Id: XM_038597592   ⟹   XP_038453520
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0362,319,619 - 62,336,794 (+)NCBI
RefSeq Acc Id: XM_038661775   ⟹   XP_038517703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0362,623,281 - 62,639,884 (+)NCBI
RefSeq Acc Id: XM_038661776   ⟹   XP_038517704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0362,623,388 - 62,639,533 (+)NCBI
RefSeq Acc Id: XM_545924   ⟹   XP_545924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1362,147,948 - 62,164,039 (+)NCBI
Dog10K_Boxer_Tasha364,665,781 - 64,681,922 (+)NCBI
Sequence:
RefSeq Acc Id: XP_545924   ⟸   XM_545924
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHD6 (UniProtKB/TrEMBL),   A0A8I3NYG9 (UniProtKB/TrEMBL),   A0A8P0SJG0 (UniProtKB/TrEMBL),   A0A8C0PFY8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021993   ⟸   ENSCAFT00000023690
RefSeq Acc Id: XP_038328217   ⟸   XM_038472289
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038328218   ⟸   XM_038472290
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038453519   ⟸   XM_038597591
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038453520   ⟸   XM_038597592
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038517703   ⟸   XM_038661775
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PFY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038517704   ⟸   XM_038661776
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHD6 (UniProtKB/TrEMBL),   A0A8I3NYG9 (UniProtKB/TrEMBL),   A0A8P0SJG0 (UniProtKB/TrEMBL),   A0A8C0PFY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038334751   ⟸   XM_038478823
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PFY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389193   ⟸   XM_038533265
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PFY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389194   ⟸   XM_038533266
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHD6 (UniProtKB/TrEMBL),   A0A8C0PFY8 (UniProtKB/TrEMBL),   A0A8I3NYG9 (UniProtKB/TrEMBL),   A0A8P0SJG0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845017957   ⟸   ENSCAFT00845022907
Protein Domains
HDAg

Promoters
RGD ID:13682805
Promoter ID:EPDNEW_C872
Type:multiple initiation site
Name:NELFA_1
Description:negative elongation factor complex member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1362,147,932 - 62,147,992EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014927 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021547 UniProtKB/TrEMBL
  ENSCAFG00845012841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023690.5 UniProtKB/TrEMBL
  ENSCAFT00030039565.1 UniProtKB/TrEMBL
  ENSCAFT00845022907 ENTREZGENE
  ENSCAFT00845022907.1 UniProtKB/TrEMBL
InterPro HDAG_dom UniProtKB/TrEMBL
  NELF-A_domain UniProtKB/TrEMBL
NCBI Gene NELFA ENTREZGENE
PANTHER NEGATIVE ELONGATION FACTOR A UniProtKB/TrEMBL
  NEGATIVE ELONGATION FACTOR A NELF-A UniProtKB/TrEMBL
PROSITE HDAG UniProtKB/TrEMBL
UniProt A0A8C0KHD6 ENTREZGENE
  A0A8C0PFY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NYG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SJG0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43736 ENTREZGENE