NOP2 (NOP2 nucleolar protein) - Rat Genome Database

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Gene: NOP2 (NOP2 nucleolar protein) Canis lupus familiaris
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Symbol: NOP2
Name: NOP2 nucleolar protein
RGD ID: 12180047
Description: ENCODES a protein that exhibits methyltransferase activity (inferred); RNA binding (inferred); RNA methyltransferase activity (inferred); INVOLVED IN blastocyst formation (ortholog); ASSOCIATED WITH Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); lymphoproliferative syndrome 2 (ortholog); peroxisome biogenesis disorder 2B (ortholog); FOUND IN nucleolus (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NOL1; NOP2 nucleolar protein homolog; nucleolar protein 1, 120kDa; probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,441,259 - 38,453,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,441,690 - 38,453,824 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,162,718 - 8,175,429 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,795,791 - 38,808,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,795,860 - 38,808,510 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,667,821 - 38,680,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,709,346 - 38,722,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,641,408 - 7,654,127 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (IBA,IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NOP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,441,259 - 38,453,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,441,690 - 38,453,824 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,162,718 - 8,175,429 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,795,791 - 38,808,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,795,860 - 38,808,510 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,667,821 - 38,680,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,709,346 - 38,722,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,641,408 - 7,654,127 (-)NCBIUU_Cfam_GSD_1.0
NOP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,556,871 - 6,568,291 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,556,863 - 6,568,691 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,666,037 - 6,677,457 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,536,298 - 6,547,741 (-)NCBINCBI36Build 36hg18NCBI36
Build 34126,536,289 - 6,547,345NCBI
Celera128,282,899 - 8,294,342 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,520,171 - 6,531,576 (-)NCBIHuRef
CHM1_1126,665,044 - 6,676,501 (-)NCBICHM1_1
T2T-CHM13v2.0126,567,230 - 6,578,651 (-)NCBIT2T-CHM13v2.0
Nop2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,108,829 - 125,121,716 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,108,872 - 125,121,716 (+)EnsemblGRCm39 Ensembl
GRCm386125,131,883 - 125,144,753 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,131,909 - 125,144,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,081,901 - 125,094,771 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,097,558 - 125,110,372 (+)NCBIMGSCv36mm8
Celera6126,801,863 - 126,814,607 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.32NCBI
Nop2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,618,894 - 159,630,697 (+)NCBIGRCr8
mRatBN7.24157,932,731 - 157,944,462 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,932,716 - 157,944,459 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,161,797 - 164,173,528 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,944,712 - 159,956,443 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,580,682 - 158,592,424 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,646,759 - 157,658,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,647,082 - 157,658,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,663,955 - 224,675,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,252,117 - 161,264,321 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,497,375 - 161,509,257 (+)NCBI
Celera4146,669,575 - 146,681,484 (+)NCBICelera
Cytogenetic Map4q42NCBI
Nop2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,180,573 - 4,190,490 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,180,463 - 4,190,827 (-)NCBIChiLan1.0ChiLan1.0
NOP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,118,734 - 12,130,299 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,115,491 - 12,127,002 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,687,763 - 6,699,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,606,036 - 6,617,260 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,606,036 - 6,617,260 (-)Ensemblpanpan1.1panPan2
Nop2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,547,510 - 102,560,568 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367091,215,100 - 1,228,117 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,106,098 - 64,115,579 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,106,013 - 64,115,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,463,609 - 66,473,180 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,590,518 - 6,601,981 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,590,642 - 6,601,552 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,622,901 - 1,634,416 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nop2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248603,273,944 - 3,284,150 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NOP2
110 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023862   ⟹   ENSCAFP00000022151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,441,690 - 38,453,824 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845050875   ⟹   ENSCAFP00845039884
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2738,795,860 - 38,808,510 (+)Ensembl
RefSeq Acc Id: XM_005637232   ⟹   XP_005637289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12738,441,259 - 38,453,946 (+)NCBI
Dog10K_Boxer_Tasha278,162,718 - 8,175,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038439191   ⟹   XP_038295119
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02738,795,791 - 38,808,510 (+)NCBI
RefSeq Acc Id: XM_038513837   ⟹   XP_038369765
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12738,667,821 - 38,680,527 (+)NCBI
RefSeq Acc Id: XM_038576582   ⟹   XP_038432510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0277,641,408 - 7,654,127 (-)NCBI
RefSeq Acc Id: XM_038641680   ⟹   XP_038497608
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02738,709,346 - 38,722,054 (+)NCBI
RefSeq Acc Id: XP_005637289   ⟸   XM_005637232
- UniProtKB: A0A8C0T457 (UniProtKB/TrEMBL),   A0A8P0NGK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000022151   ⟸   ENSCAFT00000023862
RefSeq Acc Id: XP_038369765   ⟸   XM_038513837
RefSeq Acc Id: XP_038497608   ⟸   XM_038641680
RefSeq Acc Id: XP_038295119   ⟸   XM_038439191
- UniProtKB: A0A8C0JMZ6 (UniProtKB/TrEMBL),   A0A8I3Q5B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432510   ⟸   XM_038576582
- UniProtKB: A0A8C0T457 (UniProtKB/TrEMBL),   A0A8P0NGK1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845039884   ⟸   ENSCAFT00845050875

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015034 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023162 UniProtKB/TrEMBL
  ENSCAFG00040019177 UniProtKB/TrEMBL
  ENSCAFG00845028743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023862.5 UniProtKB/TrEMBL
  ENSCAFT00030043000.1 UniProtKB/TrEMBL
  ENSCAFT00040036050.1 UniProtKB/TrEMBL
  ENSCAFT00845050875 ENTREZGENE
  ENSCAFT00845050875.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  Sun protein, domain 3 UniProtKB/TrEMBL
InterPro Fmu/NOL1/Nop2p_CS UniProtKB/TrEMBL
  MeTrfase_RsmB-F_NOP2_cat UniProtKB/TrEMBL
  MeTrfase_RsmB/NOP2 UniProtKB/TrEMBL
  Nop2p UniProtKB/TrEMBL
  RCMT UniProtKB/TrEMBL
  RCMT_NOP2 UniProtKB/TrEMBL
  RsmB-like_ferredoxin UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report cfa:611645 UniProtKB/TrEMBL
NCBI Gene NOP2 ENTREZGENE
PANTHER 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED UniProtKB/TrEMBL
  PTHR22807 UniProtKB/TrEMBL
Pfam Methyltr_RsmB-F UniProtKB/TrEMBL
  RsmF-B_ferredox UniProtKB/TrEMBL
PRINTS RCMTFAMILY UniProtKB/TrEMBL
  RCMTNOP2 UniProtKB/TrEMBL
PROSITE NOL1_NOP2_SUN UniProtKB/TrEMBL
  SAM_MT_RSMB_NOP UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8C0JMZ6 ENTREZGENE
  A0A8C0T457 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q5B1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NGK1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43889 ENTREZGENE