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Gene: USH1C (USH1 protein network component harmonin) Canis lupus familiaris

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Symbol:

USH1C

Name:

USH1 protein network component harmonin

RGD ID:

12153450

Description:

ENCODES a protein that exhibits spectrin binding (inferred); INVOLVED IN actin filament bundle assembly (ortholog); inner ear auditory receptor cell differentiation (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ortholog); Autosomal Recessive Nonsyndromic Deafness 18 (ortholog); autosomal recessive nonsyndromic deafness 18A (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

harmonin; Usher syndrome 1C (autosomal recessive, severe)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	40,055,786 - 40,100,685 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	40,055,730 - 40,101,430 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	39,555,651 - 39,600,543 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	41,161,015 - 41,205,900 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	41,160,539 - 41,205,845 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	40,173,714 - 40,218,550 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	40,380,893 - 40,425,786 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	40,719,734 - 40,764,634 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness (ISO)

Autosomal Recessive Nonsyndromic Deafness 18 (ISO)

autosomal recessive nonsyndromic deafness 18A (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

intellectual disability (ISO)

Meniere's disease (ISO)

optic atrophy (ISO)

progressive myoclonus epilepsy 7 (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

sensorineural hearing loss (ISO)

Usher syndrome (ISO)

Usher syndrome type 1 (ISO)

Usher Syndrome Type 1B (ISO)

Usher syndrome type 1C (ISO)

Usher syndrome type 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (ISO)

auditory receptor cell morphogenesis (IBA)

brush border assembly (IEA)

equilibrioception (IEA)

G2/M transition of mitotic cell cycle (IEA)

inner ear auditory receptor cell differentiation (ISO)

inner ear morphogenesis (ISO)

inner ear receptor cell stereocilium organization (IBA,ISO)

neuromuscular process controlling balance (ISO)

parallel actin filament bundle assembly (ISO)

photoreceptor cell maintenance (IEA)

protein localization to microvillus (IEA)

protein-containing complex assembly (IEA)

regulation of microvillus length (ISO)

retinal cone cell development (IBA)

sensory perception of light stimulus (IEA)

sensory perception of sound (IBA,IEA,ISO)

Cellular Component

apical part of cell (IEA)

brush border (IEA)

cell projection (IEA)

cilium (IBA)

cytoplasm (IEA)

cytosol (IEA)

microvillus (IEA)

photoreceptor inner segment (IBA,ISO)

photoreceptor outer segment (ISO)

plasma membrane (IBA,ISO)

stereocilia ankle link complex (IBA)

stereocilium (ISO)

stereocilium tip (IBA)

synapse (ISO)

upper tip-link density (ISO)

Molecular Function

protein binding (ISO)

spectrin binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

retinitis pigmentosa pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

USH1C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	40,055,786 - 40,100,685 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	40,055,730 - 40,101,430 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	39,555,651 - 39,600,543 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	41,161,015 - 41,205,900 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	41,160,539 - 41,205,845 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	40,173,714 - 40,218,550 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	40,380,893 - 40,425,786 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	40,719,734 - 40,764,634 (-)	NCBI		UU_Cfam_GSD_1.0

USH1C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	17,493,900 - 17,544,416 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	17,493,895 - 17,544,416 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	17,515,447 - 17,565,963 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	17,472,018 - 17,522,539 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	17,645,289 - 17,695,946 (-)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	17,199,243 - 17,249,828 (-)	NCBI		HuRef
CHM1_1	11	17,515,265 - 17,565,784 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	17,591,495 - 17,642,149 (-)	NCBI		T2T-CHM13v2.0

Ush1c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	45,844,774 - 45,887,984 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	45,844,774 - 45,887,927 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	46,195,350 - 46,238,490 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	46,195,350 - 46,238,503 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	53,450,721 - 53,493,860 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	46,063,399 - 46,106,532 (-)	NCBI		MGSCv36	mm8
Celera	7	41,668,925 - 41,712,073 (-)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	29.66	NCBI

Ush1c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	105,831,719 - 105,880,082 (-)	NCBI		GRCr8
mRatBN7.2	1	96,695,303 - 96,743,671 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	96,695,307 - 96,743,671 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	102,081,448 - 102,129,809 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	110,553,421 - 110,601,783 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	103,843,796 - 103,892,162 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	102,207,096 - 102,256,779 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	102,207,096 - 102,255,459 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	103,291,318 - 103,340,928 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	96,720,185 - 96,768,550 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	96,798,295 - 96,846,661 (-)	NCBI
Celera	1	90,943,948 - 90,992,307 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Ush1c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	32,298,759 - 32,351,505 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	32,303,045 - 32,351,401 (-)	NCBI	ChiLan1.0	ChiLan1.0

USH1C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	19,827,448 - 19,877,874 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	19,787,920 - 19,838,443 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	17,548,501 - 17,598,923 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	17,233,854 - 17,284,256 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	17,233,854 - 17,284,256 (-)	Ensembl	panpan1.1		panPan2

Ush1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	45,513,303 - 45,560,765 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	1,552,289 - 1,594,801 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	1,552,175 - 1,594,740 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USH1C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	41,593,802 - 41,647,247 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	41,593,793 - 41,646,777 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	44,613,841 - 44,706,204 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USH1C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	47,428,181 - 47,477,578 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	47,437,596 - 47,477,834 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	144,848,688 - 144,898,245 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ush1c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	9,105,990 - 9,153,663 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	9,097,466 - 9,153,602 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in USH1C
726 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	21	21	15	6	6	6	4	31	20	12	14	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014122770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038430637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038505963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038569185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038633377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000014322 ⟹ ENSCAFP00000013245

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	21	40,055,731 - 40,101,430 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000014325 ⟹ ENSCAFP00000013248

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	21	40,055,730 - 40,101,430 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000077248 ⟹ ENSCAFP00000053334

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	21	40,055,731 - 40,101,430 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845025797 ⟹ ENSCAFP00845020326

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	21	41,160,539 - 41,205,838 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845025838 ⟹ ENSCAFP00845020359

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	21	41,160,539 - 41,205,838 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845025859 ⟹ ENSCAFP00845020376

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	21	41,160,961 - 41,205,845 (-)	Ensembl

RefSeq Acc Id:

XM_014122770 ⟹ XP_013978245

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	21	40,055,786 - 40,100,685 (-)	NCBI
Dog10K_Boxer_Tasha	21	39,555,651 - 39,600,543 (-)	NCBI

Sequence:

show sequence

GGCCCCGCCCCCCCGCTCCCGGGCCCGCGGATCTCCGCTGCGGCTCCTGCCGGCTTGGGGCCTC
CGGGCACCCGAAGGAGCGAGTTGTGCGGGCGACGCGGCTCCGCCTGGCCCAGCCATGGACCGGA
AGGTGGCTCGAGAATTCCGGCACAAGGTGGATTTTCTGATTGAAAATGATGCAGAGAAGGACTA
TCTGTATGACGTGCTGCGGATGTATCACCAAACCATGGACGTGGCCGTGTTCGTGGGAGACCTG
AAGCTGGTCATCAATGAGCCTAGCCGCCTGCCACTATTTGACGCCATCAGACCCCTGATCCCGC
TGAAGCACCAGGTGGAGTACGACCAACTGACCCCCCGGCGCTCCAGGAAGCTGAAGGAGGTGCG
TCTGGACCGTCTGCACCCCGAAGGCCTGGGCCTCAGTGTTCGTGGGGGCCTCGAGTTTGGCTGC
GGGCTCTTCATCTCCCACCTCATCAAAGGCGGTCAGGCTGACAGCGTTGGGCTCCAGGTAGGGG
ATGAGATCGTGCGCATCAACGGATATTCCATCTCCTCCTGCACCCACGAGGAGGTCATCAACCT
TATCAGGACCAAGAAGACTGTGTCCATCAAAGTGAGACACATTGGCCTGATTCCTGTGAAGAGC
TCTCCTGACGAACCCCTCAAATGGCAGTACGTGGATCAGTTTGTGTCAGAATCCGAGGGTGGGC
GGAGTACCCTGAGCTTCCCCGGCAGTCGGGAAAACAAGGAGAAGAAGGTCTTCATCAGCCTTGT
GGGATCCCGGGGCCTTGGCTGCAGCATTTCCAGTGGGCCCGTCCAGAAACCCGGCATCTTTATC
AGCCACGTGAAGCCTGGCTCCCTGTCTGCCGAGGTGGGGTTAGAGGCAGGGGACCAGATTGTCG
AAGTCAATGGCATCGACTTCTCCAACCTGGACCACAAGGAGGCCGTGAACGTGCTGAAGAGTAG
CCGCAGCCTGACCATCTCCATTGTAGCTGGAGCTGGCCGGGAGCTGTTCCTGACAGACCGGGAG
CGGCTGGAGGAGGCACGGCAGCGTGAGCTGCAGCGGCAGGAGCTTCTCATGCAGAAGCGGCTGG
CTATGGAGTCCAACAAGATCCTCCAGGAGCAGCAGGAGATGGAGCGACAAAGGAAAAAGGAAAT
TGCCCAGAAGGCAGCAGAGGAGAATGAAAGATACCGGAAGGAGATGGAGCAGATTGTGGAAGAG
GAGGAGAAGTTTAAGAAGCAGTGGGAAGAAGACTGGGGCTCAAAGGAACAGCTGCTCTCACCTA
AAACCATCACCGCAGAGGTGCACCCAATACCCCTTCGCAAGCCTAAGTCCTTTGGGTGGTTTTA
TCGTTATGATGGCAAGTTCCCGACCATCCGGAAGAAAGGAAAGGATAAGAAGAAAACCAAGTAT
GACAGCCTACAGGAGTTGAGAAAGAATAAGAAGGAACTAGAGTTTGAGCAAAAGCTTTACAAAG
AGAAAGAGGAAATGCTGGAAAAGGAGAAACAACTGAAGATAAACCGGCTGGCCCAGGAGGTGTC
TGAGACAGAGCGAGAAGACCTTGAGGAATCGGAAAAGATTCAGTATTGGGTGGAAAGGCTATGT
CAGACACGCCTTGAGCAGATTTCCTCTGCTGATAATGAGATTTCAGAGATGACTACGGGGCCCC
CGCCTCCCCCACCTTCGGTGTCTCCCCTGGCCCCACCCCTGAGACGCTTCGCAGGCGGGCTGCA
CCTCCACACCACTGACCTGGATGACATCCCCTTGGACATGTTCTACTATCCTCCCAAGACTCCC
TCCGCCTTACCTGTGATGCCCCACCCTCCACCCTCCAACCCATCCCCCAAGATCCCTGCACCCC
CTGTCCTTTCATCCTCAGGCCGTGTGAGTGCCTCATCTTCACCCTGGGTGCAACGCACTCCACC
CCCCATTCCCATCCCTCCCCCACCATCTATTCCCACCCAAGACCTGACTCCTACCCGCCCGCTA
CCCTCGGCACTGGAAGAGGCACTGGGCAACCACCCCTTCCGTGCTGGGGACACAGGAAATCCAA
CAGAGGACTGGGAGGCAAAGAACCACAGTGGCAAGCCCACTAACTCCCCTGTTCCTGAACGGAG
CTTCCCACCCACCCCCAAGACATTTTGCCCAAGCCCTCAGCCTCCACGAGGCCCTGGCGTGTCT
ACTATCTCCAAACCGGTCATGGTCCACCAGGAGTCCAACTTCATCTACAGGCCAGCTGTGAAAT
CGGAGGTCCTGCCACAGGAGATGTTGAAGAGGATGGTGGTTTATCAGACAGCGTTCAGACAAGA
TTTCCGGAAATATGAGGAAGGCTTTGACCCCTACTCGATGTTCACCCCGGAGCAGATCACAGGG
AAGGATGTCCGGCTCCTGCGCATTAAGAAGGAGGGATCGTTAGATCTGGCCCTGGAAGGCGGTG
TGGACTCCCCGATCGGGAAGGTGGTCGTCTCGGCTGTGTATGAGGGGGGAGCTGCCGAGCGGCA
TGGTGGCATTGTGAAGGGGGATGAGGTCATGGCGATCAACGGCAAGATCGTGACGGACTACACC
CTGGCTGAGGCTGAGGCCACCCTGCAGAAGGCCTGGAGTCAGGGGGGAGACTGGATCGACCTTG
TTGTTGCTGTCTGTCCCCCCAAGGAGTACGACGATGAGCTCTCTTCTCTTCCCTCTGCAGCCGA
AAGCCCCCAGCCGGTCCGAAAGTTCCTTGAAGACCGTGCTCCCGTGCACAGACACGGCTTCCTC
CTGCAGCTGGAGCCCAGCAGCCCCCCACGGTGAAGAGGCAGGCGGGCTGCAGGGCCCTGTCTGG
CCATGCTGCATGGAGTGGCCGTCTGCTGCCCGTGCTGGCAGGTTCTTTGGACTGGTGTCTGGAG
GGCTGCACAGGGCACCACCCCGAAAGTGCCATCCAGGCCTGCTGTGGGCCACCCTGGAATTTTG
TCCTACTCAAATACCCTCCTGCTCAGGGAAGGCAAGCGGAGCCCAGTCTGTAGCATGCTCGGGA
CCTGGTGTCCTGACTCACCGCTGCTTTGAGACCTGCCACAGGTCCCATGCGGCACCCATATGAG
CAGGACAGAGCATGAGTACCATGGTCTGCTGGGCGCAGACAGTGCCTCAAACCAGCACGACGGG
CTGAGTGAGCCCAGGGGAGTACGGCCTGGATCTCCCCCCAGGGGTATCCTCAGCAAAATGTGCC
TCCCTTCCCGGGGAGCACCCCCACTCTGGGAGCCCCTGCTCCACCAGGCCCCTGTGCTTGGGCA
GAACCAGGGCAATTAAGAGGCAATGGAGCCTGGTCCAAAGAACCAGGGCTGGCCCATCAGGGTT
GTTCGTGTCGTGTTGTGACTTGTCATGGCCTGAGCCCTGCTTGGACCAAGCTGTCCTCTGTGTC
CTCTGTGCCTTCTCTCTCCTTTGGCTCCAGCTCCCAGGACAGTGTCCTCTGGGGGACACTGTGC
AGCCCAGTTTGGGGATGTGTTTCCCATTCTGTGACAGGGTTATGCTCCTGGACAGAGCTGGCGG
GTGGCCATGAACCGGTGTTTGGTGTGCCCTGCAGCCCACAGCTGGCAGTATCTGGGGCAGACCC
AAGCCTGAACTTGTTGATTTCTCTGGTACAAGTTTCTCAAAACATTAGGGCCTCATGCTCCCGA
GACACTTGACCTGCTATGCCGTGGCTCCCGGCATGGCCTCTCAATGACTCTATGTTTTCTGCCA
CTTGTCATTTGCTCCTTGGGAGGGACCCCAGACCCCCTGCCTCTGGTCCCCTCCTAGCTCATCC
CACGCATCCCTTCTGCCATCCCCAGCCTCTTGCGTGCTGTGGCTCTGGCTGTTGTGTGGCTGCT
TGAGACCTGCTTCGTGCTTCCAGGGAGGGTGTCCCCTGGGCCGAGCGTGTACCCACAAAGCCTG
CACGTGTCTGCTCTGTTTCCT

hide sequence

RefSeq Acc Id:

XM_038430637 ⟹ XP_038286565

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	21	41,161,015 - 41,205,900 (-)	NCBI

RefSeq Acc Id:

XM_038505963 ⟹ XP_038361891

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	21	40,173,714 - 40,218,550 (-)	NCBI

RefSeq Acc Id:

XM_038569185 ⟹ XP_038425113

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	21	40,719,734 - 40,764,634 (-)	NCBI

RefSeq Acc Id:

XM_038633377 ⟹ XP_038489305

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	21	40,380,893 - 40,425,786 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_013978245	(Get FASTA)	NCBI Sequence Viewer
	XP_038286565	(Get FASTA)	NCBI Sequence Viewer
	XP_038361891	(Get FASTA)	NCBI Sequence Viewer
	XP_038425113	(Get FASTA)	NCBI Sequence Viewer
	XP_038489305	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000053334.2
	ENSCAFP00030039641.1
	ENSCAFP00030039666.1
	ENSCAFP00040036009.1
	ENSCAFP00040036063.1
	ENSCAFP00845020326.1
	ENSCAFP00845020359.1
	ENSCAFP00845020376
	ENSCAFP00845020376.1

RefSeq Acc Id:

XP_013978245 ⟸ XM_014122770

- UniProtKB:

A0A8C0PCH4 (UniProtKB/TrEMBL), A0A8I3NTK1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVFVGDLKLVINEPSRLPLFDAIRP
LIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGL
QVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLKWQYVDQFVSES
EGGRSTLSFPGSRENKEKKVFISLVGSRGLGCSISSGPVQKPGIFISHVKPGSLSAEVGLEAGD
QIVEVNGIDFSNLDHKEAVNVLKSSRSLTISIVAGAGRELFLTDRERLEEARQRELQRQELLMQ
KRLAMESNKILQEQQEMERQRKKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQL
LSPKTITAEVHPIPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKTKYDSLQELRKNKKELEFEQK
LYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVERLCQTRLEQISSADNEISEMT
TGPPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPSPKI
PAPPVLSSSGRVSASSSPWVQRTPPPIPIPPPPSIPTQDLTPTRPLPSALEEALGNHPFRAGDT
GNPTEDWEAKNHSGKPTNSPVPERSFPPTPKTFCPSPQPPRGPGVSTISKPVMVHQESNFIYRP
AVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGFDPYSMFTPEQITGKDVRLLRIKKEGSLDLAL
EGGVDSPIGKVVVSAVYEGGAAERHGGIVKGDEVMAINGKIVTDYTLAEAEATLQKAWSQGGDW
IDLVVAVCPPKEYDDELSSLPSAAESPQPVRKFLEDRAPVHRHGFLLQLEPSSPPR

hide sequence

Ensembl Acc Id:

ENSCAFP00000053334 ⟸ ENSCAFT00000077248

Ensembl Acc Id:

ENSCAFP00000013248 ⟸ ENSCAFT00000014325

Ensembl Acc Id:

ENSCAFP00000013245 ⟸ ENSCAFT00000014322

RefSeq Acc Id:

XP_038361891 ⟸ XM_038505963

RefSeq Acc Id:

XP_038489305 ⟸ XM_038633377

RefSeq Acc Id:	XP_038286565 ⟸ XM_038430637
- UniProtKB:	A0A8C0PCH4 (UniProtKB/TrEMBL), A0A8I3NTK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038425113 ⟸ XM_038569185
- UniProtKB:	A0A8C0PCH4 (UniProtKB/TrEMBL), A0A8I3NTK1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845020376 ⟸ ENSCAFT00845025859

Ensembl Acc Id:

ENSCAFP00845020326 ⟸ ENSCAFT00845025797

Ensembl Acc Id:

ENSCAFP00845020359 ⟸ ENSCAFT00845025838

Protein Domains

PDZ

Promoters

RGD ID:

13687260

Promoter ID:

EPDNEW_C5327

Type:

initiation region

Name:

USH1C_1

Description:

USH1 protein network component harmonin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	21	40,100,655 - 40,100,715	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000008995	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030024648	UniProtKB/TrEMBL
	ENSCAFG00040022229	UniProtKB/TrEMBL
	ENSCAFG00845014411	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000077248.2	UniProtKB/TrEMBL
	ENSCAFT00030045395.1	UniProtKB/TrEMBL
	ENSCAFT00030045421.1	UniProtKB/TrEMBL
	ENSCAFT00040041288.1	UniProtKB/TrEMBL
	ENSCAFT00040041349.1	UniProtKB/TrEMBL
	ENSCAFT00845025797.1	UniProtKB/TrEMBL
	ENSCAFT00845025838.1	UniProtKB/TrEMBL
	ENSCAFT00845025859	ENTREZGENE
	ENSCAFT00845025859.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1160.20	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
InterPro	Harmonin	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	USH2_Complex_Protein	UniProtKB/TrEMBL
NCBI Gene	USH1C	ENTREZGENE
PANTHER	PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED	UniProtKB/TrEMBL
	PTHR23116:SF36	UniProtKB/TrEMBL
Pfam	PDZ	UniProtKB/TrEMBL
	USH1C_N	UniProtKB/TrEMBL
PRINTS	PRICHEXTENSN	UniProtKB/TrEMBL
PROSITE	PDZ	UniProtKB/TrEMBL
SMART	PDZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50156	UniProtKB/TrEMBL
UniProt	A0A8C0PCH4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0PIW6_CANLF	UniProtKB/TrEMBL
	A0A8I3NTK1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NTR0_CANLF	UniProtKB/TrEMBL
	A0A8I3NW26_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:48172	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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