HCRT (hypocretin neuropeptide precursor) - Rat Genome Database

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Gene: HCRT (hypocretin neuropeptide precursor) Canis lupus familiaris
Analyze
Symbol: HCRT
Name: hypocretin neuropeptide precursor (Ensembl:hypocretin neuropeptide)
RGD ID: 12151352
Description: ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); type 2 orexin receptor binding (ortholog); INVOLVED IN eating behavior (ortholog); excitatory postsynaptic potential (ortholog); negative regulation of DNA replication (ortholog); PARTICIPATES IN orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH cannabis dependence (ortholog); cocaine abuse (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: orexin; prepro-orexin; preprohypocretin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,729,616 - 20,732,074 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,730,779 - 20,732,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,191,816 - 20,193,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,448,985 - 21,450,877 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,449,587 - 21,450,836 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,234,894 - 20,236,143 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,501,999 - 20,503,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,605,051 - 20,606,300 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11282968   PMID:11283317   PMID:11340621   PMID:22301074   PMID:25601132   PMID:30032202  


Genomics

Comparative Map Data
HCRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,729,616 - 20,732,074 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,730,779 - 20,732,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,191,816 - 20,193,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,448,985 - 21,450,877 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,449,587 - 21,450,836 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,234,894 - 20,236,143 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,501,999 - 20,503,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,605,051 - 20,606,300 (+)NCBIUU_Cfam_GSD_1.0
HCRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,184,060 - 42,185,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,184,060 - 42,185,452 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,336,078 - 40,337,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,589,604 - 37,590,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,589,603 - 37,590,996NCBI
Celera1736,990,305 - 36,991,697 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,101,194 - 36,102,586 (-)NCBIHuRef
CHM1_11740,571,806 - 40,573,198 (-)NCBICHM1_1
T2T-CHM13v2.01743,040,552 - 43,041,944 (-)NCBIT2T-CHM13v2.0
Hcrt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,652,519 - 100,653,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,651,895 - 100,653,757 (-)EnsemblGRCm39 Ensembl
GRCm3811100,761,693 - 100,762,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,761,069 - 100,762,931 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,623,007 - 100,624,245 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,577,783 - 100,579,021 (-)NCBIMGSCv36mm8
Celera11111,378,254 - 111,379,492 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.6NCBI
Hcrt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,190,289 - 86,191,524 (-)NCBIGRCr8
mRatBN7.21085,689,979 - 85,691,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,689,465 - 85,691,210 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,726,483 - 90,727,718 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,205,335 - 90,206,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,598,213 - 85,599,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,669,216 - 88,670,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,669,214 - 88,670,430 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,463,386 - 88,464,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,699,633 - 89,700,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,714,002 - 89,715,214 (-)NCBI
Celera1084,405,435 - 84,406,649 (-)NCBICelera
Cytogenetic Map10q31NCBI
Hcrt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,235,819 - 16,237,457 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,235,819 - 16,237,457 (-)NCBIChiLan1.0ChiLan1.0
HCRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,798,659 - 22,800,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,688,821 - 24,691,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,130,581 - 15,132,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,353,203 - 15,354,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,353,203 - 15,354,594 (+)Ensemblpanpan1.1panPan2
Hcrt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,066,733 - 20,068,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,006,997 - 17,008,369 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,007,001 - 17,008,363 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,588,027 - 20,589,988 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,588,597 - 20,589,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,877,771 - 20,880,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCRT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,083,199 - 64,085,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,084,070 - 64,085,292 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,898,734 - 34,900,062 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcrt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,744,648 - 1,746,633 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,744,782 - 1,747,360 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HCRT
25 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 4 5 23 20 14 4 6 4 6 30 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000024739   ⟹   ENSCAFP00000022949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl920,730,779 - 20,732,028 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845017785   ⟹   ENSCAFP00845013852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl921,449,587 - 21,450,836 (+)Ensembl
RefSeq Acc Id: NM_001033994   ⟹   NP_001029166
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1920,730,779 - 20,732,028 (+)NCBI
Dog10K_Boxer_Tasha920,191,816 - 20,193,065 (+)NCBI
ROS_Cfam_1.0921,449,587 - 21,450,836 (+)NCBI
UMICH_Zoey_3.1920,234,894 - 20,236,143 (+)NCBI
UNSW_CanFamBas_1.0920,501,999 - 20,503,248 (+)NCBI
UU_Cfam_GSD_1.0920,605,051 - 20,606,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038675094   ⟹   XP_038531022
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0921,448,985 - 21,450,877 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001029166 (Get FASTA)   NCBI Sequence Viewer  
  XP_038531022 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG13965 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000022949.3
  ENSCAFP00030000352.1
  ENSCAFP00040013910.1
  ENSCAFP00805018868
  ENSCAFP00845013852
  ENSCAFP00845013852.1
GenBank Protein Q9GLF6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001029166   ⟸   NM_001033994
- Peptide Label: precursor
- UniProtKB: Q9GLF6 (UniProtKB/Swiss-Prot),   A0A8C0KK24 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000022949   ⟸   ENSCAFT00000024739
RefSeq Acc Id: XP_038531022   ⟸   XM_038675094
- Peptide Label: isoform X1
- UniProtKB: Q9GLF6 (UniProtKB/Swiss-Prot),   A0A8C0KK24 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013852   ⟸   ENSCAFT00845017785


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015615 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030000255 UniProtKB/Swiss-Prot
  ENSCAFG00040008609 UniProtKB/Swiss-Prot
  ENSCAFG00805013189 UniProtKB/Swiss-Prot
  ENSCAFG00845010112 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000024739.5 UniProtKB/Swiss-Prot
  ENSCAFT00030000402.1 UniProtKB/Swiss-Prot
  ENSCAFT00040016053.1 UniProtKB/Swiss-Prot
  ENSCAFT00805024011 UniProtKB/Swiss-Prot
  ENSCAFT00845017785 ENTREZGENE
  ENSCAFT00845017785.1 UniProtKB/Swiss-Prot
InterPro Orexin UniProtKB/Swiss-Prot
KEGG Report cfa:607641 UniProtKB/Swiss-Prot
NCBI Gene HCRT ENTREZGENE
PANTHER OREXIN UniProtKB/Swiss-Prot
  PTHR15173 UniProtKB/Swiss-Prot
Pfam Orexin UniProtKB/Swiss-Prot
PIRSF Orexin UniProtKB/Swiss-Prot
PRINTS OREXINPP UniProtKB/Swiss-Prot
UniProt A0A8C0KK24 ENTREZGENE
  OREX_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:41622 ENTREZGENE