PENK (proenkephalin) - Rat Genome Database

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Gene: PENK (proenkephalin) Canis lupus familiaris
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Symbol: PENK
Name: proenkephalin
RGD ID: 12124267
Description: ENCODES a protein that exhibits opioid receptor binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN aggressive behavior (ortholog); behavioral fear response (ortholog); cellular response to cAMP (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Anhedonia (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proenkephalin-A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,757,543 - 7,763,137 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,757,857 - 7,762,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha298,069,914 - 8,075,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,832,106 - 7,837,657 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1297,844,842 - 7,850,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,975,639 - 7,980,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,254,882 - 8,260,429 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PENK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,757,543 - 7,763,137 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,757,857 - 7,762,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha298,069,914 - 8,075,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,832,106 - 7,837,657 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1297,844,842 - 7,850,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,975,639 - 7,980,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,254,882 - 8,260,429 (-)NCBIUU_Cfam_GSD_1.0
PENK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,440,957 - 56,446,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl856,436,674 - 56,446,671 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,353,516 - 57,359,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,516,070 - 57,521,143 (-)NCBINCBI36Build 36hg18NCBI36
Build 34857,516,069 - 57,521,143NCBI
Celera853,344,310 - 53,350,077 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,820,608 - 52,826,373 (-)NCBIHuRef
CHM1_1857,405,395 - 57,411,158 (-)NCBICHM1_1
T2T-CHM13v2.0856,818,203 - 56,823,883 (-)NCBIT2T-CHM13v2.0
Penk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3944,133,536 - 4,138,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm39 Ensembl
GRCm3844,133,536 - 4,138,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3744,060,683 - 4,065,592 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3644,060,683 - 4,065,592 (-)NCBIMGSCv36mm8
Celera44,092,742 - 4,097,651 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.31NCBI
Penk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,981,381 - 21,987,074 (-)NCBIGRCr8
mRatBN7.2517,183,799 - 17,189,160 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl517,183,806 - 17,189,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,402,516 - 19,407,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0521,001,023 - 21,005,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,754,402 - 20,759,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0517,056,412 - 17,061,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl517,056,419 - 17,061,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,834,409 - 21,839,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,509,323 - 17,514,265 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,516,079 - 17,517,452 (-)NCBI
Celera516,529,164 - 16,534,106 (-)NCBICelera
Cytogenetic Map5q12NCBI
Penk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545415,426,017 - 15,426,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545415,425,712 - 15,426,685 (-)NCBIChiLan1.0ChiLan1.0
PENK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2772,075,726 - 72,081,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1847,800,250 - 47,806,064 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0852,864,388 - 52,870,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1850,234,170 - 50,239,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl850,234,170 - 50,239,949 (-)Ensemblpanpan1.1panPan2
Penk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530371,763,745 - 71,769,230 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364963,016,218 - 3,021,738 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364963,016,247 - 3,021,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PENK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,525,555 - 75,530,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,525,497 - 75,530,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,444,889 - 82,449,745 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PENK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,458,113 - 52,463,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,457,904 - 52,463,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,329,730 - 89,335,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Penk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,595,450 - 3,613,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,595,485 - 3,613,117 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PENK
91 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000011322   ⟹   ENSCAFP00000010492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl297,757,857 - 7,762,398 (-)Ensembl
RefSeq Acc Id: XM_038441205   ⟹   XP_038297133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0297,832,106 - 7,837,657 (-)NCBI
RefSeq Acc Id: XM_038461000   ⟹   XP_038316928
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha298,069,914 - 8,075,462 (-)NCBI
RefSeq Acc Id: XM_038515781   ⟹   XP_038371709
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1297,844,842 - 7,850,120 (-)NCBI
RefSeq Acc Id: XM_038579349   ⟹   XP_038435277
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0298,254,882 - 8,260,429 (-)NCBI
RefSeq Acc Id: XM_038643590   ⟹   XP_038499518
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0297,975,639 - 7,980,923 (-)NCBI
Ensembl Acc Id: ENSCAFP00000010492   ⟸   ENSCAFT00000011322
RefSeq Acc Id: XP_038371709   ⟸   XM_038515781
RefSeq Acc Id: XP_038499518   ⟸   XM_038643590
RefSeq Acc Id: XP_038297133   ⟸   XM_038441205
- UniProtKB: A0A8C0KPI1 (UniProtKB/TrEMBL),   A0A8P0SCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316928   ⟸   XM_038461000
- UniProtKB: A0A8C0KPI1 (UniProtKB/TrEMBL),   A0A8P0SCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435277   ⟸   XM_038579349
- UniProtKB: A0A8C0KPI1 (UniProtKB/TrEMBL),   A0A8P0SCD6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007063 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845027417 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011322.5 UniProtKB/TrEMBL
  ENSCAFT00000102796.1 UniProtKB/TrEMBL
  ENSCAFT00845048283.1 UniProtKB/TrEMBL
  ENSCAFT00845048326.1 UniProtKB/TrEMBL
  ENSCAFT00845048337.1 UniProtKB/TrEMBL
InterPro Opioid_neupept UniProtKB/TrEMBL
  Proenkphlin_A UniProtKB/TrEMBL
NCBI Gene PENK ENTREZGENE
PANTHER PTHR11438 UniProtKB/TrEMBL
  PTHR11438:SF3 UniProtKB/TrEMBL
Pfam Opiods_neuropep UniProtKB/TrEMBL
PRINTS OPIOIDPRCRSR UniProtKB/TrEMBL
  PENKAPRCRSR UniProtKB/TrEMBL
PROSITE OPIOIDS_PRECURSOR UniProtKB/TrEMBL
UniProt A0A8C0KPI1 ENTREZGENE
  A0A8I3Q1I0_CANLF UniProtKB/TrEMBL
  A0A8I3Q2I3_CANLF UniProtKB/TrEMBL
  A0A8I3S6A4_CANLF UniProtKB/TrEMBL
  A0A8P0PQS2_CANLF UniProtKB/TrEMBL
  A0A8P0SCD6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54116 ENTREZGENE