KCNB2 (potassium voltage-gated channel subfamily B member 2) - Rat Genome Database

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Gene: KCNB2 (potassium voltage-gated channel subfamily B member 2) Canis lupus familiaris
Analyze
Symbol: KCNB2
Name: potassium voltage-gated channel subfamily B member 2
RGD ID: 12122044
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity; protein heterodimerization activity (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); protein localization to plasma membrane (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); colorectal cancer (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); neuronal cell body membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: delayed rectifier potassium channel protein; potassium voltage-gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel subunit Kv2.2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12921,248,531 - 21,604,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2921,248,531 - 21,604,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2921,505,987 - 21,882,104 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02921,342,535 - 21,725,967 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2921,349,860 - 21,713,876 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12921,402,617 - 21,785,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02921,443,369 - 21,808,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02921,725,677 - 22,102,596 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:9612272   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12921,248,531 - 21,604,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2921,248,531 - 21,604,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2921,505,987 - 21,882,104 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02921,342,535 - 21,725,967 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2921,349,860 - 21,713,876 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12921,402,617 - 21,785,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02921,443,369 - 21,808,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02921,725,677 - 22,102,596 (+)NCBIUU_Cfam_GSD_1.0
KCNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38872,537,225 - 72,938,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl872,537,225 - 72,938,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37873,449,460 - 73,850,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36873,612,180 - 74,013,138 (+)NCBINCBI36Build 36hg18NCBI36
Build 34873,612,179 - 74,013,136NCBI
Celera869,452,496 - 69,847,725 (+)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef868,946,299 - 69,341,459 (+)NCBIHuRef
CHM1_1873,502,691 - 73,903,408 (+)NCBICHM1_1
T2T-CHM13v2.0872,972,288 - 73,367,350 (+)NCBIT2T-CHM13v2.0
Kcnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,357,149 - 15,793,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,357,478 - 15,793,974 (+)EnsemblGRCm39 Ensembl
GRCm38115,286,925 - 15,723,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,287,254 - 15,723,750 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,302,533 - 15,704,295 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,297,666 - 15,696,895 (+)NCBIMGSCv36mm8
MGSCv36115,858,607 - 15,860,301 (+)NCBIMGSCv36mm8
Celera115,251,474 - 15,665,920 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.5NCBI
Kcnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr858,340,085 - 8,811,184 (-)NCBIGRCr8
mRatBN7.253,567,012 - 4,028,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl53,569,685 - 4,028,599 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx55,686,237 - 6,146,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.057,325,121 - 7,785,453 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.057,023,712 - 7,485,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,975,934 - 3,430,837 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.052,965,248 - 3,418,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.452,683,952 - 3,154,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.152,683,951 - 3,154,908 (-)NCBI
Celera53,165,386 - 3,621,344 (-)NCBICelera
Cytogenetic Map5q11NCBI
Kcnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554447,237,011 - 7,646,399 (-)NCBIChiLan1.0ChiLan1.0
KCNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2788,278,471 - 88,685,017 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1863,904,517 - 64,314,700 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0869,069,427 - 69,481,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1870,756,092 - 71,123,156 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl870,756,185 - 71,122,897 (+)Ensemblpanpan1.1panPan2
Kcnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530357,711,390 - 58,087,221 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366481,361,422 - 1,734,672 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl462,879,266 - 63,307,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1462,877,838 - 63,306,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1868,165,879 - 68,538,285 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603972,849,081 - 73,253,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474418,240,912 - 18,659,530 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474418,240,321 - 18,687,157 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNB2
4359 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 21 15 5 6 5 6 31 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000012685   ⟹   ENSCAFP00000053736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2921,248,531 - 21,604,871 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845049034   ⟹   ENSCAFP00845038473
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2921,349,860 - 21,713,876 (+)Ensembl
RefSeq Acc Id: XM_038441381   ⟹   XP_038297309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02921,342,535 - 21,725,967 (+)NCBI
RefSeq Acc Id: XM_038460791   ⟹   XP_038316719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2921,505,987 - 21,882,104 (+)NCBI
RefSeq Acc Id: XM_038515959   ⟹   XP_038371887
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12921,402,617 - 21,785,087 (+)NCBI
RefSeq Acc Id: XM_038579518   ⟹   XP_038435446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02921,725,677 - 22,102,596 (+)NCBI
RefSeq Acc Id: XM_038643770   ⟹   XP_038499698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02921,443,369 - 21,808,927 (+)NCBI
Ensembl Acc Id: ENSCAFP00000053736   ⟸   ENSCAFT00000012685
RefSeq Acc Id: XP_038371887   ⟸   XM_038515959
RefSeq Acc Id: XP_038499698   ⟸   XM_038643770
RefSeq Acc Id: XP_038297309   ⟸   XM_038441381
- UniProtKB: Q95167 (UniProtKB/Swiss-Prot),   A0A8C0MN64 (UniProtKB/TrEMBL),   A0A8I3PYY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316719   ⟸   XM_038460791
- UniProtKB: Q95167 (UniProtKB/Swiss-Prot),   A0A8C0MN64 (UniProtKB/TrEMBL),   A0A8I3PYY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435446   ⟸   XM_038579518
- UniProtKB: Q95167 (UniProtKB/Swiss-Prot),   A0A8C0MN64 (UniProtKB/TrEMBL),   A0A8I3PYY4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845038473   ⟸   ENSCAFT00845049034
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007939 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007434 UniProtKB/TrEMBL
  ENSCAFG00040024195 UniProtKB/TrEMBL
  ENSCAFG00845027791 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012685.4 UniProtKB/TrEMBL
  ENSCAFT00030013631.1 UniProtKB/TrEMBL
  ENSCAFT00040045088.1 UniProtKB/TrEMBL
  ENSCAFT00845049034 ENTREZGENE
  ENSCAFT00845049034.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene KCNB2 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kv2channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV22CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0MN64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PYY4 ENTREZGENE, UniProtKB/TrEMBL
  KCNB2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:110599 ENTREZGENE