AKR7A2 (aldo-keto reductase family 7 member A2) - Rat Genome Database

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Gene: AKR7A2 (aldo-keto reductase family 7 member A2) Canis lupus familiaris
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Symbol: AKR7A2
Name: aldo-keto reductase family 7 member A2 (Ensembl:aldo-keto reductase family 7 like (gene/pseudogene))
RGD ID: 12101786
Description: ENCODES a protein that exhibits aldose reductase (NADPH) activity (ortholog); phenanthrene-9,10-epoxide hydrolase activity (ortholog); INVOLVED IN daunorubicin metabolic process (ortholog); doxorubicin metabolic process (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); Alzheimer's disease (ortholog); autism spectrum disorder (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aflatoxin B1 aldehyde reductase member 2; aflatoxin B1 aldehyde reductase member 4; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); LOC478210
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,334,179 - 79,343,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,334,205 - 79,343,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,849,105 - 75,858,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,956,898 - 79,965,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,956,898 - 79,968,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,717,803 - 76,726,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,727,438 - 77,736,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,798,535 - 78,808,663 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
AKR7A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,334,179 - 79,343,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,334,205 - 79,343,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,849,105 - 75,858,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,956,898 - 79,965,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,956,898 - 79,968,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,717,803 - 76,726,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,727,438 - 77,736,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,798,535 - 78,808,663 (+)NCBIUU_Cfam_GSD_1.0
AKR7A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,302,708 - 19,312,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,301,991 - 19,312,144 (-)EnsemblGRCh38hg38GRCh38
GRCh37119,629,202 - 19,638,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,503,046 - 19,511,227 (-)NCBINCBI36Build 36hg18NCBI36
Build 34119,375,768 - 19,383,946NCBI
Celera117,957,442 - 17,965,624 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,875,577 - 17,884,829 (-)NCBIHuRef
CHM1_1119,738,505 - 19,747,943 (-)NCBICHM1_1
T2T-CHM13v2.0119,126,242 - 19,135,681 (-)NCBIT2T-CHM13v2.0
Akr7a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394139,038,005 - 139,046,097 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4139,038,055 - 139,045,737 (+)EnsemblGRCm39 Ensembl
GRCm384139,310,720 - 139,318,786 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,310,744 - 139,318,426 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,866,659 - 138,874,701 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,582,820 - 138,590,501 (+)NCBIMGSCv36mm8
Celera4141,097,258 - 141,105,993 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.64NCBI
Akr7a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,835,589 - 156,844,127 (+)NCBIGRCr8
mRatBN7.25151,552,375 - 151,560,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,552,343 - 151,560,909 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,250,866 - 154,259,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,025,214 - 156,033,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,006,202 - 156,014,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,759,448 - 157,768,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,759,416 - 157,768,471 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,499,603 - 161,508,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,097,679 - 158,106,217 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15158,107,717 - 158,116,254 (+)NCBI
Celera5149,932,592 - 149,941,127 (+)NCBICelera
Cytogenetic Map5q36NCBI
Akr7a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554526,844 - 13,868 (-)NCBIChiLan1.0ChiLan1.0
LOC100981962
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,802,957 - 207,822,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,919,935 - 206,938,840 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,262,631 - 18,270,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,309,211 - 19,317,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,309,471 - 19,317,227 (-)Ensemblpanpan1.1panPan2
LOC101974041
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505839,740,406 - 39,748,246 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364745,565,715 - 5,573,048 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR7A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,754,174 - 77,761,667 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1677,754,172 - 77,761,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,816,268 - 71,823,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225480
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120113,234,257 - 113,242,445 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660332,916,852 - 2,925,038 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in AKR7A2
225 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000024096   ⟹   ENSCAFP00000022370
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl279,334,205 - 79,343,007 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845006155   ⟹   ENSCAFP00845004899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl279,956,898 - 79,968,886 (+)Ensembl
RefSeq Acc Id: XM_038463897   ⟹   XP_038319825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha275,849,169 - 75,858,155 (+)NCBI
RefSeq Acc Id: XM_038470924   ⟹   XP_038326852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1276,717,803 - 76,726,853 (+)NCBI
RefSeq Acc Id: XM_038470925   ⟹   XP_038326853
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1276,717,870 - 76,726,853 (+)NCBI
RefSeq Acc Id: XM_038531795   ⟹   XP_038387723
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0278,798,535 - 78,808,663 (+)NCBI
RefSeq Acc Id: XM_038531796   ⟹   XP_038387724
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0278,798,602 - 78,808,663 (+)NCBI
RefSeq Acc Id: XM_038596051   ⟹   XP_038451979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0277,727,438 - 77,736,710 (+)NCBI
RefSeq Acc Id: XM_038596052   ⟹   XP_038451980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0277,727,502 - 77,736,710 (+)NCBI
RefSeq Acc Id: XM_038660137   ⟹   XP_038516065
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0279,956,898 - 79,965,951 (+)NCBI
RefSeq Acc Id: XM_038660138   ⟹   XP_038516066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0279,956,962 - 79,965,951 (+)NCBI
RefSeq Acc Id: XM_535385   ⟹   XP_535385
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1279,334,179 - 79,343,880 (+)NCBI
Dog10K_Boxer_Tasha275,849,105 - 75,858,155 (+)NCBI
Sequence:
RefSeq Acc Id: XP_535385   ⟸   XM_535385
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RRE1 (UniProtKB/TrEMBL),   A0A8P0SJQ6 (UniProtKB/TrEMBL),   A0A8C0ML93 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000022370   ⟸   ENSCAFT00000024096
RefSeq Acc Id: XP_038326852   ⟸   XM_038470924
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038326853   ⟸   XM_038470925
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451979   ⟸   XM_038596051
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451980   ⟸   XM_038596052
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038516065   ⟸   XM_038660137
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RRE1 (UniProtKB/TrEMBL),   A0A8P0SJQ6 (UniProtKB/TrEMBL),   A0A8C0ML93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516066   ⟸   XM_038660138
- Peptide Label: isoform X2
- UniProtKB: A0A8C0ML93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319825   ⟸   XM_038463897
- Peptide Label: isoform X2
- UniProtKB: A0A8C0ML93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387723   ⟸   XM_038531795
- Peptide Label: isoform X1
- UniProtKB: A0A8C0ML93 (UniProtKB/TrEMBL),   A0A8I3RRE1 (UniProtKB/TrEMBL),   A0A8P0SJQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387724   ⟸   XM_038531796
- Peptide Label: isoform X2
- UniProtKB: A0A8C0ML93 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845004899   ⟸   ENSCAFT00845006155

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015181 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008380 UniProtKB/TrEMBL
  ENSCAFG00040000345 UniProtKB/TrEMBL
  ENSCAFG00845003459 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024096.7 UniProtKB/TrEMBL
  ENSCAFT00030015449.1 UniProtKB/TrEMBL
  ENSCAFT00040000588.1 UniProtKB/TrEMBL
  ENSCAFT00845006155 ENTREZGENE
  ENSCAFT00845006155.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR_Detox_Biosynth UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC478210 ENTREZGENE
PANTHER NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN UniProtKB/TrEMBL
  NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A8C0ML93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RRE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SJQ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 AKR7A2  aldo-keto reductase family 7 member A2  LOC478210  aflatoxin B1 aldehyde reductase member 4  Symbol and/or name change 5135510 APPROVED