PCLO (piccolo presynaptic cytomatrix protein) - Rat Genome Database

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Gene: PCLO (piccolo presynaptic cytomatrix protein) Canis lupus familiaris
Analyze
Symbol: PCLO
Name: piccolo presynaptic cytomatrix protein
RGD ID: 12096034
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent phospholipid binding (ortholog); profilin binding (ortholog); INVOLVED IN cytoskeleton organization (ortholog); insulin secretion (ortholog); modulation of excitatory postsynaptic potential (ortholog); ASSOCIATED WITH CHARGE syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); cone cell pedicle (ortholog); cytoskeleton of presynaptic active zone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC111090913; protein piccolo; protein piccolo-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11822,385,102 - 22,701,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1822,385,100 - 22,706,793 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,995,716 - 22,385,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01822,770,098 - 23,160,278 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1822,770,852 - 22,983,764 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11822,405,472 - 22,795,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01821,940,459 - 22,330,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01822,596,545 - 22,986,291 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PCLO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11822,385,102 - 22,701,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1822,385,100 - 22,706,793 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,995,716 - 22,385,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01822,770,098 - 23,160,278 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1822,770,852 - 22,983,764 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11822,405,472 - 22,795,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01821,940,459 - 22,330,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01822,596,545 - 22,986,291 (-)NCBIUU_Cfam_GSD_1.0
PCLO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38782,754,012 - 83,162,884 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl782,754,012 - 83,162,930 (-)EnsemblGRCh38hg38GRCh38
GRCh37782,383,328 - 82,792,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36782,225,378 - 82,630,133 (-)NCBINCBI36Build 36hg18NCBI36
Build 34782,188,346 - 82,224,200NCBI
Celera777,083,829 - 77,492,761 (-)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef776,984,730 - 77,393,999 (-)NCBIHuRef
CHM1_1782,313,403 - 82,722,210 (-)NCBICHM1_1
T2T-CHM13v2.0784,005,231 - 84,414,103 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2781,715,437 - 82,124,409 (-)NCBI
Pclo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39514,564,924 - 14,913,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl514,564,932 - 14,913,473 (+)EnsemblGRCm39 Ensembl
GRCm38514,514,906 - 14,863,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl514,514,918 - 14,863,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37514,514,918 - 14,863,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36514,520,924 - 14,801,999 (+)NCBIMGSCv36mm8
Celera1224,890,712 - 25,239,859 (+)NCBICelera
Cytogenetic Map5A1- A2NCBI
cM Map56.27NCBI
Pclo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8420,646,604 - 21,005,171 (-)NCBIGRCr8
mRatBN7.2419,691,439 - 20,050,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl419,695,315 - 20,049,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx424,865,942 - 25,222,133 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0420,697,245 - 21,053,987 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0419,078,298 - 19,437,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0416,454,904 - 17,058,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl416,454,904 - 17,058,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0416,428,814 - 16,661,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0416,923,700 - 17,031,648 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4415,911,051 - 16,269,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1415,911,050 - 16,269,090 (-)NCBI
Celera415,219,539 - 15,569,109 (-)NCBICelera
Cytogenetic Map4q12NCBI
Pclo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554103,152,202 - 3,292,920 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554102,998,345 - 3,334,056 (+)NCBIChiLan1.0ChiLan1.0
PCLO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26100,601,124 - 101,013,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17148,865,761 - 149,278,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0774,714,364 - 75,126,518 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1788,378,218 - 88,789,302 (-)NCBIpanpan1.1PanPan1.1panPan2
Pclo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511864,071,317 - 64,473,183 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367341,277,591 - 1,479,521 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367341,273,055 - 1,674,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCLO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl997,114,511 - 97,513,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1997,114,503 - 97,513,081 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29107,331,780 - 107,730,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCLO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12165,729,762 - 66,129,806 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604237,825,087 - 38,233,533 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pclo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473931,143,872 - 31,448,524 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PCLO
3587 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000010157   ⟹   ENSCAFP00000009423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1822,385,100 - 22,706,793 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000073667   ⟹   ENSCAFP00000049612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1822,385,100 - 22,706,793 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047574   ⟹   ENSCAFP00845037331
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1822,770,852 - 22,983,764 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047674   ⟹   ENSCAFP00845037409
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1822,770,852 - 22,983,764 (-)Ensembl
RefSeq Acc Id: XM_038423930   ⟹   XP_038279858
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01822,770,098 - 23,160,278 (-)NCBI
RefSeq Acc Id: XM_038453861   ⟹   XP_038309789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1821,995,716 - 22,385,731 (-)NCBI
RefSeq Acc Id: XM_038453862   ⟹   XP_038309790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1822,088,661 - 22,385,731 (-)NCBI
RefSeq Acc Id: XM_038500292   ⟹   XP_038356220
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11822,405,472 - 22,795,049 (-)NCBI
RefSeq Acc Id: XM_038562845   ⟹   XP_038418773
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01822,596,545 - 22,986,291 (-)NCBI
RefSeq Acc Id: XM_038562846   ⟹   XP_038418774
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01822,689,783 - 22,986,291 (-)NCBI
RefSeq Acc Id: XM_038626966   ⟹   XP_038482894
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01821,940,459 - 22,330,520 (-)NCBI
RefSeq Acc Id: XM_038626967   ⟹   XP_038482895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01822,033,822 - 22,330,520 (-)NCBI
Ensembl Acc Id: ENSCAFP00000009423   ⟸   ENSCAFT00000010157
Ensembl Acc Id: ENSCAFP00000049612   ⟸   ENSCAFT00000073667
RefSeq Acc Id: XP_038356220   ⟸   XM_038500292
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038482894   ⟸   XM_038626966
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038482895   ⟸   XM_038626967
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038279858   ⟸   XM_038423930
- Peptide Label: isoform X1
- UniProtKB: A0A8P0T2D6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038309789   ⟸   XM_038453861
- Peptide Label: isoform X1
- UniProtKB: A0A8P0PN08 (UniProtKB/TrEMBL),   A0A8P0T2D6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038309790   ⟸   XM_038453862
- Peptide Label: isoform X4
- UniProtKB: A0A8P0N8U4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418773   ⟸   XM_038562845
- Peptide Label: isoform X1
- UniProtKB: A0A8P0T2D6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418774   ⟸   XM_038562846
- Peptide Label: isoform X3
- UniProtKB: A0A8P0N8U4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845037409   ⟸   ENSCAFT00845047674
Ensembl Acc Id: ENSCAFP00845037331   ⟸   ENSCAFT00845047574
Protein Domains
C2   PDZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006264 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845026971 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010157.5 UniProtKB/TrEMBL
  ENSCAFT00000073667.2 UniProtKB/TrEMBL
  ENSCAFT00000098956.1 UniProtKB/TrEMBL
  ENSCAFT00000107794.1 UniProtKB/TrEMBL
  ENSCAFT00845047574.1 UniProtKB/TrEMBL
  ENSCAFT00845047674.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  PCLO_FYVE1 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Presynaptic_Scaffold_Bsn/Pclo UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_piccolo UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene PCLO ENTREZGENE
PANTHER PICCOLO/BASSOON UniProtKB/TrEMBL
  PTHR14113:SF6 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  zf-piccolo UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
  SYNAPTOTAGMN UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP FYVE/PHD zinc finger UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A8I3PTC9_CANLF UniProtKB/TrEMBL
  A0A8I3PUX6_CANLF UniProtKB/TrEMBL
  A0A8P0N8U4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PGY1_CANLF UniProtKB/TrEMBL
  A0A8P0PN08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T2D6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:58325 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 PCLO  piccolo presynaptic cytomatrix protein  LOC111090913  protein piccolo-like  Data merged from RGD:13393260 737654 PROVISIONAL