SLC11A1 (solute carrier family 11 member 1) - Rat Genome Database

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Pathways
Gene: SLC11A1 (solute carrier family 11 member 1) Canis lupus familiaris
Analyze
Symbol: SLC11A1
Name: solute carrier family 11 member 1
RGD ID: 12095488
Description: ENCODES a protein that exhibits iron ion transmembrane transporter activity (ortholog); manganese ion transmembrane transporter activity (ortholog); metal cation:proton antiporter activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); iron ion transport (ortholog); manganese ion transport (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); alacrima, achalasia, and impaired intellectual development syndrome (ortholog); asthma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); late endosome (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: natural resistance-associated macrophage protein 1; NRAMP 1; NRAMP1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,039,203 - 25,047,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,038,360 - 25,047,282 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3725,859,294 - 25,867,379 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,054,994 - 25,063,083 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,053,097 - 25,063,084 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,960,561 - 24,968,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,894,238 - 24,902,300 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,914,545 - 24,922,623 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
antigen processing and presentation of peptide antigen  (IEA)
cadmium ion transmembrane transport  (IEA)
cellular detoxification of cadmium ion  (IEA)
defense response to bacterium  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to protozoan  (IEA)
establishment of localization in cell  (IEA)
inflammatory response  (IEA)
intracellular iron ion homeostasis  (IBA,IEA)
intracellular manganese ion homeostasis  (IBA)
iron ion transmembrane transport  (IBA,IEA)
iron ion transport  (IEA,ISS)
L-arginine transmembrane transport  (IEA)
macrophage activation  (IEA)
manganese ion transmembrane transport  (IEA)
manganese ion transport  (IBA,IEA,ISO,ISS,NAS)
MAPK cascade  (ISO)
metal ion transport  (IEA)
MHC class II biosynthetic process  (IEA)
monoatomic ion transport  (IEA)
mRNA stabilization  (IEA)
multicellular organismal-level iron ion homeostasis  (IEA)
negative regulation of cytokine production  (IEA)
nitrite transport  (IEA)
phagocytosis  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of dendritic cell antigen processing and presentation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of type II interferon production  (IEA)
proton transmembrane transport  (IEA)
respiratory burst  (IEA)
response to bacterium  (IEA)
response to lipopolysaccharide  (IEA)
response to type II interferon  (IEA)
T cell proliferation involved in immune response  (IEA)
vacuolar acidification  (IEA)
wound healing  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:12010961   PMID:16251521   PMID:18307968   PMID:19084282   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC11A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,039,203 - 25,047,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,038,360 - 25,047,282 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3725,859,294 - 25,867,379 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,054,994 - 25,063,083 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,053,097 - 25,063,084 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,960,561 - 24,968,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,894,238 - 24,902,300 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,914,545 - 24,922,623 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SLC11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,382,273 - 218,396,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,382,029 - 218,396,894 (+)Ensemblhg38GRCh38
GRCh372219,246,996 - 219,261,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,954,996 - 218,969,861 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342219,072,421 - 219,086,002NCBI
Celera2213,013,369 - 213,028,238 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,100,043 - 211,114,917 (+)NCBIHuRef
CHM1_12219,253,406 - 219,268,272 (+)NCBICHM1_1
T2T-CHM13v2.02218,868,403 - 218,883,023 (+)NCBIT2T-CHM13v2.0
Slc11a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,414,318 - 74,429,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,414,354 - 74,425,221 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38174,375,014 - 74,386,057 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,375,195 - 74,386,062 (+)Ensemblmm10GRCm38
MGSCv37174,421,777 - 74,432,625 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36174,308,436 - 74,319,269 (+)NCBIMGSCv36mm8
Celera174,932,506 - 74,943,551 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.54NCBI
Slc11a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,406,327 - 83,417,252 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,406,427 - 83,417,238 (+)EnsemblGRCr8
mRatBN7.2975,957,193 - 75,968,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,957,316 - 75,968,101 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,402,352 - 84,413,166 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,531,293 - 89,542,107 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,917,487 - 87,928,297 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,655,590 - 81,666,697 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,655,629 - 81,666,706 (+)Ensemblrn6Rnor6.0
Rnor_5.0981,420,556 - 81,431,345 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4973,714,692 - 73,725,523 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera973,531,012 - 73,541,597 (+)NCBICelera
Cytogenetic Map9q33NCBI
Slc11a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,980,562 - 14,995,608 (-)Ensembl
ChiLan1.0NW_00495545314,980,562 - 14,995,118 (-)NCBIChiLan1.0ChiLan1.0
SLC11A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,013,434 - 121,028,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,028,394 - 121,041,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,640,613 - 105,655,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,238,284 - 224,252,941 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,238,284 - 224,252,941 (+)EnsemblpanPan2panpan1.1
Slc11a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,544,696 - 174,553,261 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569887,742 - 895,977 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936569888,309 - 895,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC11A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,433,952 - 120,446,396 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115120,434,100 - 120,446,396 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,452,820 - 133,454,896 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC11A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,276,553 - 104,288,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604095,112,392 - 95,128,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc11a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,612,452 - 6,625,300 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248236,612,452 - 6,625,047 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC11A1
146 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023259   ⟹   ENSCAFP00000021599
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3725,038,360 - 25,047,282 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845047751   ⟹   ENSCAFP00845037468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3725,053,097 - 25,063,084 (+)Ensembl
RefSeq Acc Id: NM_001013851   ⟹   NP_001013873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13725,039,203 - 25,047,461 (+)NCBI
Dog10K_Boxer_Tasha3725,859,294 - 25,867,379 (+)NCBI
ROS_Cfam_1.03725,054,994 - 25,063,083 (+)NCBI
UMICH_Zoey_3.13724,960,561 - 24,968,638 (+)NCBI
UNSW_CanFamBas_1.03724,894,238 - 24,902,300 (+)NCBI
UU_Cfam_GSD_1.03724,914,545 - 24,922,623 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001013873 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD37483 (Get FASTA)   NCBI Sequence Viewer  
  ABG78262 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00845037468
GenBank Protein Q9XT74 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013873   ⟸   NM_001013851
- UniProtKB: Q0PPT4 (UniProtKB/Swiss-Prot),   Q9XT74 (UniProtKB/Swiss-Prot),   A0A8C0TM07 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021599   ⟸   ENSCAFT00000023259
Ensembl Acc Id: ENSCAFP00845037468   ⟸   ENSCAFT00845047751

Promoters
RGD ID:13689150
Promoter ID:EPDNEW_C7217
Type:initiation region
Name:SLC11A1_1
Description:solute carrier family 11 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13725,038,380 - 25,038,440EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014645 Ensembl
  ENSCAFG00845027087 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845047751 ENTREZGENE
InterPro NRAMP_fam UniProtKB/Swiss-Prot
KEGG Report cfa:478909 UniProtKB/Swiss-Prot
NCBI Gene SLC11A1 ENTREZGENE
PANTHER NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR11706 UniProtKB/Swiss-Prot
Pfam Nramp UniProtKB/Swiss-Prot
PRINTS NATRESASSCMP UniProtKB/Swiss-Prot
UniProt A0A8C0RRH3_CANLF UniProtKB/TrEMBL
  A0A8C0TM07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QCU8_CANLF UniProtKB/TrEMBL
  A0A8P0PK60_CANLF UniProtKB/TrEMBL
  NRAM1_CANLF UniProtKB/Swiss-Prot
  Q0PPT4 ENTREZGENE
  Q9XT74 ENTREZGENE
UniProt Secondary Q0PPT4 UniProtKB/Swiss-Prot
VGNC ID VGNC:46216 ENTREZGENE