AKR1B1 (aldo-keto reductase family 1 member B) - Rat Genome Database

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Gene: AKR1B1 (aldo-keto reductase family 1 member B) Canis lupus familiaris
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Symbol: AKR1B1
Name: aldo-keto reductase family 1 member B
RGD ID: 12092288
Description: ENCODES a protein that exhibits aldose reductase (NADPH) activity (ortholog); cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity (ortholog); glyceraldehyde oxidoreductase activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to methylglyoxal (ortholog); PARTICIPATES IN D-glycericacidemia pathway; dopa responsive dystonia pathway; familial lipoprotein lipase deficiency pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Albuminuria (ortholog); allergic disease (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); mast cell granule (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); aldose reductase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC482334  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,991,888 - 3,006,941 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,991,888 - 3,006,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,649,050 - 2,664,066 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,721,426 - 2,736,482 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,721,426 - 2,736,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,926,088 - 2,941,099 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,670,903 - 2,685,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,816,445 - 2,831,531 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
AKR1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,991,888 - 3,006,941 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,991,888 - 3,006,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,649,050 - 2,664,066 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,721,426 - 2,736,482 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,721,426 - 2,736,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,926,088 - 2,941,099 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,670,903 - 2,685,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,816,445 - 2,831,531 (+)NCBIUU_Cfam_GSD_1.0
AKR1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,442,350 - 134,459,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,442,356 - 134,459,284 (-)EnsemblGRCh38hg38GRCh38
GRCh377134,127,102 - 134,143,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,777,647 - 133,794,428 (-)NCBINCBI36Build 36hg18NCBI36
Build 347133,584,361 - 133,601,143NCBI
Celera7128,864,507 - 128,881,287 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,428,754 - 128,445,534 (-)NCBIHuRef
CHM1_17134,061,391 - 134,078,169 (-)NCBICHM1_1
T2T-CHM13v2.07135,750,388 - 135,767,276 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,471,421 - 133,488,201 (-)NCBI
Akr1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,280,865 - 34,294,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,279,369 - 34,294,413 (-)EnsemblGRCm39 Ensembl
GRCm38634,303,930 - 34,317,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,302,434 - 34,317,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,253,930 - 34,267,489 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,234,092 - 34,247,629 (-)NCBIMGSCv36mm8
Celera634,300,847 - 34,314,402 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.87NCBI
Akr1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,899,222 - 63,913,315 (-)NCBIGRCr8
mRatBN7.2462,932,033 - 62,946,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,932,031 - 62,946,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,882,584 - 67,896,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,798,307 - 63,812,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,200,710 - 62,214,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,706,866 - 61,720,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,706,864 - 61,720,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,426,190 - 61,440,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,645,438 - 61,659,530 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1461,921,567 - 61,935,660 (-)NCBI
Celera457,984,561 - 57,998,653 (-)NCBICelera
RH 3.4 Map4393.32RGD
Cytogenetic Map4q22NCBI
AKR1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26171,258,419 - 171,275,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1723,268,674 - 23,285,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,400,861 - 126,417,756 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,907,448 - 138,924,317 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,912,953 - 138,924,095 (-)Ensemblpanpan1.1panPan2
Akr1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511821,179,563 - 21,195,800 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365791,312,175 - 1,328,397 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1814,684,036 - 14,752,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11814,593,516 - 14,752,316 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21815,596,806 - 15,614,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103226928
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121103,060,018 - 103,076,844 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21103,059,991 - 103,077,341 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666042271,394 - 288,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in AKR1B1
211 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000002002   ⟹   ENSCAFP00000001850
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl142,991,888 - 3,006,940 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845026019   ⟹   ENSCAFP00845020514
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl142,721,426 - 2,736,481 (+)Ensembl
RefSeq Acc Id: NM_001252416   ⟹   NP_001239345
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1142,991,888 - 3,006,941 (+)NCBI
Dog10K_Boxer_Tasha142,649,050 - 2,664,066 (+)NCBI
ROS_Cfam_1.0142,721,426 - 2,736,482 (+)NCBI
UMICH_Zoey_3.1142,926,088 - 2,941,099 (+)NCBI
UNSW_CanFamBas_1.0142,670,903 - 2,685,919 (+)NCBI
UU_Cfam_GSD_1.0142,816,445 - 2,831,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038685953   ⟹   XP_038541881
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0142,721,847 - 2,736,482 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001239345 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541881 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000001850.3
  ENSCAFP00030020205.1
  ENSCAFP00040008482.1
  ENSCAFP00845020514
  ENSCAFP00845020514.1
RefSeq Acc Id: NP_001239345   ⟸   NM_001252416
- UniProtKB: A0A8C0RIR1 (UniProtKB/TrEMBL),   A0A8I3P2L6 (UniProtKB/TrEMBL),   A0A8C0Q4H8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001850   ⟸   ENSCAFT00000002002
RefSeq Acc Id: XP_038541881   ⟸   XM_038685953
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCAFP00845020514   ⟸   ENSCAFT00845026019
Promoters
RGD ID:13685694
Promoter ID:EPDNEW_C3763
Type:initiation region
Name:AKR1B1_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1142,991,902 - 2,991,962EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001290 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012503 UniProtKB/TrEMBL
  ENSCAFG00040005220 UniProtKB/TrEMBL
  ENSCAFG00845014537 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002002.6 UniProtKB/TrEMBL
  ENSCAFT00030023166.1 UniProtKB/TrEMBL
  ENSCAFT00040009790.1 UniProtKB/TrEMBL
  ENSCAFT00845026019 ENTREZGENE
  ENSCAFT00845026019.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:607537 UniProtKB/TrEMBL
NCBI Gene AKR1B1 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A8C0Q4H8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RIR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P2L6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111874 ENTREZGENE