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Gene: CRYAA (crystallin alpha A) Pan paniscus

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Symbol:

CRYAA

Name:

crystallin alpha A

RGD ID:

12023631

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple types (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

alpha-crystallin A chain; alpha-crystallin A2 chain; crystallin, alpha A; LOC100973228; LOC106634229; uncharacterized LOC106634229

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRYAA (crystallin alpha A)	NCBI	Ortholog
Mus musculus (house mouse):	Cryaa (crystallin, alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cryaa (crystallin, alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cryaa (crystallin alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRYAA (crystallin alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cryaa (crystallin alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRYAA (crystallin alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cryaa (crystallin alpha A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	39,162,843 - 39,229,463 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	34,015,834 - 34,082,195 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	29,414,308 - 29,480,655 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	42,722,116 - 42,750,290 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	42,782,991 - 42,786,794 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune disease (ISO)

cataract (ISO)

cataract 9 multiple types (ISO)

Cataract, Autosomal Recessive Congenital 1 (ISO)

developmental and epileptic encephalopathy 30 (ISO)

Eye Abnormalities (ISO)

galactosemia (ISO)

genetic disease (ISO)

globe disease (ISO)

homocystinuria (ISO)

ocular hypertension (ISO)

primary ciliary dyskinesia (ISO)

progressive myoclonus epilepsy (ISO)

uveitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (ISO)

apoptotic process (ISO)

apoptotic process involved in morphogenesis (ISO)

camera-type eye development (ISO)

embryonic camera-type eye morphogenesis (ISO)

lens development in camera-type eye (IEA,ISO)

lens fiber cell morphogenesis (ISO)

lens morphogenesis in camera-type eye (ISO)

microtubule-based process (ISO)

mitochondrion organization (ISO)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of gene expression (ISO)

negative regulation of intracellular transport (IEA)

positive regulation of cell growth (ISO)

positive regulation of protein phosphorylation (ISO)

protein folding (ISO)

protein refolding (IEA)

protein stabilization (IEA)

response to glucocorticoid (ISO)

response to heat (IEA)

response to hydrogen peroxide (ISO)

response to hypoxia (ISO)

response to lead ion (ISO)

response to UV-A (ISO)

response to xenobiotic stimulus (ISO)

tubulin complex assembly (ISO)

visual perception (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IEA)

protein-containing complex (IEA)

Molecular Function

identical protein binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

structural constituent of eye lens (IEA)

structural molecule activity (IEA)

unfolded protein binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CRYAA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	39,162,843 - 39,229,463 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	34,015,834 - 34,082,195 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	29,414,308 - 29,480,655 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	42,722,116 - 42,750,290 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	42,782,991 - 42,786,794 (+)	Ensembl	panpan1.1		panPan2

CRYAA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	43,169,008 - 43,172,810 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	43,169,008 - 43,172,810 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	44,589,118 - 44,592,920 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	43,462,210 - 43,465,982 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	43,462,209 - 43,465,982	NCBI
Celera	21	29,741,819 - 29,745,592 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	30,007,222 - 30,011,008 (+)	NCBI		HuRef
CHM1_1	21	44,149,981 - 44,153,753 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	41,560,102 - 41,563,905 (+)	NCBI		T2T-CHM13v2.0

Cryaa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	31,896,905 - 31,900,704 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	31,896,781 - 31,900,707 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	31,677,931 - 31,681,730 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	31,677,807 - 31,681,733 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	31,814,890 - 31,818,669 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	31,406,661 - 31,410,057 (+)	NCBI		MGSCv36	mm8
Celera	17	32,595,462 - 32,599,241 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.09	NCBI

Cryaa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	9,784,872 - 9,788,656 (+)	NCBI		GRCr8
mRatBN7.2	20	9,783,605 - 9,787,351 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	9,783,605 - 9,787,349 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	10,485,297 - 10,489,042 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	9,846,484 - 9,850,229 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	10,315,168 - 10,318,913 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	10,438,444 - 10,442,189 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	10,438,444 - 10,442,187 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	12,621,549 - 12,625,628 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	11,297,259 - 11,301,004 (+)	NCBI		Celera
RH 3.4 Map	20	134.02	RGD
Cytogenetic Map	20	p12	NCBI

Cryaa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	38,880,086 - 38,925,642 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	38,880,088 - 38,892,946 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRYAA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	37,307,070 - 37,310,262 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	37,307,093 - 37,310,247 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	36,462,427 - 36,465,619 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	36,850,477 - 36,853,680 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	36,850,500 - 36,853,665 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	36,719,304 - 36,722,496 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	36,704,182 - 36,707,379 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	37,196,540 - 37,199,740 (+)	NCBI		UU_Cfam_GSD_1.0

Cryaa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	36,532,632 - 36,536,019 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	931,754 - 935,296 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	931,804 - 935,185 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRYAA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	206,293,849 - 206,297,015 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	206,293,877 - 206,297,050 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Cryaa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	27,637,267 - 27,639,371 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	27,636,932 - 27,639,814 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_024927030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063601264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008622443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008622444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010111061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000045688 ⟹ ENSPPAP00000022874

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	21	42,782,991 - 42,786,794 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000045691 ⟹ ENSPPAP00000022877

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	21	42,784,319 - 42,786,268 (+)	Ensembl

RefSeq Acc Id:

XM_024927030 ⟹ XP_024782798

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	22	39,226,556 - 39,229,463 (+)	NCBI
NHGRI_mPanPan1	21	34,079,288 - 34,082,195 (+)	NCBI
Mhudiblu_PPA_v0	21	29,477,783 - 29,480,655 (+)	NCBI

Sequence:

show sequence

CATTCCACAGGCGGAGTCCAGCCAGCCAGCCAAGCATCACCAGCCAGACGATTGACCCTAACGG
ACCAACCAACCCGTAACGACCCCTCCTACCATAACCAGTAGCCAGCCAGCCCATAACCAGCCAA
CCGATCTATAACCAGCCACCTGACCATAGCCAAACAACCAGCCAGCCCACCAGTAGCATTCAGC
CCCTCAGCTGGCCCTGAGGGTTTGGAGACAGGTCGAGGGTCATGCCTGTCTGTCCAGGAGACAG
CCACAGGCCCCCGAAAGCTCTGCCCCACTTGGTGTGTGGGAGAAGAGGCCGGCAGGTTCGATCC
GACCGGGACAAGTTCGTCATCTTCCTCGATGTGAAGCACTTCTCCCCGGAGGACCTCACCGTGA
AGGTGCAGGACGACTTTGTGGAGATCCACGGAAAGCACAACGAGCGCCAGGATGACCACGGCTA
CATTTCCCGTGAGTTCCACCGCCGCTACCGCCTGCCGTCCAACGTGGACCAGTCGGCCCTCTCT
TGCTCCCTGTCCGCCGATGGCATGCTGACCTTCTGTGGCCCCAAGATCCAGACTGGCCTGGATG
CCACCCACGCCGAGCGAGCCATCCCCGTGTCGCGGGAGGAGAAGCCCACCTCGGCTCCCTCGTC
CTAAGCAGGCATCGCCTCGGCTGGCTCCCCTGCAGCCCTGGCCTATCATGGGGGGAGCACCCTG
AGGGCGGGGTGTCTGTCTTCCTTTGCTTCCCTGTTTTTCCTTTCCACCTTCTCACATGGAATGA
GGGTTTGAGAGAGCAACCAGGAGAGCTTAGGGTCTCAGGGTGTCCCAGACCCCGACACCGGCCA
GTGGCGGAAGTGACCGCACCTCACACTCCTTTAGATAGCAGCCTGGCTCCCCTGGGGTGCAGGC
GCCTCAACTCTGCTGAGGGTCCAGAAGGAGGGGGTGACCTCTGGCCAGGTGCCTCCCGACACAC
CTGCAGCCTCCCTCCGCGGCGGGCCCTGCCCACACCTCCTGGGGCGCGTGGGGCCCGTGGGGCC
GGGGCTTCTGTGCACCTGGGCTCTCGTGGCCTCTTCTCTCAGACCGTCTTCCTCCAACCCCTCT
ATGTAGTGCCGCTCTTGGGGACATGGGTCGCCCATGAGAGCGCAGCCCGCGGCAATCAATAAAG
AGCAGGTGATACAAGCAA

hide sequence

RefSeq Acc Id:

XM_063601264 ⟹ XP_063457334

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	22	39,163,235 - 39,229,463 (+)	NCBI

RefSeq Acc Id:

XR_008622443

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	22	39,162,843 - 39,202,653 (+)	NCBI
NHGRI_mPanPan1	21	34,015,834 - 34,055,307 (+)	NCBI

RefSeq Acc Id:

XR_008622444

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	22	39,163,109 - 39,202,653 (+)	NCBI
NHGRI_mPanPan1	21	34,015,834 - 34,055,307 (+)	NCBI

RefSeq Acc Id:

XR_010111061

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	22	39,163,235 - 39,202,653 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_024782798	(Get FASTA)	NCBI Sequence Viewer
	XP_063457334	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000022874.1
	ENSPPAP00000022877.1

RefSeq Acc Id:	XP_024782798 ⟸ XM_024927030
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9B3Z2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPVCPGDSHRPPKALPHLVCGRRGRQVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHN ERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREE KPTSAPSS hide sequence

Ensembl Acc Id:

ENSPPAP00000022877 ⟸ ENSPPAT00000045691

Ensembl Acc Id:

ENSPPAP00000022874 ⟸ ENSPPAT00000045688

RefSeq Acc Id:	XP_063457334 ⟸ XM_063601264
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9AZW0 (UniProtKB/TrEMBL)

Protein Domains

sHSP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034607	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000045688.1	UniProtKB/TrEMBL
	ENSPPAT00000045691.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.790	UniProtKB/TrEMBL
InterPro	A-crystallin/Hsp20_dom	UniProtKB/TrEMBL
	Alpha-crystallin/sHSP_animal	UniProtKB/TrEMBL
	Alpha-crystallin_N	UniProtKB/TrEMBL
	HSP20-like_chaperone	UniProtKB/TrEMBL
NCBI Gene	LOC106634229	ENTREZGENE
PANTHER	PTHR45640	UniProtKB/TrEMBL
	PTHR45640:SF14	UniProtKB/TrEMBL
Pfam	Crystallin	UniProtKB/TrEMBL
	HSP20	UniProtKB/TrEMBL
PIRSF	Sm_HSP_B1	UniProtKB/TrEMBL
PRINTS	ACRYSTALLIN	UniProtKB/TrEMBL
PROSITE	SHSP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49764	UniProtKB/TrEMBL
UniProt	A0A2R9AZW0	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9B3Z2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-05-02	CRYAA	crystallin alpha A	LOC106634229	alpha-crystallin A2 chain	Symbol and/or name change	5135510	APPROVED
2020-07-01	LOC106634229	alpha-crystallin A2 chain	LOC106634229	uncharacterized LOC106634229	Symbol and/or name change	5135510	APPROVED
2020-06-11	LOC106634229	uncharacterized LOC106634229	LOC100973228	alpha-crystallin A chain	Data merged from RGD:11962130	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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