SPEN (spen family transcriptional repressor) - Rat Genome Database
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Gene: SPEN (spen family transcriptional repressor) Pan paniscus
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Symbol: SPEN
Name: spen family transcriptional repressor
RGD ID: 12018791
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); RNA polymerase II transcription factor binding (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); negative regulation of transcription, DNA-templated (ortholog); positive regulation of neurogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH breast ductal carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: spen homolog, transcriptional regulator
Orthologs:
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Mus musculus (house mouse) : Spen (spen family transcription repressor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spen (spen family transcriptional repressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spen (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Sus scrofa (pig) : SPEN (spen family transcriptional repressor)
Chlorocebus sabaeus (African green monkey) : SPEN (spen family transcriptional repressor)
Heterocephalus glaber (naked mole-rat) : Spen (spen family transcriptional repressor)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,004,908 - 16,072,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,004,473 - 16,072,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SPEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,004,908 - 16,072,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,004,473 - 16,072,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBIMhudiblu_PPA_v0panPan3
SPEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl115,836,095 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl115,847,707 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38115,847,707 - 15,940,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,174,359 - 16,266,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,046,946 - 16,139,537 (+)NCBINCBI36hg18NCBI36
Build 34115,919,664 - 16,012,256NCBI
Celera114,654,230 - 14,746,824 (+)NCBI
Cytogenetic Map1p36.21-p36.13NCBI
HuRef114,692,961 - 14,785,958 (+)NCBIHuRef
CHM1_1115,972,883 - 16,065,485 (+)NCBICHM1_1
Spen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIGRCm37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBImm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
Spen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
Spen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBIChiLan1.0ChiLan1.0
SPEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,683,824 - 81,775,904 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364743,473,892 - 3,535,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,015,521 - 75,107,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPEN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20116,361,008 - 116,458,064 (-)Ensembl
ChlSab1.120116,359,981 - 116,458,156 (-)NCBI
Spen
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,058,689 - 2,144,640 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000047944   ⟹   ENSPPAP00000025118
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl116,004,473 - 16,071,578 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047946   ⟹   ENSPPAP00000025120
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl116,004,908 - 16,072,585 (+)Ensembl
RefSeq Acc Id: XM_003806248   ⟹   XP_003806296
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1116,005,123 - 16,072,585 (+)NCBI
Mhudiblu_PPA_v0115,012,071 - 15,079,477 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034956134   ⟹   XP_034812025
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBI
RefSeq Acc Id: XM_034956140   ⟹   XP_034812031
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0114,987,416 - 15,079,477 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003806296 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812025 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812031 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003806296   ⟸   XM_003806248
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034812025   ⟸   XM_034956134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812031   ⟸   XM_034956140
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000025120   ⟸   ENSPPAT00000047946
RefSeq Acc Id: ENSPPAP00000025118   ⟸   ENSPPAT00000047944
Protein Domains
RRM   SPOC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035690 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000025118 UniProtKB/TrEMBL
  ENSPPAP00000025120 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047944 UniProtKB/TrEMBL
  ENSPPAT00000047946 UniProtKB/TrEMBL
Gene3D-CATH 2.40.290.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  SHARP_RRM1 UniProtKB/TrEMBL
  SHARP_RRM2 UniProtKB/TrEMBL
  SHARP_RRM3 UniProtKB/TrEMBL
  SHARP_RRM4 UniProtKB/TrEMBL
  SPOC-like_C_dom_sf UniProtKB/TrEMBL
  SPOC_C UniProtKB/TrEMBL
  SPOC_met UniProtKB/TrEMBL
NCBI Gene SPEN ENTREZGENE
Pfam RRM_1 UniProtKB/TrEMBL
  SPOC UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
  SPOC UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF100939 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A2R9B6A8_PANPA UniProtKB/TrEMBL
  A0A2R9BA05_PANPA UniProtKB/TrEMBL