NELFA (negative elongation factor complex member A) - Rat Genome Database

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Gene: NELFA (negative elongation factor complex member A) Pan paniscus
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Symbol: NELFA
Name: negative elongation factor complex member A
RGD ID: 11997584
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription elongation by RNA polymerase II (ortholog); positive regulation of protein modification process (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH cherubism (ortholog); FOUND IN cytosol (inferred); NELF complex (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC117979901; negative elongation factor A; uncharacterized LOC117979901; WHSC2; Wolf-Hirschhorn syndrome candidate 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,310,013 - 2,374,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,247,052 - 2,311,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,119,699 - 2,147,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,027,939 - 2,054,669 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,027,939 - 2,054,669 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
cherubism  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
NELF complex  (IEA)
nuclear body  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NELFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,310,013 - 2,374,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,247,052 - 2,311,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,119,699 - 2,147,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,027,939 - 2,054,669 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,027,939 - 2,054,669 (-)Ensemblpanpan1.1panPan2
NELFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,982,723 - 2,008,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,982,717 - 2,041,903 (-)EnsemblGRCh38hg38GRCh38
GRCh3741,984,450 - 2,010,701 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,954,248 - 1,980,547 (-)NCBINCBI36Build 36hg18NCBI36
Build 3441,951,683 - 1,977,980NCBI
Celera41,896,671 - 1,923,194 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,925,800 - 1,952,332 (-)NCBIHuRef
CHM1_141,983,104 - 2,009,627 (-)NCBICHM1_1
T2T-CHM13v2.041,981,232 - 2,007,492 (-)NCBIT2T-CHM13v2.0
Nelfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,055,263 - 34,093,615 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,055,260 - 34,093,757 (-)EnsemblGRCm39 Ensembl
GRCm38533,897,916 - 33,936,301 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,897,916 - 33,936,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37534,240,828 - 34,278,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,215,036 - 34,253,115 (-)NCBIMGSCv36mm8
Celera531,375,430 - 31,405,361 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Nelfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,033,470 - 81,057,546 (+)NCBIGRCr8
mRatBN7.21476,808,920 - 76,832,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,808,870 - 76,832,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,260,792 - 81,284,853 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,501,435 - 82,525,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,946,688 - 78,970,749 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,093,837 - 82,117,913 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,093,837 - 82,117,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,778,077 - 82,802,153 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,502,840 - 82,526,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,505,230 - 82,529,304 (+)NCBI
Celera1475,732,469 - 75,756,545 (+)NCBICelera
Cytogenetic Map14q21NCBI
Nelfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,162,993 - 1,173,278 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,162,993 - 1,173,278 (-)NCBIChiLan1.0ChiLan1.0
NELFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,147,948 - 62,164,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,147,948 - 62,164,112 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,665,674 - 64,682,273 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,623,281 - 62,639,884 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,623,336 - 62,639,877 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,115,860 - 62,133,779 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,319,512 - 62,337,145 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,679,577 - 62,696,178 (+)NCBIUU_Cfam_GSD_1.0
Nelfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,740,863 - 67,758,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,442,380 - 21,464,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,442,493 - 21,459,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,018,453 - 1,039,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,018,443 - 1,039,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28515,274 - 626,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,759,742 - 46,786,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,760,707 - 46,787,090 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,131,850 - 3,158,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nelfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,498,431 - 25,508,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,498,336 - 25,508,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000056290   ⟹   ENSPPAP00000033415
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl42,027,939 - 2,054,669 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056293   ⟹   ENSPPAP00000033418
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl42,035,086 - 2,054,194 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000056295   ⟹   ENSPPAP00000033420
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl42,052,336 - 2,054,194 (-)Ensembl
RefSeq Acc Id: XM_008965479   ⟹   XP_008963727
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,273,888 (-)NCBI
Mhudiblu_PPA_v042,119,699 - 2,146,405 (-)NCBI
PanPan1.142,027,939 - 2,054,669 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055111131   ⟹   XP_054967106
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,814 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,311,265 (-)NCBI
RefSeq Acc Id: XM_055111132   ⟹   XP_054967107
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,742 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,311,176 (-)NCBI
RefSeq Acc Id: XM_055111133   ⟹   XP_054967108
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,311,183 (-)NCBI
RefSeq Acc Id: XM_055111134   ⟹   XP_054967109
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,808 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,311,242 (-)NCBI
RefSeq Acc Id: XM_055111135   ⟹   XP_054967110
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,742 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,311,176 (-)NCBI
RefSeq Acc Id: XM_055111136   ⟹   XP_054967111
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
NHGRI_mPanPan142,247,052 - 2,311,183 (-)NCBI
RefSeq Acc Id: XM_063603668   ⟹   XP_063459738
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
RefSeq Acc Id: XM_063603669   ⟹   XP_063459739
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
RefSeq Acc Id: XM_063603670   ⟹   XP_063459740
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
RefSeq Acc Id: XM_063603671   ⟹   XP_063459741
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v232,310,013 - 2,374,749 (-)NCBI
RefSeq Acc Id: XP_008963727   ⟸   XM_008965479
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSPPAP00000033420   ⟸   ENSPPAT00000056295
Ensembl Acc Id: ENSPPAP00000033415   ⟸   ENSPPAT00000056290
Ensembl Acc Id: ENSPPAP00000033418   ⟸   ENSPPAT00000056293
RefSeq Acc Id: XP_054967106   ⟸   XM_055111131
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054967109   ⟸   XM_055111134
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054967108   ⟸   XM_055111133
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054967111   ⟸   XM_055111136
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054967110   ⟸   XM_055111135
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054967107   ⟸   XM_055111132
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063459741   ⟸   XM_063603671
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BY58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459739   ⟸   XM_063603669
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063459740   ⟸   XM_063603670
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BY58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459738   ⟸   XM_063603668
- Peptide Label: isoform X1
Protein Domains
HDAg


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056290.1 UniProtKB/TrEMBL
  ENSPPAT00000056293.1 UniProtKB/TrEMBL
  ENSPPAT00000056295.1 UniProtKB/TrEMBL
InterPro HDAG_dom UniProtKB/TrEMBL
  NELF-A_domain UniProtKB/TrEMBL
NCBI Gene NELFA ENTREZGENE
PANTHER NEGATIVE ELONGATION FACTOR A UniProtKB/TrEMBL
  NEGATIVE ELONGATION FACTOR A NELF-A UniProtKB/TrEMBL
PROSITE HDAG UniProtKB/TrEMBL
UniProt A0A2R9BUR6_PANPA UniProtKB/TrEMBL
  A0A2R9BY58 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BY63_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-20 NELFA  negative elongation factor complex member A  LOC117979901  uncharacterized LOC117979901  Data merged from RGD:32727465 737654 PROVISIONAL