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Gene: BMP5 (bone morphogenetic protein 5) Pan paniscus

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Symbol:

BMP5

Name:

bone morphogenetic protein 5

RGD ID:

11994484

Description:

ENCODES a protein that exhibits BMP receptor binding (inferred); cytokine activity (inferred); growth factor activity (inferred); INVOLVED IN allantois development (ortholog); anterior head development (ortholog); cardiac muscle tissue development (ortholog); ASSOCIATED WITH Congenital Microtia (ortholog); Meier-Gorlin syndrome (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	70,217,543 - 70,341,856 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	66,094,284 - 66,218,613 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	55,302,721 - 55,425,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	56,936,871 - 57,058,801 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	56,936,850 - 57,059,519 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Congenital Microtia (ISO)

Meier-Gorlin syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

allantois development (ISO)

anterior head development (ISO)

BMP signaling pathway (IEA)

cardiac muscle tissue development (ISO)

cardiac septum morphogenesis (ISO)

chorio-allantoic fusion (ISO)

ear development (ISO)

endocardial cushion formation (ISO)

heart trabecula morphogenesis (ISO)

hindbrain development (ISO)

male genitalia development (ISO)

negative regulation of aldosterone biosynthetic process (IEA)

negative regulation of cell population proliferation (IEA)

negative regulation of cortisol biosynthetic process (IEA)

negative regulation of insulin-like growth factor receptor signaling pathway (IEA)

negative regulation of steroid biosynthetic process (IEA)

neural fold elevation formation (ISO)

pattern specification process (ISO)

pericardium morphogenesis (ISO)

pharyngeal system development (ISO)

positive regulation of cell population proliferation (IEA)

positive regulation of dendrite development (IEA)

positive regulation of epithelial cell proliferation (IEA)

positive regulation of SMAD protein signal transduction (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

skeletal system development (ISO)

type B pancreatic cell development (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA,ISO)

vesicle (ISO)

Molecular Function

BMP receptor binding (IEA)

cytokine activity (IEA)

growth factor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BMP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	70,217,543 - 70,341,856 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	66,094,284 - 66,218,613 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	55,302,721 - 55,425,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	56,936,871 - 57,058,801 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	56,936,850 - 57,059,519 (-)	Ensembl	panpan1.1		panPan2

BMP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	55,753,653 - 55,875,590 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	55,753,653 - 55,875,590 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	55,618,451 - 55,740,388 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	55,728,195 - 55,848,334 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	55,728,198 - 55,848,334	NCBI
Celera	6	57,281,444 - 57,401,579 (-)	NCBI		Celera
Cytogenetic Map	6	p12.1	NCBI
HuRef	6	55,455,271 - 55,575,481 (-)	NCBI		HuRef
CHM1_1	6	55,623,337 - 55,743,453 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	55,593,278 - 55,715,204 (-)	NCBI		T2T-CHM13v2.0

Bmp5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	75,682,647 - 75,807,598 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	75,682,646 - 75,807,592 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	75,775,365 - 75,900,316 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	75,775,364 - 75,900,310 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	75,623,172 - 75,746,824 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	75,561,274 - 75,684,926 (+)	NCBI		MGSCv36	mm8
Celera	9	72,947,674 - 73,071,783 (+)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	42.34	NCBI

Bmp5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	85,397,629 - 85,520,374 (+)	NCBI		GRCr8
mRatBN7.2	8	76,517,164 - 76,639,925 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	76,517,164 - 76,639,925 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	82,030,944 - 82,153,707 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	80,289,767 - 80,412,506 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	78,130,272 - 78,253,044 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	82,669,466 - 82,950,273 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	82,878,941 - 82,950,273 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	82,266,949 - 82,526,447 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	80,593,053 - 80,717,015 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	80,610,468 - 80,733,833 (+)	NCBI
Celera	8	76,306,530 - 76,429,126 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Bmp5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	450,674 - 558,650 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	450,674 - 557,213 (+)	NCBI	ChiLan1.0	ChiLan1.0

BMP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	23,089,429 - 23,202,176 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	23,089,459 - 23,202,348 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	22,980,188 - 23,092,541 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	23,587,541 - 23,700,170 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	23,587,187 - 23,699,514 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	23,083,296 - 23,195,652 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	23,187,441 - 23,299,694 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	23,319,382 - 23,432,016 (-)	NCBI		UU_Cfam_GSD_1.0

Bmp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	58,495,816 - 58,609,333 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	5,350,870 - 5,464,354 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	5,350,870 - 5,464,561 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BMP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	25,344,822 - 25,470,470 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	25,344,924 - 25,468,430 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	29,657,701 - 29,658,702 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	7	29,873,198 - 29,939,042 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BMP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	15,696,379 - 15,819,454 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	15,696,580 - 15,819,564 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	21,842,528 - 21,973,085 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bmp5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624850	3,322,782 - 3,481,512 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624850	3,324,553 - 3,481,439 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003828929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000005757 ⟹ ENSPPAP00000001212

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	56,936,850 - 57,059,519 (-)	Ensembl

RefSeq Acc Id:

XM_003828929 ⟹ XP_003828977

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	70,217,543 - 70,341,856 (-)	NCBI
NHGRI_mPanPan1	6	66,094,284 - 66,218,613 (-)	NCBI
Mhudiblu_PPA_v0	6	55,302,721 - 55,425,248 (-)	NCBI
PanPan1.1	6	56,936,871 - 57,058,801 (-)	NCBI

Sequence:

show sequence

GGACAAAAATGCATCTGACTGTATTTTTACTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTG
GGTTCTAGTGGGTTATGCAAAAGGAGGTTTGGGAGACAATCATGTTCACTCCAGTTTTATTTAT
AGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTCTCTCTATCTTGGGTTTGC
CTCACAGACCCAGACCATTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGA
TCTCTACAATGCCATGACCAATGAAGAAAATCCTGAAGAGTCGGAGTACTCAGTAAGGGCATCC
TTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGATACCCAGCCTCTCCCAATGGGTATCCTCGTC
GCATACAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCCATGA
TACCAACTTTCTGAATGATGCTGACATGGTCATGAGCTTTGTCAACTTAGTTGAAAGAGACAAG
GATTTTTCTCACCAGCGAAGGCATTACAAAGAATTTCGATTTGATCTTACCCAAATTCCTCATG
GAGAGGCAGTGACAGCAGCTGAATTCCGGATATACAAGGACCGGAGCAACAACCGATTTGAAAA
TGAAACAATTAAGATTAGCATATATCAAATCATCAAGGAATACACAAATAGGGATGCAGATCTG
TTCTTGTTAGACACAAGAAAGGCCCAAGCTTTAGATGTGGGTTGGCTTGTCTTTGATATCACTG
TGACCAGCAATCATTGGGTGATTAATCCCCAGAATAATTTGGGCTTACAGCTCTGTGCAGAAAC
AGGGGATGGACGCAGTATCAACGTAAAATCTGCTGGTCTCGTGGGAAGACAGGGACCTCAGTCA
AAACAACCATTCATGGTGGCCTTCTTCAAGGCGAGTGAGGTACTTCTTCGATCCGTGAGAGCAG
CCAACAAACGAAAAAATCAAAACCGCAATAAATCCACCTCTCATCAGGACTCCTCCAGAATGTC
CAGTGTTGGAGATTATAACACAAGTGAGCAAAAACAAGCCTGTAAGAAGCACGAACTCTATGTG
AGCTTCCGGGATCTGGGATGGCAGGACTGGATTATAGCACCAGAAGGATATGCTGCATTTTATT
GTGATGGAGAATGTTCTTTTCCACTTAACGCCCATATGAATGCCACCAACCACGCTATAGTTCA
GACTCTGGTTCATCTGATGTTTCCTGACCACGTACCAAAGCCTTGTTGTGCTCCAACCAAATTA
AATGCCATCTCTGTTCTGTACTTTGATGACAGCTCCAATGTCATTTTGAAAAAATATAGAAATA
TGGTAGTACGCTCATGTGGCTGCCACTAATATTAAATAATATTGATAATAACAAAAAGATCTGT
ATTAAGGTTTATGGCTGCAATAAAAAGCATACTTTCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003828977	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000001212.1

RefSeq Acc Id:

XP_003828977 ⟸ XM_003828929

- UniProtKB:

A0A2R8Z8H0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHR
PRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASPNGYPRRIQ
LSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEA
VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTS
NHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANK
RKNQNRNKSTSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDG
ECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVV
RSCGCH

hide sequence

Ensembl Acc Id:

ENSPPAP00000001212 ⟸ ENSPPAT00000005757

Protein Domains

TGF-beta family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000005216	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000005757.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_propeptide	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	pps:100989910	UniProtKB/TrEMBL
NCBI Gene	BMP5	ENTREZGENE
PANTHER	BONE MORPHOGENETIC PROTEIN 5	UniProtKB/TrEMBL
	PTHR11848	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A2R8Z8H0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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