GALE (UDP-galactose-4-epimerase) - Rat Genome Database

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Pathways
Gene: GALE (UDP-galactose-4-epimerase) Pan paniscus
Analyze
Symbol: GALE
Name: UDP-galactose-4-epimerase
RGD ID: 11987737
Description: ENCODES a protein that exhibits identical protein binding (inferred); isomerase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN galactose catabolic process (inferred); galactose catabolic process via UDP-galactose, Leloir pathway (inferred); galactose metabolic process (inferred); PARTICIPATES IN galactokinase deficiency pathway; galactose metabolic pathway; galactosemia pathway; ASSOCIATED WITH galactose epimerase deficiency (ortholog); galactosemia (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: UDP-glucose 4-epimerase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,140,293 - 203,145,510 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,243,277 - 202,248,475 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,987,218 - 22,992,416 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,971,454 - 23,976,648 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,971,454 - 23,976,500 (-)EnsemblpanPan2panpan1.1
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GALE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,140,293 - 203,145,510 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,243,277 - 202,248,475 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,987,218 - 22,992,416 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,971,454 - 23,976,648 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,971,454 - 23,976,500 (-)EnsemblpanPan2panpan1.1
GALE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,795,599 - 23,800,754 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,795,599 - 23,800,781 (-)Ensemblhg38GRCh38
GRCh37124,122,089 - 24,127,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,994,676 - 23,999,881 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34123,867,394 - 23,872,600NCBI
Celera122,451,653 - 22,456,862 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef122,373,666 - 22,378,871 (-)NCBIHuRef
CHM1_1124,234,878 - 24,240,083 (-)NCBICHM1_1
T2T-CHM13v2.0123,630,574 - 23,635,729 (-)NCBIT2T-CHM13v2.0
Gale
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,690,550 - 135,695,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,691,038 - 135,695,489 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384135,963,681 - 135,968,178 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,963,727 - 135,968,178 (+)Ensemblmm10GRCm38
MGSCv374135,521,080 - 135,524,093 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364135,237,241 - 135,240,254 (+)NCBIMGSCv36mm8
Celera4134,166,296 - 134,169,303 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.29NCBI
Gale
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,477,420 - 153,481,926 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,478,325 - 153,481,922 (+)EnsemblGRCr8
mRatBN7.25148,193,886 - 148,198,392 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,194,791 - 148,198,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,892,892 - 150,897,395 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,667,161 - 152,671,664 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,649,173 - 152,653,676 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,310,453 - 154,314,959 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,310,453 - 154,314,955 (+)Ensemblrn6Rnor6.0
Rnor_5.05158,075,304 - 158,079,822 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,745,853 - 154,750,357 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,600,743 - 146,605,247 (+)NCBICelera
RGSC_v3.15154,757,427 - 154,760,391 (+)NCBI
Cytogenetic Map5q36NCBI
Gale
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,713,080 - 3,718,425 (-)Ensembl
ChiLan1.0NW_0049554523,715,107 - 3,719,288 (-)NCBIChiLan1.0ChiLan1.0
GALE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,704,012 - 75,708,206 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,704,558 - 75,708,169 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha272,273,414 - 72,278,306 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0276,262,612 - 76,267,504 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,263,323 - 76,267,499 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,084,965 - 73,089,857 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,091,618 - 74,096,497 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,097,212 - 75,102,105 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gale
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,125,032 - 43,129,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,949,798 - 8,954,315 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,949,814 - 8,954,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GALE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,605,968 - 81,610,473 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1681,605,968 - 81,610,535 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,416,319 - 75,420,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GALE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,883,796 - 108,889,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20108,886,161 - 108,892,562 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660337,445,136 - 7,450,240 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gale
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,344,179 - 8,348,393 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247648,344,180 - 8,348,549 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gale
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1122,261,586 - 22,264,847 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000014436   ⟹   ENSPPAP00000003131
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl123,971,454 - 23,976,500 (-)Ensembl
RefSeq Acc Id: XM_008963121   ⟹   XP_008961369
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21203,140,293 - 203,145,510 (+)NCBI
NHGRI_mPanPan11202,243,277 - 202,248,475 (+)NCBI
Mhudiblu_PPA_v0122,987,218 - 22,992,416 (-)NCBI
PanPan1.1123,971,454 - 23,976,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963122   ⟹   XP_008961370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21203,140,414 - 203,145,510 (+)NCBI
NHGRI_mPanPan11202,243,409 - 202,248,475 (+)NCBI
Mhudiblu_PPA_v0122,987,218 - 22,992,271 (-)NCBI
PanPan1.1123,971,454 - 23,976,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963125   ⟹   XP_008961373
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21203,140,303 - 203,145,510 (+)NCBI
NHGRI_mPanPan11202,243,277 - 202,248,475 (+)NCBI
Mhudiblu_PPA_v0122,987,218 - 22,992,416 (-)NCBI
PanPan1.1123,971,454 - 23,976,642 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963126   ⟹   XP_008961374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21203,140,312 - 203,145,510 (+)NCBI
NHGRI_mPanPan11202,243,277 - 202,248,475 (+)NCBI
Mhudiblu_PPA_v0122,987,218 - 22,992,416 (-)NCBI
PanPan1.1123,971,454 - 23,976,642 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055096540   ⟹   XP_054952515
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21203,140,414 - 203,145,510 (+)NCBI
NHGRI_mPanPan11202,243,380 - 202,248,475 (+)NCBI
RefSeq Acc Id: XP_008961369   ⟸   XM_008963121
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZDL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008961374   ⟸   XM_008963126
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008961373   ⟸   XM_008963125
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008961370   ⟸   XM_008963122
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZDL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000003131   ⟸   ENSPPAT00000014436
RefSeq Acc Id: XP_054952515   ⟸   XM_055096540
- Peptide Label: isoform X2
Protein Domains
NAD(P)-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000013178 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050028281 ENTREZGENE
Ensembl Transcript ENSPPAT00000014436.1 UniProtKB/TrEMBL
  ENSPPAT00050060475 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  UDP-galactose 4-epimerase, domain 1 UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  UDP_G4E UniProtKB/TrEMBL
KEGG Report pps:100986058 UniProtKB/TrEMBL
NCBI Gene GALE ENTREZGENE
PANTHER UDP-GLUCOSE 4-EPIMERASE UniProtKB/TrEMBL
  UDP-GLUCOSE 4-EPIMERASE UniProtKB/TrEMBL
Pfam GDP_Man_Dehyd UniProtKB/TrEMBL
PRINTS NUCEPIMERASE UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A2R8ZDL9 ENTREZGENE, UniProtKB/TrEMBL