ADAM21 (ADAM metallopeptidase domain 21) - Rat Genome Database

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Gene: ADAM21 (ADAM metallopeptidase domain 21) Pan paniscus
Analyze
Symbol: ADAM21
Name: ADAM metallopeptidase domain 21
RGD ID: 11963860
Description: ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN male gonad development (inferred); proteolysis (inferred); FOUND IN axon (ortholog); neuron projection (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 21; LOC100969567
RGD Orthologs
Human
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,913,385 - 69,921,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,913,385 - 69,921,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensemblpanpan1.1panPan2
ADAM21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381470,452,174 - 70,459,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1470,417,107 - 70,460,427 (+)EnsemblGRCh38hg38GRCh38
GRCh371470,918,891 - 70,926,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,993,970 - 69,996,375 (+)NCBINCBI36Build 36hg18NCBI36
Build 341469,993,969 - 69,996,375NCBI
Celera1450,988,177 - 50,990,582 (+)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1451,087,543 - 51,095,293 (+)NCBIHuRef
CHM1_11470,856,830 - 70,864,579 (+)NCBICHM1_1
T2T-CHM13v2.01464,658,196 - 64,665,929 (+)NCBIT2T-CHM13v2.0
Adam21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,605,349 - 81,615,248 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,605,358 - 81,615,248 (-)EnsemblGRCm39 Ensembl
GRCm381281,558,575 - 81,568,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,558,584 - 81,568,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,659,571 - 82,669,461 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,477,432 - 82,487,322 (-)NCBIMGSCv36mm8
Celera1283,025,745 - 83,035,635 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.79NCBI
Adam21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,351,935 - 43,361,020 (+)NCBIGRCr8
mRatBN7.21636,625,324 - 36,627,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,618,860 - 36,628,008 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01639,138,561 - 39,148,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01638,925,310 - 38,934,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1634,773,480 - 34,783,278 (+)NCBICelera
Cytogenetic Map16p11NCBI
ADAM21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1844,238,624 - 44,269,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl844,238,864 - 44,241,023 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,903,984 - 43,934,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0844,463,005 - 44,493,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl844,463,245 - 44,465,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1844,115,179 - 44,145,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0844,161,974 - 44,192,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0844,522,701 - 44,553,570 (-)NCBIUU_Cfam_GSD_1.0
LOC100515389
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1794,084,019 - 94,087,956 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27100,372,847 - 100,392,821 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000035498   ⟹   ENSPPAP00000012831
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensembl
RefSeq Acc Id: XM_034937733   ⟹   XP_034793624
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBI
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBI
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBI
RefSeq Acc Id: XM_055097743   ⟹   XP_054953718
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21571,573,689 - 71,581,469 (+)NCBI
NHGRI_mPanPan11470,789,774 - 70,797,982 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034793624 (Get FASTA)   NCBI Sequence Viewer  
  XP_054953718 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012831.1
RefSeq Acc Id: XP_034793624   ⟸   XM_034937733
- UniProtKB: A0A2R9AB15 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000012831   ⟸   ENSPPAT00000035498
RefSeq Acc Id: XP_054953718   ⟸   XM_055097743
Protein Domains
Disintegrin   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029592 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035498.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene ADAM21 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A2R9AB15 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 ADAM21  ADAM metallopeptidase domain 21  LOC100969567  disintegrin and metalloproteinase domain-containing protein 21  Symbol and/or name change 5135510 APPROVED
2020-07-01 LOC100969567  disintegrin and metalloproteinase domain-containing protein 21  ADAM21  ADAM metallopeptidase domain 21  Symbol and/or name change 5135510 APPROVED