ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3) - Rat Genome Database

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Gene: ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3) Pan paniscus
Analyze
Symbol: ADAMTS3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
RGD ID: 11960468
Description: ENCODES a protein that exhibits endopeptidase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN in utero embryonic development (ortholog); protein processing (ortholog); ASSOCIATED WITH genetic disease (ortholog); Hennekam Lymphangiectasia-Lymphedema Syndrome 3 (ortholog); prostate cancer (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2357,511,238 - 57,801,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1457,705,360 - 57,998,579 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0451,648,293 - 51,941,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1457,965,585 - 58,258,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl457,966,197 - 58,259,404 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAMTS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2357,511,238 - 57,801,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1457,705,360 - 57,998,579 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0451,648,293 - 51,941,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1457,965,585 - 58,258,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl457,966,197 - 58,259,404 (+)Ensemblpanpan1.1panPan2
ADAMTS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38472,280,969 - 72,569,221 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl472,280,969 - 72,569,221 (-)EnsemblGRCh38hg38GRCh38
GRCh37473,146,686 - 73,434,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36473,365,551 - 73,653,380 (-)NCBINCBI36Build 36hg18NCBI36
Build 34473,511,721 - 73,799,551NCBI
Celera470,502,659 - 70,790,668 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef468,951,493 - 69,241,512 (-)NCBIHuRef
CHM1_1473,182,184 - 73,470,272 (-)NCBICHM1_1
T2T-CHM13v2.0475,623,227 - 75,912,559 (-)NCBIT2T-CHM13v2.0
Adamts3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,821,700 - 90,031,521 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,824,946 - 90,031,193 (-)EnsemblGRCm39 Ensembl
GRCm38589,673,841 - 89,883,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,677,087 - 89,883,334 (-)EnsemblGRCm38mm10GRCm38
MGSCv37590,102,866 - 90,312,359 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,752,120 - 90,958,605 (-)NCBIMGSCv36mm8
Celera587,807,909 - 88,027,173 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
Adamts3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81418,515,249 - 18,721,887 (+)NCBIGRCr8
mRatBN7.21418,231,128 - 18,437,771 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,231,165 - 18,435,556 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,223,355 - 18,428,156 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,542,250 - 19,747,040 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01418,250,519 - 18,460,965 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,866,278 - 20,072,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,866,408 - 20,070,994 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,772,990 - 19,979,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,756,887 - 19,963,451 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11419,692,864 - 19,963,098 (+)NCBI
Celera1417,597,010 - 17,800,450 (+)NCBICelera
Cytogenetic Map14p22NCBI
Adamts3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955447803,057 - 1,036,485 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955447803,287 - 1,036,435 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11361,278,193 - 61,539,545 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1360,948,190 - 61,207,761 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01362,087,170 - 62,348,334 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1362,087,170 - 62,348,750 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11361,697,369 - 61,958,167 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01361,186,735 - 61,446,690 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01362,338,060 - 62,599,375 (-)NCBIUU_Cfam_GSD_1.0
Adamts3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528514,228,612 - 14,449,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365982,680,087 - 2,901,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365982,680,623 - 2,901,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl868,675,070 - 68,948,414 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1868,675,067 - 68,948,537 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2872,588,988 - 72,885,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1720,793,392 - 21,068,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl720,793,399 - 21,048,515 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660841,744,928 - 2,020,967 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248903,738,186 - 3,925,491 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248903,738,727 - 3,925,377 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000058769   ⟹   ENSPPAP00000035880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl457,966,197 - 58,259,404 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000058776   ⟹   ENSPPAP00000035887
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl457,966,450 - 58,259,404 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000058785   ⟹   ENSPPAP00000035896
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl458,198,561 - 58,227,982 (+)Ensembl
RefSeq Acc Id: XM_003818364   ⟹   XP_003818412
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2357,511,238 - 57,801,709 (+)NCBI
NHGRI_mPanPan1457,705,360 - 57,998,579 (+)NCBI
Mhudiblu_PPA_v0451,648,293 - 51,941,329 (+)NCBI
PanPan1.1457,965,585 - 58,258,295 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818412 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000035880
  ENSPPAP00000035880.1
  ENSPPAP00000035887.1
  ENSPPAP00000035896.1
RefSeq Acc Id: XP_003818412   ⟸   XM_003818364
- UniProtKB: A0A2R9CC15 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000035880   ⟸   ENSPPAT00000058769
Ensembl Acc Id: ENSPPAP00000035887   ⟸   ENSPPAT00000058776
Ensembl Acc Id: ENSPPAP00000035896   ⟸   ENSPPAT00000058785
Protein Domains
Peptidase M12B   PLAC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058769.1 UniProtKB/TrEMBL
  ENSPPAT00000058776.1 UniProtKB/TrEMBL
  ENSPPAT00000058785.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report pps:100994048 UniProtKB/TrEMBL
NCBI Gene ADAMTS3 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 3 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
  TSP1REPEAT UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A2R9C2C1_PANPA UniProtKB/TrEMBL
  A0A2R9C4T6_PANPA UniProtKB/TrEMBL
  A0A2R9CC15 ENTREZGENE, UniProtKB/TrEMBL