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Gene: PAIP2 (poly(A) binding protein interacting protein 2) Pan paniscus

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Symbol:

PAIP2

Name:

poly(A) binding protein interacting protein 2

RGD ID:

11944558

Description:

ENCODES a protein that exhibits mRNA binding (inferred); mRNA regulatory element binding translation repressor activity (inferred); translation repressor activity (inferred); INVOLVED IN memory (ortholog); negative regulation of translation (ortholog); regulation of long-term synaptic potentiation (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 31 (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis 1 (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

polyadenylate-binding protein-interacting protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	134,608,493 - 134,636,576 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	132,748,046 - 132,776,128 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	134,712,834 - 134,740,747 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	140,835,320 - 140,862,743 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	140,835,320 - 140,862,743 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

Colorectal Neoplasms (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

STING-associated vasculopathy with onset in infancy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

memory (IEA,ISO)

negative regulation of translation (IEA,ISO)

negative regulation of translational initiation (IEA)

regulation of long-term synaptic potentiation (IEA,ISO)

regulation of translation (IEA,ISO)

spermatogenesis (IEA,ISO)

translation (IEA,ISO)

Cellular Component

cytoplasm (IEA)

Molecular Function

mRNA binding (IEA)

mRNA regulatory element binding translation repressor activity (IEA)

protein binding (ISO)

translation repressor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

PAIP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	134,608,493 - 134,636,576 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	132,748,046 - 132,776,128 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	134,712,834 - 134,740,747 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	140,835,320 - 140,862,743 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	140,835,320 - 140,862,743 (+)	Ensembl	panpan1.1		panPan2

PAIP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	139,341,854 - 139,369,717 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	139,341,587 - 139,369,720 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	138,677,543 - 138,705,406 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	138,705,418 - 138,733,308 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	138,705,449 - 138,733,305	NCBI
Celera	5	134,799,217 - 134,827,120 (+)	NCBI		Celera
Cytogenetic Map	5	q31.2	NCBI
HuRef	5	133,867,084 - 133,895,145 (+)	NCBI		HuRef
CHM1_1	5	138,110,119 - 138,138,025 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	139,867,910 - 139,895,795 (+)	NCBI		T2T-CHM13v2.0

Paip2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	35,731,649 - 35,750,239 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	35,731,670 - 35,750,240 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	35,598,610 - 35,617,186 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	35,598,617 - 35,617,187 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	35,758,321 - 35,776,839 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	35,724,641 - 35,743,159 (+)	NCBI		MGSCv36	mm8
Celera	18	36,054,656 - 36,073,337 (+)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.16	NCBI

Paip2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	27,475,278 - 27,492,452 (+)	NCBI		GRCr8
mRatBN7.2	18	27,199,762 - 27,218,359 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	27,199,796 - 27,214,863 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	1	179,077,601 - 179,077,975 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	27,328,608 - 27,345,782 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	28,090,702 - 28,107,928 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	27,425,587 - 27,442,814 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	28,397,320 - 28,415,911 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	28,409,955 - 28,415,910 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	28,111,847 - 28,129,021 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	28,223,680 - 28,240,856 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	28,250,325 - 28,267,501 (+)	NCBI
Celera	18	26,934,764 - 26,951,907 (+)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

Paip2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	1,189,822 - 1,208,559 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	1,189,822 - 1,208,559 (-)	NCBI	ChiLan1.0	ChiLan1.0

PAIP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	34,671,130 - 34,695,974 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	34,671,150 - 34,695,299 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	31,773,440 - 31,798,270 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	35,125,205 - 35,150,041 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	35,125,241 - 35,150,039 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	32,177,630 - 32,202,503 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	33,043,986 - 33,068,801 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	33,795,586 - 33,820,421 (+)	NCBI		UU_Cfam_GSD_1.0

Paip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	153,157,525 - 153,179,576 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	8,431,798 - 8,456,498 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	8,431,950 - 8,453,980 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAIP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	141,237,438 - 141,261,125 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	141,237,417 - 141,260,207 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	147,068,026 - 147,090,813 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PAIP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	42,002,525 - 42,042,056 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	42,002,482 - 42,042,777 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	35,845,934 - 35,887,870 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Paip2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624743	32,152,007 - 32,171,111 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003829215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000056630 ⟹ ENSPPAP00000033753

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	140,835,320 - 140,862,743 (+)	Ensembl

RefSeq Acc Id:

XM_003829215 ⟹ XP_003829263

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	134,608,493 - 134,636,576 (+)	NCBI
NHGRI_mPanPan1	5	132,748,046 - 132,776,128 (+)	NCBI
Mhudiblu_PPA_v0	5	134,712,834 - 134,740,747 (+)	NCBI
PanPan1.1	5	140,835,320 - 140,862,743 (+)	NCBI

Sequence:

show sequence

CACTTCCGGGCTGGGGTGTTTGTTTGGACTGGAGAAGGGAGGCGGCGGGCGAAGCGCACGTCGA
GCGGGGGAGCGGCGCTGCCTGTGGAGATCCGCGGAGGCCGACAGGATTCGTTGGCTGCCGTCCC
CGCTGCTGTGCATTGGGTTAAAAACGACAACCAACATCAGCCATGAAAGATCCAAGTCGCAGCA
GTACTAGCCCAAGCATCATCAATGAAGATGTGATTATTAACGGTCATTCTCATGAAGATGACAA
TCCATTTGCAGAGTACATGTGGATGGAAAATGAAGAAGAATTCAACAGACAAATAGAAGAGGAG
TTATGGGAAGAAGAATTTATTGAACGCTGTTTCCAAGAAATGCTGGAAGAGGAAGAAGAGCATG
AATGGTTTATTCCAGCTCGAGATCTCCCACAAACTATGGACCAAATCCAAGACCAGTTTAATGA
CCTTGTTATCAGTGATGGCTCTTCTCTGGAAGATCTTGTGGTCAAGAGCAATCTGAATCCAAAT
GCAAAGGAGTTTGTTCCTGGGGTGAAGTACTGAAATATTTGAGTAGACGGGGCCCTCTTTTGGT
GGATGTAGCACAATTTCCACACTGTGAAGGCAGTATTAGAAGACTTAATTGTAAAAGCTCTCTC
GTCACTGTGTTACACTTATGCATTGCCAAAGTTTTTGTTAGTCTTGCATGCTTAATAAAAGTGC
TGAGACTGTTACTAAGTAAAAAGCTGTCAAACATTTACTGAAAATAGAATTGGCCCCATGGCTT
GATGTGAAGACAGCAAGGAAAGAAGCACCAGTCAAGTTGTGAACAAGCACCAAATTAAAAGACC
TAAACCTTACCAAATTGTCTTTTTTTGAGGCTAATCTATCACTTGCTAATGTCTAAACTTTAAA
ATCAGTACATTTAATTTGAGTTCCAACTGTTAAGCATATTTCTCAGACTTAAATTTGATTATGT
CCCCATCAAAAAGAATCTCCATTTTCTGAAGGTCTGTTAGTTAATTTGAGATAATTTGTTAAAG
GCAAGTATGTCATATTACTGAGGCTACAAGTTAGTCAGCAGATGAGTGCCAGTCCAGCCTTTTC
TGGTATGTTATTGTTAGAAATATTGAGTTCTAATGTTACATCTGAGGAAGTATGTAATTTGAGA
ATTGTAACTTCTAAGGGATTCACTGCATCATAGCTATGCCTGTATGGAGTCTAACATATGACCA
ATACCAACCCATAATCCAGCTGAACAAAGATACTGTAACATTATGATTTGAGTGGTGCTTTTCC
TTGCTTTGTTAACCATCACGAGAGTCTGCAGCACAACTTTTCTTTTAACAAAGCTAGAACAGTT
TTGGCTTCTTAAACTTCATATTTGGGTAGGTTAAGCTGCCATACGTGTTCAGTGTGAATAGTGT
TTAAGTTGAAAATATTGTAAAAAAATTATATTTTTTCAAAAATATTTAAAAAAATAAATAATAG
TAGAACTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003829263	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000033753
	ENSPPAP00000033753.1

RefSeq Acc Id:	XP_003829263 ⟸ XM_003829215
- UniProtKB:	A0A2R9BVP9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEM LEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKY hide sequence

Ensembl Acc Id:

ENSPPAP00000033753 ⟸ ENSPPAT00000056630

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039741	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000056630.1	UniProtKB/TrEMBL
InterPro	Ataxin-2_C	UniProtKB/TrEMBL
	PAIP2-like	UniProtKB/TrEMBL
KEGG Report	pps:100986520	UniProtKB/TrEMBL
NCBI Gene	PAIP2	ENTREZGENE
PANTHER	POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2	UniProtKB/TrEMBL
	PTHR13154	UniProtKB/TrEMBL
Pfam	PAM2	UniProtKB/TrEMBL
UniProt	A0A2R9BVP9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD