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Gene: PDE10A (phosphodiesterase 10A) Pan paniscus

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Symbol:

PDE10A

Name:

phosphodiesterase 10A

RGD ID:

11938393

Description:

ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); cAMP binding (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN cAMP catabolic process (ortholog); cGMP catabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); Infantile-Onset Limb and Orofacial Dyskinesia (ortholog); FOUND IN cytosol (ortholog); extrinsic component of postsynaptic density membrane (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE10A (phosphodiesterase 10A)	NCBI	Ortholog
Mus musculus (house mouse):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDE10A (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pde10a (phosphodiesterase 10A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	185,514,841 - 186,181,000 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	183,411,044 - 184,076,963 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	163,274,252 - 163,612,749 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	168,259,978 - 168,596,401 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	168,265,707 - 168,645,231 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disabilities (ISO)

genetic disease (ISO)

Infantile-Onset Limb and Orofacial Dyskinesia (ISO)

Muscle Hypotonia (ISO)

striatal degeneration 2 (ISO)

traumatic brain injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cAMP catabolic process (ISO)

cGMP catabolic process (ISO)

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

regulation of cAMP/PKA signal transduction (IEA)

signal transduction (IEA)

Cellular Component

cytosol (ISO)

extrinsic component of postsynaptic density membrane (ISO)

glutamatergic synapse (IEA)

neuronal cell body (ISO)

perikaryon (ISO)

synapse (IEA)

Molecular Function

3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ISO)

3',5'-cyclic-nucleotide phosphodiesterase activity (IEA)

cAMP binding (ISO)

cyclic-nucleotide phosphodiesterase activity (ISO)

hydrolase activity (IEA)

metal ion binding (IEA)

phosphoric diester hydrolase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

protein kinase A (PKA) signaling pathway (ISO)

purine metabolic pathway (ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PDE10A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	185,514,841 - 186,181,000 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	183,411,044 - 184,076,963 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	163,274,252 - 163,612,749 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	168,259,978 - 168,596,401 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	168,265,707 - 168,645,231 (-)	Ensembl	panpan1.1		panPan2

PDE10A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	165,327,289 - 165,988,052 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	165,327,287 - 165,988,117 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	165,740,778 - 166,076,729 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	165,664,519 - 165,995,574 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	165,714,945 - 166,045,996	NCBI
Celera	6	166,478,886 - 166,814,271 (-)	NCBI		Celera
Cytogenetic Map	6	q27	NCBI
HuRef	6	163,202,267 - 163,537,621 (-)	NCBI		HuRef
CHM1_1	6	166,003,719 - 166,338,432 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	166,693,362 - 167,356,384 (-)	NCBI		T2T-CHM13v2.0

Pde10a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	8,742,719 - 9,205,480 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	8,744,204 - 9,205,480 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	8,525,187 - 8,986,648 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	8,525,372 - 8,986,648 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	8,994,610 - 9,179,513 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	8,639,919 - 8,824,822 (+)	NCBI		MGSCv36	mm8
Celera	17	8,848,994 - 9,030,858 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	4.96	NCBI

Pde10a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	54,313,343 - 54,765,668 (-)	NCBI		GRCr8
mRatBN7.2	1	51,765,743 - 52,218,086 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	51,770,132 - 52,216,563 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	52,476,016 - 52,919,928 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	58,463,473 - 58,911,420 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	52,551,592 - 52,995,519 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	52,360,296 - 52,544,448 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	52,360,296 - 52,544,450 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	53,617,430 - 53,800,479 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	46,392,900 - 46,589,076 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	46,395,844 - 46,592,020 (-)	NCBI
Celera	1	47,539,418 - 47,723,290 (-)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

Pde10a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	16,114,530 - 16,365,146 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	16,114,530 - 16,370,648 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDE10A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	53,457,781 - 54,049,735 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	53,462,979 - 53,801,966 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	54,243,884 - 54,542,326 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	53,634,410 - 54,231,358 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	53,639,079 - 53,984,940 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	53,531,754 - 53,830,179 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	53,379,457 - 53,678,753 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	54,012,303 - 54,310,827 (-)	NCBI		UU_Cfam_GSD_1.0

Pde10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	148,143,922 - 148,659,124 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	15,400,629 - 15,671,600 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	15,401,248 - 15,671,594 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE10A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	2,829,411 - 3,392,651 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	3,120,418 - 3,394,236 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	4,618,673 - 4,742,489 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE10A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	93,012,027 - 93,684,349 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	93,020,696 - 93,344,369 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	64,833,189 - 65,491,475 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pde10a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624785	13,497,495 - 13,880,345 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624785	13,208,518 - 13,885,261 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003820230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055114307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055114308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055114309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055114310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055114311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063605533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000045003 ⟹ ENSPPAP00000022196

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	168,265,707 - 168,645,231 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000045014 ⟹ ENSPPAP00000022207

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	168,265,707 - 168,596,407 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000045022 ⟹ ENSPPAP00000022215

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	168,265,707 - 168,596,407 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000045049 ⟹ ENSPPAP00000022242

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	168,265,707 - 168,478,865 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000045056 ⟹ ENSPPAP00000022248

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	168,265,707 - 168,397,022 (-)	Ensembl

RefSeq Acc Id:

XM_003820230 ⟹ XP_003820278

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,854,294 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 183,750,462 (-)	NCBI
Mhudiblu_PPA_v0	6	163,274,252 - 163,612,749 (-)	NCBI
PanPan1.1	6	168,259,978 - 168,596,401 (-)	NCBI

Sequence:

show sequence

CTTCGCCCTCGCCGCCGCGGCCGCGCTCCTCTTCGGCTCCGACATGGAAGATGGACCTTCTAAT
AATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAG
TGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGC
AGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGATGAATCGGCTCCTAAG
GAAGTCAGCAGGTACCAAGATACGAATATGCAGGGAGTTGTATATGAACTAAACAGCTATATAG
AACAACGGTTGGACACAGGAGGAGACAACCAGCTACTCCTCTATGAACTGAGCAGCATCATTAA
AATAGCCACAAAAGCCGATGGATTTGCACTGTATTTCCTTGGAGAGTGCAATAATAGCCTGTGC
ATATTCACACCACCTGGGATAAAGGAAGGAAAACCCCGCCTCATCCCTGCTGGGCCCATCACTC
AGGGCACCACCGTCTCTGCTTATGTGGCCAAGTCCAGGAAAACACTGCTAGTAGAAGACATCCT
TGGAGATGAACGATTTCCAGGAGGTACTGGACTGGAATCAGGGACTCGTATCCAGTCTGTTCTT
TGCTTACCAATTGTCACTGCAATTGGTGACTTGATTGGTATTCTCGAGCTGTATCGGCACTGGG
GCAAAGAAGCCTTCTGTCTTAGTCACCAGGAGGTTGCAACAGCAAATCTTGCCTGGGCTTCAGT
AGCAATACATCAGGTGCAGGTATGCAGAGGCCTTGCCAAACAGACAGAATTGAATGACTTCCTA
CTCGACGTATCAAAAACATATTTTGATAACATAGTTGCAATAGATTCTCTACTTGAACACATAA
TGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCACTTTTCCAGGTAGACCATAAGAA
CAAGGAGTTATATTCAGACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAG
AAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCTGGCCAAGTAGCAAGAACAGGGG
AAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACAC
AGGCTACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTG
GTGCAGATGGTCAACAAAATCAGTGGCAGTGCCTTCTCTAAAACAGATGAAAACAACTTCAAAA
TGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATTCGCCACTC
AGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCGGAAGAG
TGGCAAGGCCTCATGCAATTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACT
TTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTCTACATGGTTCATCGGTCCTG
TGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTAT
CGGCGGGTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATAC
TTCAGAACAATCACACGCTTTTCACAGACCTTGAGCGCAAAGGACTGCTGATTGCGTGTCTGTG
TCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCTCTGGCC
GCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACCGTGTCCATCCTCCAGT
TGGAAGGGCACAATATCTTCTCTACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCAT
CCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAACAGGAAGCAGTTGGAAGAG
ATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGA
TGATGACTGCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAA
TGATATATATGCAGAATTCTGGGCTGAGGGTGATGAAATGAAGAAATTGGGAATACAGCCTATT
CCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAATGCCG
TGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGC
ATGCAGGGATAATCTCAGTCAGTGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATT
TCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCACTGTTCACCCTGACTC
GCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTGGGGGGGGTGG
GGGGAACCTACACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATGAG
TCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTGAGGCATCATAGACACTGAGCAACCAGGACC
ACCCCCATGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTTTCTA
ATAGGCTAATATTGCTGAGGCCTTAAAGGAAGTGGACAAAAATTATCCAGAAGGGGTACTTTTC
CATTGTATCTTTCTAATAAGGGTTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACA
TCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACATTACTATTGTGAATGGT
GAATGTTCATGTACGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATG
TCGTTGAGGTTACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGA
ATTTAGTTAGACTAAACGTAATTCTTTAAGTTCAACCTAAAGGGCTGAGATCAATAAATTTAAC
ACTAGAAGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTGTATGTTACAATAAATCTCA
GAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAG
TTTTACTGAACCCTTTGCATAAAGAACAAAATAAAAGCACGGCATTGTAATTTTTTTAATGGAC
AAGTCTTACAGATATGAAGGGTACATTTTTCATAATGATTCCTTTATATTTTCACTTTGTGTCA
TTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATA
CCATACAGTTCTCTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTG
CCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCACGGTCGTATTTCATGAGCTTTCTGTC
CATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC
TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCT
TTTTGGTTGACCAGTATTACTATACAATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGC
ACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAATTTAAAGATTTTT
AGTGCAATGGCACGGTAACCTCCAAACCTGAGTTAGACAGAGACTCACTCAGGAAGTGACAGGC
CCATCATATCAAATAACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAA
AATGGAAAAATATGCTTCTACATATTTACTACCATAGGCGTTTTGTTCATATGAGCCTGGTTTG
TGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAGAGTTGGCTCTAC
ATAAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAG
TTGCCATCTTCCCTCCGTGGAGCTCCATTTGCTATTTTCATTATACACTATGAGGTAAAATGTA
ATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATATATATGGATGG
ATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTA
TACATATGTGTATATATGATACATACACATACACACACACGAGAGACAGAAGGAAAGAGAGGAA
GAGAGAAGCAAACATGTAGGAAAAAATATAAATCAGCCCCATTCTCCCATTCTTTAAGAACAAT
GATTTTTCTTGATGGAAAATGCATATCACTTGACAGTTGACAAGAAAGTGTCATTTTTGTGTTA
GTGTATCATATAATTGAATTTGAACAAGATACATATTTTTCTGCATACAAATTTATGAAGCTGG
AGTCTACCAAACACAGCTTTAGTCACAAAAGTTAGTTTAGTTATCTCATTTTGCTTGGAGACGG
AATTTCAGGAAGGGATATATTATTTAAGATTATTGTTTAATTACAAGAATTTTAAAAGAATGTA
TGAATTCTGTTTTTTAATATAGAAAATAATTATGGAGGTAGGAATCTCATGGCTACATTTACAT
TTTTAGGTTATTACAGAAAATTCTCTTAATTTATTATAGTCAAGTGTATTATGTAATCTCTATT
TAGAACAGTTTCCCAAAGGAATGTGATTGGATTTACTGGTTGGTTAATTTCTTGTGAAATATTA
TCATAATAGAAGCACAGCTTGAACAAAAGACTGAATTCTGATGTAAACTGTCAATATTGCTTTT
ACCATGTGTAAGATTTACTTAGTAATCACAGATTTACCTAAAATAAAAGGACCCGGGTTGCAGT
GATATTTAGTTAATGATTTGTTTTGGAAAACATGCAGTTAGGAATATTTTTGTATTTTGTCAGA
TGTTTAGGAGACAGACTTTCGGGTCATGTTTCTTGTCTTTTTCCCAGATCTTTTCTTAAAAGAA
CAGTGTGACACCAGAAGCCAAGAGATGGTTTTTACTAACAACAGCTTTGCTGAGTTCCTATTAA
GGTCATATTGTGTATTGTGCCAAATTTTCCACCCAGTATAAATTTAGTAACCTGCTATGAGCAT
ATGTAGGATATTCAATTTGCAGACACTTTTGTTGGTTATGTTGGTTTATAATAGACAAGTTTTA
TGGTCATATGCAATTATTCCATTGTCTTTTTGGACACAGTGAATATGTTTTTTAGCTAAAAATG
TCCTTGGAAACGTAAATGCCTGCCAATAACATGAAATATTGAATTCGGGCAATGTGAATTAATT
AATTAGAAAAGGGTCAAAAGAAATACAATGGATGTGGAAACTAATTCTAAAAAATAGCCCTATT
AATAGGGCAGAGACTCTGGTCCATTTCCCAGCTGTACTTCTCTCTAAGAGGTGTATGAAAAACC
CATCTTGCAAAAGAAACCAAAATATTAGACACAATCGTTCCCATTCCTGACTCTTCAATGGAAA
AGGAAGGTACAGATGTTTACAGTGGTGCCCCAGGTGACTCGTTCTCACCACAACAAAAGCAACT
AATTGGAAACTAGATGTGTTCAATAATAGATTTCCTCTTTTTTGGCATGCTTTTTAGATTTTTT
TTCATTTTGTAAAATCTCAGTTAATTTTTCTTTATTGCTATATTTGTGTATACGAGACATGTTT
GTACAGGATATAAATAGATGCATAAATCCTTAGATACCTGGGTTTTTAATAGGTTTAGGTTTGG
GTATTGTGTTTCTGGTCTTTTAACTCAAAATTAAGGTTTGAGCTTTAATAGGACTAAATTATTC
ACCTGCCTTGGCCTGTGCCTTTATTTTAAATACTGCAATTTTACTTCTTCATTCATGTATTTAT
TATTTTGCTTTTCTTGCTTAAGTATAATTGAAAATATTTGTAGGAACGCACAATTCATTTTATC
AAGTTGAATGAATAGGACCATTCTCTCCTCATCAGATTTCTGTTCTTTATTTGACTTCATTGAC
ATATACCCTGGTGACTGTAACCAGTGAACTGTTCAGAGTCAGTCTTTTCGGCAAGAACTTCAGA
GAACTGTGACATTGGTTATGATGTGATTTTGGGGGGTTTCAGGTACCTAAGCATGATTTTTAAA
ATCACTTCTCTCTTTACATATTTCGAACATATGTTTGCTTTCTACACTTCGCAGATTTTATTTA
GGATTTAATTCTTTAAAGACTATATTCATTTAGTCACTATAGTGGATCTCTTCTATTGCAAGTA
TTGATCTGATTTTTAAATTATGTAAAATGTAAATCAGCCAAGTATGTCATCCGTTATAGTTTCC
CCATGCTTTCAGCGCATGGCCATGAGATTTTTACATGTGCATAAGTATTTAGCCAATACACATT
TTGCTGACTTCTTTAACCATTTATATTGTTTAAATTAGTAATATCCAATGCAGTGCACACTTTT
TTGTCTTCTTTCCAACGGAATATTTTGGTTGTCTGTAGCGTTGGATGCATTTTCTATGATAAAA
ATAGCAAGAAAAAATTAAAAAGTGTCAATGGTGTGCTGGTTCTAAATTAAGAAGATAGAACAAA
GAGAAAGACATTAATGTTACCCAAGAAACACATTTAACATCCGAAGAAGCAATGCTGTCCTCAC
TTGATGTTTCTCTTCTCAACCCAGCAATGGAGAGCAGGGCTTGCAAAGCCGTACAGAGCCTACA
TGCTCTTTCCTGCAAGTGGGAGAAAACTAATCAATGGTACACAGGGCCAGGTGTGGCCCTGTGA
GGCAAAGGATAATGTCACCTCAGGACCAAGGCGGAAACTTACAGCTGAATCCAGGGCTTACTAA
GTAGGGAAGTCAGTTTACACATTTCAGTTTTCCTCTGATGTTTTTGAGGTACTGTGTATTTGCA
GAAGTTTAAGCAGAAGGGTTTTGTTTCTATTGTAAGTTAGGTTCTAAAAGTGTATAATCTAATA
CTCTAGCCCAACTGAAATATTATATCTTGGGCGTTACAGCCTTTGTCTTTTTCTTTAGTCACCT
TAATACCCAGTCCTATGCTGTATCTCTAATAGCCTATATAAATGACATATAGGAATATTATTTT
CCATATGATCTGTTGTATGGTGTATATGCTATGTGTTCATTTCGTGTGCAAGTTCAGAGTGTAA
TAGATTTACCCAGAGAAGGTGTTTCTATACAATGCCCCTACCTATTTGAAATTACATGCTTGCC
CAACACACTGTGAAATAGTTACCAAAATTTGTACAAATGCAGCATCTTCATTCTTTCTGAGAAG
ACAAGATGGTTTTCTTTACATGAACAAATGAACAAAAGAGATCCTAGATCCATAACGTAGCTAA
GGCATCTAAGAGTTTGCTGTTGATAATCTTGCTGACCAAAAACTACTGGAGAGTAACACAGGTT
ATATGCCATCACAAATACAATGCTCATAAAGAACTGATTTGTAGAGTCAATGAACCTGTGTCCA
GAATTTTAATAGGCTCTCTATTGGAAGGAGAAAGAATTTCAAGTTAACAGTATCTAACTTTATC
ATAGTTGATGTTAGTAAATTTTAAAAAATGATTTTATATGTATGACAAAAATCTTTGTAAAATG
CGCAAGTGCAATAATTTAAAGAGGTCTTAACTTTGCATTTATAAATTATAAATATTGTACATGT
GTGTAATTTTTTCATGTATTCATTTGCAGTCTTTGTATTTAAAAAACATTTACTGTTATGTTTG
TATAATAGAACAGTAATCATTTATTATAATCTAGGCAAGTTGTAAATAAATTCATAATTCAAAC
AGCCAGTATATATGCATATATGAGTGTTATATTGCAAAATCTTTGTTTTACTTACATGGTTAAA
GCAGCAAGAATTCTTTTGTTGATATGTAATTATACACATAAAATATATATATGTATGATACATG
AAATATATTTAGAAATGTTCATAATTTTAATGGCTATCCTTTGGTGTGAATAATTGAATACAGA
GTTTTTAAAATATC

hide sequence

RefSeq Acc Id:

XM_034963224 ⟹ XP_034819115

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,846,528 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 183,742,708 (-)	NCBI
Mhudiblu_PPA_v0	6	163,274,252 - 163,605,569 (-)	NCBI

RefSeq Acc Id:

XM_034963226 ⟹ XP_034819117

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,846,529 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 183,742,708 (-)	NCBI
Mhudiblu_PPA_v0	6	163,274,252 - 163,605,173 (-)	NCBI

RefSeq Acc Id:

XM_055114307 ⟹ XP_054970282

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 186,181,000 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 184,076,963 (-)	NCBI

RefSeq Acc Id:

XM_055114308 ⟹ XP_054970283

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 186,180,996 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 184,076,960 (-)	NCBI

RefSeq Acc Id:

XM_055114309 ⟹ XP_054970284

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,790,901 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 183,687,108 (-)	NCBI

RefSeq Acc Id:

XM_055114310 ⟹ XP_054970285

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,770,356 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 183,666,609 (-)	NCBI

RefSeq Acc Id:

XM_055114311 ⟹ XP_054970286

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,790,930 (-)	NCBI
NHGRI_mPanPan1	6	183,411,044 - 183,687,137 (-)	NCBI

RefSeq Acc Id:

XM_063605533 ⟹ XP_063461603

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	185,514,841 - 185,853,070 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003820278	(Get FASTA)	NCBI Sequence Viewer
	XP_034819115	(Get FASTA)	NCBI Sequence Viewer
	XP_034819117	(Get FASTA)	NCBI Sequence Viewer
	XP_054970282	(Get FASTA)	NCBI Sequence Viewer
	XP_054970283	(Get FASTA)	NCBI Sequence Viewer
	XP_054970284	(Get FASTA)	NCBI Sequence Viewer
	XP_054970285	(Get FASTA)	NCBI Sequence Viewer
	XP_054970286	(Get FASTA)	NCBI Sequence Viewer
	XP_063461603	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000022196.1
	ENSPPAP00000022207.1
	ENSPPAP00000022215.1
	ENSPPAP00000022242.1
	ENSPPAP00000022248.1

RefSeq Acc Id:

XP_003820278 ⟸ XM_003820230

- Peptide Label:

isoform X1

- Sequence:

show sequence

MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKS
EDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLG
ECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPGGTGLESG
TRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQ
TELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEK
EGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS
RGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYH
SICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFI
MSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQ
KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFG
NRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMK
KLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRG
EETATWISSPSVAQKAAASED

hide sequence

RefSeq Acc Id:	XP_034819115 ⟸ XM_034963224
- Peptide Label:	isoform X4
- UniProtKB:	A0A2R9AYB4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034819117 ⟸ XM_034963226
- Peptide Label:	isoform X5
- UniProtKB:	A0A2R9B223 (UniProtKB/TrEMBL), A0A2R9AYB4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000022196 ⟸ ENSPPAT00000045003

Ensembl Acc Id:

ENSPPAP00000022248 ⟸ ENSPPAT00000045056

Ensembl Acc Id:

ENSPPAP00000022207 ⟸ ENSPPAT00000045014

Ensembl Acc Id:

ENSPPAP00000022215 ⟸ ENSPPAT00000045022

Ensembl Acc Id:

ENSPPAP00000022242 ⟸ ENSPPAT00000045049

RefSeq Acc Id:	XP_054970282 ⟸ XM_055114307
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9B3Z4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054970283 ⟸ XM_055114308
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9AYB4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054970286 ⟸ XM_055114311
- Peptide Label:	isoform X6
- UniProtKB:	A0A2R9AYB4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054970284 ⟸ XM_055114309
- Peptide Label:	isoform X5
- UniProtKB:	A0A2R9AYB4 (UniProtKB/TrEMBL), A0A2R9B223 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054970285 ⟸ XM_055114310
- Peptide Label:	isoform X5
- UniProtKB:	A0A2R9AYB4 (UniProtKB/TrEMBL), A0A2R9B223 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063461603 ⟸ XM_063605533
- Peptide Label:	isoform X5
- UniProtKB:	A0A2R9AYB4 (UniProtKB/TrEMBL), A0A2R9B223 (UniProtKB/TrEMBL)

Protein Domains

PDEase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034143	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000045003.1	UniProtKB/TrEMBL
	ENSPPAT00000045014.1	UniProtKB/TrEMBL
	ENSPPAT00000045022.1	UniProtKB/TrEMBL
	ENSPPAT00000045049.1	UniProtKB/TrEMBL
	ENSPPAT00000045056.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1300.10	UniProtKB/TrEMBL
	3.30.450.40	UniProtKB/TrEMBL
InterPro	GAF	UniProtKB/TrEMBL
	GAF-like_dom_sf	UniProtKB/TrEMBL
	HD/PDEase_dom	UniProtKB/TrEMBL
	PDEase	UniProtKB/TrEMBL
	PDEase_catalytic_dom	UniProtKB/TrEMBL
	PDEase_catalytic_dom_sf	UniProtKB/TrEMBL
	PDEase_CS	UniProtKB/TrEMBL
KEGG Report	pps:100975452	UniProtKB/TrEMBL
NCBI Gene	PDE10A	ENTREZGENE
PANTHER	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE	UniProtKB/TrEMBL
Pfam	GAF	UniProtKB/TrEMBL
	PDEase_I	UniProtKB/TrEMBL
PRINTS	PDIESTERASE1	UniProtKB/TrEMBL
PROSITE	PDEASE_I_1	UniProtKB/TrEMBL
	PDEASE_I_2	UniProtKB/TrEMBL
SMART	GAF	UniProtKB/TrEMBL
	HDc	UniProtKB/TrEMBL
Superfamily-SCOP	GAF domain-like	UniProtKB/TrEMBL
	HD-domain/PDEase-like	UniProtKB/TrEMBL
UniProt	A0A2R9AYB4	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9AYU8_PANPA	UniProtKB/TrEMBL
	A0A2R9B223	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9B262_PANPA	UniProtKB/TrEMBL
	A0A2R9B3Z4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB